Regular Gymnastics for Three Weeks Lowers Blood Pressure and Cholesterol Levels in Older Women.

Background: The goal of this study is to see how elderly gymnastics affect blood pressure, plasma glucose levels, and total cholesterol levels in women over the age of 65. Objective: The purpose of this study is to look into the effects of gymnastics on changes in blood pressure, blood sugar levels, and total cholesterol levels in the elderly.. Methods: Thirty-four female elderly women were divided into two groups: those who received gymnastics and those who did not. For three weeks, regular gymnastics exercises were performed on a weekly basis. Blood pressure, plasma glucose levels, and total cholesterol levels were measured using standard techniques and methods. Results: When compared to controls, regular gymnastics exercise can significantly lower blood pressure (p < 0.05). This decrease is also observed in total cholesterol levels (p < 0.05). Conclusions: Elderly gymnastics was found to lower blood pressure and total cholesterol levels in the elderly. As a result, elderly gymnastics could be a viable option for preventing cardiovascular disease and metabolic syndrome.

Phytochemical characteristics from Phaleria macrocarpa and its inhibitory activity on the peritoneal damage of endometriosis.

BACKGROUND: Endometriois represents a gynecological disease that still becomes an issue in community. Phaleria macrocarpa is a plant native to Indonesia that contains an antioxidant substance, which may serve as apoptotic modulator and useful for angiogenesis. OBJECTIVE: This study aims to evaluate the effects of flavonoid isolates from P. macrocarpa (PM) on the development of granulomas, apoptosis, proliferation, and angiogenesis of the disease. MATERIAL AND METHODS: Total thirty mice (Mus musculus) were categorized into six groups, including the normal group (without any treatment), EMT (endometriosis) group, and EMT group treated with PM flavonoid isolates. Identification of the active compounds of P. macrocarpa was done using LC-HRMS. Measurement of granuloma scores and vascular density was done histologically. Apoptosis and proliferation analysis was performed by immunohistochemical techniques. RESULTS: There was an increase in granulomas, proliferation, and apoptosis in the peritoneal tissues of the endometriosis model. This change can be normalized by extract of P. macrocarpa. CONCLUSION: We concluded that the flavonoid isolates from P. macrocarpa can suppress the growth of endometriosis lesions through normalization of proliferation and apoptosis. Thus, the P. macrocarpa flavonoid can be used as an alternative to inhibit the development of endometriosis.