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Emerg Infect Dis ; 26(6): 1300-1303, 2020 06.
Article in English | MEDLINE | ID: mdl-32441626

ABSTRACT

We investigated a clinical case of variant Creutzfeldt-Jakob Disease in a person heterozygous for methionine/valine at codon 129 of the prion protein gene and identified the same strain properties in variant Creutzfeldt-Jakob disease in methionine homozygous persons and in bovine spongiform encephalopathy. These results indicate no adaptation of the agent in a different genetic background.


Subject(s)
Creutzfeldt-Jakob Syndrome , Encephalopathy, Bovine Spongiform , Prions , Animals , Cattle , Codon , Creutzfeldt-Jakob Syndrome/diagnosis , Creutzfeldt-Jakob Syndrome/genetics , Humans , Prion Proteins/genetics , Prions/genetics
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