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1.
Turk J Haematol ; 31(2): 188-91, 2014 Jun.
Article in English | MEDLINE | ID: mdl-25035679

ABSTRACT

Primary non-Hodgkin's lymphoma of the adrenal gland is rare. We report the case of a 56-year-old patient suffering from B symptoms. The CT scan showed a bilateral adrenal mass without any lymph nodes. Scan-guided biopsies led to the diagnosis of diffuse large B-cell lymphoma. The medullar biopsy eliminated a secondary lymphoma. The patient was treated by immunochemotherapy with a complete response before autologous stem cell transplantation.

2.
Hematology ; 15(1): 28-32, 2010 Feb.
Article in English | MEDLINE | ID: mdl-20132659

ABSTRACT

Severe sepsis defined as infection-induced organ dysfunction or hypoperfusion abnormalities predispose to septic shock and increased mortality in neutropenic setting. We aimed at determining predictors of severe sepsis in neutropenic patients. Between 1 October and 31 December 2007, 41 patients (21 with acute myeloid leukemia, 19 with acute lymphoid leukemia and one with autologous stem cell transplantation for a mantle cell lymphoma) with chemotherapy-induced neutropenia (<0.5 x 10(9)/l) lasting for more than 7 days were included in this study. The median age was 28 years (range: 3-58 years). All patients were on oral antibacterial (colistin and gentamicin) and anti-fungal (amphotericin B) prophylaxis. The first neutropenic febrile episode was treated with piperacillin/tazobactam and colistin IV; if the patient remains febrile at 48 h from the start of this first line of treatment, amphotericin B i.v. is added. Imipenem was introduced in the case of non-response and finally glycopeptides were introduced according to the IDSA criteria. Severe sepsis and septic shock are defined according to the criteria of the consensus conference of the ACCP/SCCM excluding the leukocyte count since all the patients were neutropenic. Ninety-four febrile episodes were observed: 27 microbiologically documented (28.7%), six clinically documented (6.3%) and 61 fever of unknown origin (65%). Microbiologically documented infections were: 13 Gram-negative organisms, 11 Gram-positive organisms and three combined (Gram+ and -). Clinically documented infections were pneumonia (two), neutropenic enterocolitis (one), sinuses infection (one) and cutaneous infection (two). Severe sepsis accounted for 22 febrile episodes. Factors associated with the occurrence of severe sepsis were: hypophosphatemia (<0.8 mmol/l; p=0.05, OR=3.9, 95% CI: 1.3-45.7), hypoproteinemia (<62 g/l; p=0.006, OR=4.1, 95% CI: 1.4-11.4) and non-adapted antibiotherapy at the onset of severe sepsis (p=0.019, OR=2.7, 95% CI: 1.02-7.39). However, heart rate/systolic blood pressure ratio <1.1 (p<0.001, OR=0.1, 95% CI: 0.03-0.31) and Creactive protein <80 mg (p=0.001, OR=0.14, 95% CI: 0.04-0.54) were not predictive.


Subject(s)
Fever of Unknown Origin/etiology , Gram-Negative Bacterial Infections/epidemiology , Gram-Positive Bacterial Infections/epidemiology , Neutropenia/complications , Sepsis/epidemiology , Adolescent , Adult , Antineoplastic Agents/adverse effects , Antineoplastic Agents/therapeutic use , Bacteremia/complications , Bacteremia/microbiology , Bicarbonates/blood , Biomarkers , Blood Proteins/analysis , Child , Child, Preschool , Drug Resistance, Multiple, Bacterial , Female , Gram-Negative Bacterial Infections/blood , Gram-Negative Bacterial Infections/etiology , Gram-Positive Bacterial Infections/blood , Gram-Positive Bacterial Infections/etiology , Hematologic Neoplasms/drug therapy , Hematologic Neoplasms/surgery , Hematopoietic Stem Cell Transplantation , Hemodynamics , Humans , Hypophosphatemia/etiology , Immunocompromised Host , Lactates/blood , Male , Middle Aged , Neutropenia/chemically induced , Postoperative Complications/blood , Postoperative Complications/epidemiology , Postoperative Complications/microbiology , Risk Factors , Sepsis/blood , Sepsis/etiology , Sepsis/microbiology , Shock, Septic/blood , Shock, Septic/epidemiology , Shock, Septic/etiology , Tunisia/epidemiology , Young Adult
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