ABSTRACT
Carotid atherosclerosis is implicated in 20-30 % of strokes. However, the annual risk of stroke in patients with asymptomatic carotid stenosis is less than 5 %. Symptomatic carotid stenosis poses a greater risk for recurrent stroke with estimates as high as 15 % per year. This paper aims to raise awareness of populations at risk for carotid stenosis, the role of carotid screening and the sensitivity and specificity of various diagnostic modalities. The results of previous trials that support current guidelines for management of symptomatic and asymptomatic carotid stenosis will also be reviewed.
Subject(s)
Carotid Stenosis/diagnosis , Carotid Stenosis/therapy , Angioplasty, Balloon , Carotid Artery Diseases/complications , Carotid Artery Diseases/therapy , Carotid Stenosis/etiology , Endarterectomy, Carotid , Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Mass Screening , Risk Assessment , Stents , Stroke/etiology , Stroke/prevention & controlABSTRACT
Psoriasis is a papulosquamous disease of multifactorial etiology. A combination of genetic and environmental agents is implicated in its pathogenesis. A variety of triggers, including infection, stress, and medications, have been recognized as precipitants of this disease. Nonsteroidal anti-inflammatory drugs, beta-blockers, lithium, synthetic antimalarials, and gold are the most common drugs implicated in precipitating psoriasis. We report a patient with psoriasis induced by initiation of losartan therapy, which resolved with discontinuation of the drug. The Naranjo adverse drug reaction probability scale score indicated that the association between losartan use and psoriasis was probable.
