1.
Bioorg Med Chem Lett
; 22(1): 472-5, 2012 Jan 01.
Article
in English
| MEDLINE
| ID: mdl-22119475
ABSTRACT
A number of novel fused thiophene derivatives have been prepared and identified as potent inhibitors of MEK. The SAR data of selected examples and the in vivo profiling of compound 13 h demonstrates the functional activity of this class of compounds in HT-29 PK/PD models.