Subject(s)
Databases, Chemical , Perfume/chemistry , Perfume/toxicity , Sesquiterpenes/analysis , Sesquiterpenes/toxicity , Animals , Consumer Product Safety , Drug Administration Routes , Endpoint Determination , Humans , No-Observed-Adverse-Effect Level , Perfume/administration & dosage , Risk Assessment , Sesquiterpenes/administration & dosage , Toxicity TestsSubject(s)
Camphanes/toxicity , Perfume/toxicity , Propionates/toxicity , Toxicity Tests/methods , Animals , Camphanes/chemistry , Consumer Product Safety , DNA Damage/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Endpoint Determination , No-Observed-Adverse-Effect Level , Perfume/chemistry , Propionates/chemistry , Rats , Risk AssessmentSubject(s)
Cyclohexanes/toxicity , Perfume/toxicity , Toxicity Tests/methods , Animals , Consumer Product Safety , Cyclohexanes/chemistry , DNA Damage/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Endpoint Determination , No-Observed-Adverse-Effect Level , Perfume/chemistry , Rats , Risk AssessmentSubject(s)
Aldehydes/toxicity , Benzene Derivatives/toxicity , Perfume/toxicity , Toxicity Tests/methods , Aldehydes/chemistry , Animals , Benzene Derivatives/chemistry , Consumer Product Safety , DNA Damage/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Endpoint Determination , No-Observed-Adverse-Effect Level , Perfume/chemistry , Rats , Risk AssessmentABSTRACT
: The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using ethylene dodecanedioate (CAS # 54982-83-1) as a suitable read across analog, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra along with data on the target material. The environmental endpoint was completed as described in the RIFM Framework along with data on the suitable read across analog oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2).
Subject(s)
Ethers, Cyclic/toxicity , Perfume/toxicity , Toxicity Tests/methods , Animals , Consumer Product Safety , DNA Damage/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Endpoint Determination , Ethers, Cyclic/chemistry , No-Observed-Adverse-Effect Level , Perfume/chemistry , Rats , Risk AssessmentSubject(s)
Acetates/toxicity , Norbornanes/toxicity , Perfume/toxicity , Toxicity Tests/methods , Acetates/chemistry , Animals , Consumer Product Safety , DNA Damage/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Endpoint Determination , No-Observed-Adverse-Effect Level , Norbornanes/chemistry , Perfume/chemistry , Rats , Risk AssessmentABSTRACT
The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog linalyl phenylacetate (CAS # 7143-69-3) show that this material does not have skin sensitization potential. The repeated dose toxicity endpoint was completed using linalyl cinnamate (CAS # 78-37-5) as a suitable read across analog, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8), benzoic acid (CAS # 65-85-0) and sodium benzoate (CAS # 532-32-1) as suitable read across analogs, which provided a MOE > 100. The local respiratory toxicity endpoint was completed using linalool (CAS # 78-70-6) and benzoic acid (CAS # 65-85-0) as suitable read across analogs, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework along with data from the suitable read across analog linalyl cinnamate (CAS # 78-375).
Subject(s)
Benzoates/toxicity , Monoterpenes/toxicity , Perfume/toxicity , Toxicity Tests/methods , Animals , Benzoates/chemistry , Consumer Product Safety , DNA Damage/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Endpoint Determination , Monoterpenes/chemistry , No-Observed-Adverse-Effect Level , Perfume/chemistry , Rats , Risk AssessmentABSTRACT
The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog linalool (CAS # 78-70-6) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE > 100 for the local respiratory endpoint. The repeated dose, developmental and reproductive toxicity endpoints were completed using nerolidol (isomer unspecified, CAS # 7212-44-4) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
Subject(s)
Fatty Alcohols/toxicity , Perfume/toxicity , Toxicity Tests/methods , Animals , Consumer Product Safety , DNA Damage/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Endpoint Determination , Fatty Alcohols/chemistry , No-Observed-Adverse-Effect Level , Perfume/chemistry , Rats , Risk AssessmentABSTRACT
The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog 2-ethylhexanol (CAS # 104-76-7) show that this material is not genotoxic. Data from the suitable read across analog isopropyl alcohol (CAS # 67-63-0) show that this material does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using 2-ethylhexanol (CAS # 104-76-7) and 1-heptanol, 2-propyl (CAS # 10042-59-8) as suitable read across analogs, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using 2-ethyl-hexanol (CAS # 104-76-7) and isobutyl alcohol (CAS # 78-83-1) as suitable read across analogs, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
