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Intranasal infection by SARS-CoV-2 Omicron variants can induce inflammatory brain damage in newly weaned hamsters.

Li, Can; Song, Wenchen; Chan, Jasper Fuk-Woo; Chen, Yanxia; Liu, Feifei; Ye, Zhanhong; Lam, Alvin Hiu-Chung; Cai, Jianpiao; Lee, Andrew Chak-Yiu; Wong, Bosco Ho-Yin; Chu, Hin; Lung, David Christopher; Sridhar, Siddharth; Chen, Honglin; Zhang, Anna Jin-Xia; Yuen, Kwok-Yung.

Emerg Microbes Infect ; 12(1): 2207678, 2023 Dec.

Article in English | MEDLINE | ID: mdl-37122119

ABSTRACT

SUMMARY: Intranasal infection of newly-weaned Syrian hamsters by SARS-CoV-2 Omicron variants can lead to brain inflammation and neuron degeneration with detectable low level of viral load and sparse expression of viral nucleoprotein.

Subject(s)

COVID-19 , Encephalitis , Animals , Cricetinae , SARS-CoV-2 , Mesocricetus , Brain

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