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1.
Rev Sci Instrum ; 83(10): 10D511, 2012 Oct.
Article in English | MEDLINE | ID: mdl-23130790

ABSTRACT

A new endoscope with optimised divertor view has been developed in order to survey and monitor the emission of specific impurities such as tungsten and the remaining carbon as well as beryllium in the tungsten divertor of JET after the implementation of the ITER-like wall in 2011. The endoscope is a prototype for testing an ITER relevant design concept based on reflective optics only. It may be subject to high neutron fluxes as expected in ITER. The operating wavelength range, from 390 nm to 2500 nm, allows the measurements of the emission of all expected impurities (W I, Be II, C I, C II, C III) with high optical transmittance (≥ 30% in the designed wavelength range) as well as high spatial resolution that is ≤ 2 mm at the object plane and ≤ 3 mm for the full depth of field (± 0.7 m). The new optical design includes options for in situ calibration of the endoscope transmittance during the experimental campaign, which allows the continuous tracing of possible transmittance degradation with time due to impurity deposition and erosion by fast neutral particles. In parallel to the new optical design, a new type of possibly ITER relevant shutter system based on pneumatic techniques has been developed and integrated into the endoscope head. The endoscope is equipped with four digital CCD cameras, each combined with two filter wheels for narrow band interference and neutral density filters. Additionally, two protection cameras in the λ > 0.95 µm range have been integrated in the optical design for the real time wall protection during the plasma operation of JET.

2.
Rev Sci Instrum ; 82(6): 063509, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21721693

ABSTRACT

At the TEXTOR tokamak in Jülich, Germany, a modular dispersion interferometer was installed and operated for the first time. Equipped with four lines of sight, the line-integrated density could be measured in parallel at different major radii with a resolution of better than 3 × 10(17) m(-2). This paper will describe the setup and show the first measurement results. Among others, it was possible to detect the evolution of a disruption with a time resolution of 4 µs. The movement of the runaway beam following the disruption could be resolved spatially and temporarily.

3.
Rev Sci Instrum ; 79(10): 10E708, 2008 Oct.
Article in English | MEDLINE | ID: mdl-19044526

ABSTRACT

The design and main characteristics of 14-channel dispersion interferometer for plasma profile measurement and control in TEXTOR tokamak are presented. The diagnostic is engineered on the basis of modular concept, the 10.6 microm CO(2) laser source and all optical and mechanical elements of each module are arranged in a compact housing. A set of mirrors and retroreflectors inside the TEXTOR vacuum vessel provides full coverage of the torus cross section with 12 vertical and two diagonal lines of sight, no rigid frame for vibration isolation is required. Results of testing of the single-channel prototype diagnostic and the pilot module of the multichannel dispersion interferometer are presented.

4.
Heart ; 92(1): 80-4, 2006 Jan.
Article in English | MEDLINE | ID: mdl-15883134

ABSTRACT

OBJECTIVE: To investigate the effect of reducing stent length on the rate of target lesion restenosis. DESIGN: In a prospective investigation, acute and long term results of a short stenting procedure were analysed by quantitative angiography and compared with results of a conventional stenting procedure selected according to a matched pairs analysis. PATIENTS: Short stents were implanted in 400 consecutive patients with 464 lesions and conventional stents in 430 patients. Demographic and lesion characteristics were comparable between groups. INTERVENTIONS: In short stenting, the shortest stent length to cover only segments with > 30% reduction in vessel diameter was used. In conventional stenting, full coverage of a stenotic vessel segment was intended. MAIN OUTCOME MEASURES: The mean stent lengths of the short stent group (9.8 (4) mm) and the conventional stent group (16.3 (7) mm) differed significantly (p < 0.0001); all other procedural and angiographic parameters were the same. Procedural success was similar for both groups. Control angiography after six months was conducted in 92% of patients. RESULTS: Short stenting resulted in both less restenosis (68 of 431 (15.8%)) than conventional stenting (93 of 381 (24.4%), p = 0.007) and less late lumen loss (0.6 (0.6) mm v 0.75 (0.5) mm, p = 0.0001). Residual stenosis (< 45%) in adjacent vessel segments after short stenting did not affect the restenosis rate. Only the implantation of a < or = 9 mm stent predicted the absence of restenosis in a multivariate analysis. CONCLUSION: Shortening the length of bare metal stents reduces the restenosis rate as compared with conventional stenting.


Subject(s)
Coronary Restenosis/prevention & control , Stents , Angina Pectoris/etiology , Angina Pectoris/surgery , Case-Control Studies , Coronary Angiography , Female , Follow-Up Studies , Humans , Male , Middle Aged , Myocardial Ischemia/etiology , Myocardial Ischemia/surgery , Prosthesis Design , Recurrence , Treatment Outcome
5.
Ultraschall Med ; 25(1): 25-33, 2004 Feb.
Article in German | MEDLINE | ID: mdl-14961421

ABSTRACT

Coronary flow reserve can be determined echocardiographically in the LAD in about 90 % and in the RCA in more than 80 % of patients respectively by the use of modern high-resolution ultrasound equipment. For this purpose either high frequency fundamental imaging or echo-contrast enhanced harmonic Doppler technology is used. The main advantage of the method lies in its noninvasiveness and the lack of radiation exposure. In combination with coronary morphologic findings obtained from heart catheterization, CFR is helpful in the planning of further invasive procedures for coronary artery disease and in the estimation of the prognosis of such procedures. The functional status after PTCA of LAD/RCA or mammary bypass surgery can be evaluated during follow-up monitoring. Alteration in the coronary microcirculation can also be discovered in a non-invasive way, improvement of microcirculatory disorders by adequate therapy can be assessed by serial measurements of CFR.


Subject(s)
Coronary Circulation , Echocardiography/methods , Angioplasty, Balloon, Coronary , Cardiac Catheterization , Echocardiography, Transesophageal , Humans , Internal Mammary-Coronary Artery Anastomosis
6.
Z Kardiol ; 92(2): 137-46, 2003 Feb.
Article in German | MEDLINE | ID: mdl-12596075

ABSTRACT

Coronary flow reserve (CFR) can be determined echocardiographically in the LAD in about 90% and in the RCA in more than 70% of patients, respectively, by the use of modern high-resolution ultrasound equipment. For this purpose either high frequency fundamental imaging or echo-contrast enhanced harmonic Doppler technology is used. The main advantage of the method lies in its noninvasiveness and the lack of radiation exposure. In combination with coronary morphologic findings obtained from heart catheterization, CFR is helpful in the planning of further invasive procedures for coronary artery disease and in the estimation of the prognosis of such procedures. The functional status after PTCA of LAD/RCA or mammary bypass surgery can be evaluated during follow-up monitoring. Alteration in the coronary microcirculation can also be discovered in a non-invasive manner; improvement of microcirculatory disorders by adequate therapy can be assessed by serial measurements of CFR


Subject(s)
Coronary Circulation/physiology , Coronary Disease/diagnostic imaging , Echocardiography , Image Enhancement , Angioplasty, Balloon, Coronary , Coronary Disease/physiopathology , Coronary Disease/therapy , Echocardiography, Doppler, Color , Humans , Microcirculation/diagnostic imaging , Microcirculation/physiopathology , Myocardial Revascularization , Postoperative Complications/diagnostic imaging , Reference Values
7.
Dtsch Med Wochenschr ; 128(5): 190-5, 2003 Jan 31.
Article in German | MEDLINE | ID: mdl-12557110

ABSTRACT

BACKGROUND AND AIM OF STUDY: Disturbance of the microvascular coronary circuit is common in diabetics with erectile dysfunction. We investigated effects of sildenafil on coronary flow reserve (CFR) of the left anterior descending branch. PATIENTS AND METHODS: 43 diabetics (aged 59 +/- 7 years) with erectile dysfunction and without symptoms of coronary artery disease were selected. Cardiac diagnosis, including stress ECG and echocardiography was performed in all. Because of the clinical suspicion of coronary artery disease coronary angiography was performed in 16 of them. Severe coronary artery disease was confirmed in 12 patients who were excluded from further analyses as well as 10 diabetics in whom coronary flow measurements were not possible. In the other 21 diabetics, adenosine-mediated CFR was calculated at baseline and 1 hour after ingestion of 50 mg sildenafil by transthoracic Doppler echocardiography. RESULTS: CFR at baseline was at the lower level of the normal range in 17/21 diabetics (median 245 %, range 210 - 490 %). CFR decreased insignificantly in 12/21 patients after sildenafil administration (Delta CFR -10 %, p = 0.3). Patients with a body mass index > 25 kg/m(2), and left ventricular hypertrophy had the highest reduction of CFR after sildenafil, but a drop of the CFR below 200 % was not observed in any patient. Systemic blood pressure dropped significantly from 130/80 mmHg to 120/72 mmHg (p < 0.002). CONCLUSION: Diabetics with erectile dysfunction often have a CFR in the lower range of normal. Sildenafil did not further reduce CFR. Asymptomatic, severe coronary artery disease often can be found in diabetics with erectile dysfunction. Cardiological screening for contraindications for sildenafil seems mandatory in diabetics with a high cardiovascular risk profile.


Subject(s)
Coronary Circulation/drug effects , Diabetes Mellitus/physiopathology , Erectile Dysfunction/physiopathology , Piperazines/pharmacology , Vasodilator Agents/pharmacology , Adult , Aged , Diabetes Complications , Erectile Dysfunction/complications , Erectile Dysfunction/drug therapy , Humans , Male , Middle Aged , Piperazines/therapeutic use , Purines , Sildenafil Citrate , Sulfones , Vasodilator Agents/therapeutic use
11.
Dtsch Med Wochenschr ; 125(18): 551-6, 2000 May 05.
Article in German | MEDLINE | ID: mdl-10835980

ABSTRACT

BACKGROUND AND OBJECTIVE: CFR has proven to be useful in the selection of patients undergoing invasive treatment of coronary artery disease and in estimating their prognosis. However, CFR could only be determined in everyday practice invasively during catheterization procedures. Recent development of high-resolution transthoracic color Doppler echocardiography (TTCD) allows transthoracic visualization of distal LAD and supra-apical intra-myocardial perforator branches, and non-invasive measurement of CFR. The feasibility of non-invasive assessment of coronary flow reserve (CFR) in the left anterior descending artery (LAD) using echo-enhanced high resolution TTCD was investigated. The results were compared with the degree of coronary diameter-stenosis obtained during cardiac catheterization. CFR was determined by measuring to ratio of pulsed wave Doppler time velocity integral during adenosine-induced hyperemia (140 micrograms/kg/min i.v.) to baseline value. If Doppler signal of LAD flow was insufficiently at basal condition, an echo enhancer (Levovist) was used. PATIENTS AND METHODS: 70 patients were examined by TTCD (7 MHz B-Mode, 5 MHz color Doppler, 3.5 MHz PW-Doppler) after coronary angiography had been performed. Gr I consisted of 14 patients without heart disease, Gr II of 26 patients with 40-75% isolated LAD diameter-stenosis, and Gr III of 30 patients with > 75% LAD diameter-stenosis. RESULTS: CFR could be quantified in 56/70 patients (80%), in 42/70 patients without echo enhancer, and in 14/28 patients with an echo-enhancing agent. CFR in Gr I was 3.84 +/- 0.57, in Gr II 2.31 +/- 0.20 (vs Gr I p < 0.01) and in Gr III 1.60 +/- 0.30 (vs Gr II p < 0.02). CONCLUSION: CFR of LAD can be determined in 80% of patients by the synergistic use of high resolution TTCD combined with intravenous given ultrasound echo-enhancing agent. A coronary flow reserve of less than 2.1 detected in this patient cohort significant LAD-stenosis with a sensitivity and specificity of 91% and 76%.


Subject(s)
Coronary Circulation , Coronary Disease/diagnosis , Echocardiography, Doppler, Color , Adult , Aged , Analysis of Variance , Blood Flow Velocity , Coronary Vessels/physiology , Female , Humans , Male , Middle Aged , Sensitivity and Specificity
12.
J Am Soc Echocardiogr ; 12(3): 186-95, 1999 Mar.
Article in English | MEDLINE | ID: mdl-10070182

ABSTRACT

OBJECTIVES: The feasibility of noninvasive assessment of coronary flow reserve (CFR) in the distal left anterior descending artery (LAD) with echocardiography-enhanced transthoracic pulsed wave Doppler guided by high-resolution transthoracic color Doppler (TTCD) was investigated. The results were compared with the degree of coronary diameter stenosis obtained during cardiac catheterization. BACKGROUND: Assessment of CFR has proven to be useful in the selection of patients undergoing invasive treatment of coronary artery disease and in estimating their prognosis. However, CFR could only be determined invasively in everyday practice during catheterization procedures. Recent development of high-resolution TTCD allows transthoracic visualization of distal LAD and supra-apical intramyocardial perforator branches and noninvasive measurement of CFR with pulsed wave Doppler technique. METHODS: CFR was determined by measuring the ratio of pulsed wave Doppler time velocity integral during adenosine-induced hyperemia (140 microgram/kg/min intravenously) to baseline value. If the baseline Doppler signal of LAD flow was insufficient, an echocardiography (echo) enhancer (Levovist) was used. Forty-five patients were examined by TTCD (7-MHz B-mode, 5-MHz color Doppler, and 3.5-MHz pulsed wave Doppler) after coronary angiography had been performed. Group 1 consisted of 15 patients without heart disease, group 2 of 15 patients with 50% to 85% isolated LAD diameter stenosis, and group 3 of 15 patients with >85% LAD diameter stenosis. RESULTS: Peripheral LAD coronary flow at baseline condition was assessed in 40 (88%) patients with TTCD. CFR could be quantified in 36 (80%) of the 45 patients: in 18 patients without echo enhancer, and in 18 patients with echo-enhancing agent. CFR could not be assessed in 9 (20%) patients. CFR in the various groups was as follows: group 1, 3. 13 +/- 0.57; group 2, 2.23 +/- 0.20 (vs group 1: P <.01); and group 3, 1.64 +/- 0.30 (vs group 2: P <.02). CONCLUSION: CFR in the LAD can be determined in 80% of patients with pulsed wave Doppler guided by high-resolution TTCD combined with intravenously administered echo-enhancing agent.


Subject(s)
Coronary Disease/diagnostic imaging , Coronary Vessels/diagnostic imaging , Echocardiography, Doppler , Image Enhancement , Signal Processing, Computer-Assisted , Aged , Coronary Angiography , Coronary Disease/physiopathology , Coronary Vessels/physiology , Feasibility Studies , Female , Humans , Male , Middle Aged , Observer Variation , Regional Blood Flow
13.
Dtsch Med Wochenschr ; 123(34-35): 997-1000, 1998 Aug 21.
Article in German | MEDLINE | ID: mdl-9739764

ABSTRACT

HISTORY AND CLINICAL FINDINGS: A 64-year-old obese man had for 15 years suffered from exercise-independent retrosternal pressure sensation, radiating to the neck and back. Shortly after the onset of these symptoms he had undergone coronary angiography with negative results. But at that time the resting ECG showed discrete T wave negativity in the left precordial leads. INVESTIGATIONS: At the present admission the ECG showed deeply inverted T waves in the left precordial and limb leads and a positive Sokolow-Lyon index of 4.8 mV. Left ventricular angiography demonstrated in enddiastole a circumscribed myocardial hypertrophy limited to the apex and of typical "ace of spade" shape. DIAGNOSIS, TREATMENT AND COURSE: Left-heart catheterization and angiocardiography provided the diagnosis of circumscribed apical left ventricular hypertrophy (ALVH). As the patient had only minor symptoms no treatment was given. CONCLUSION: Circumscribed ALVH can show marked dynamic development in long-term observations. If there is marked T wave negativity, even with previously normal LV angiography, circumscribed ALVH should be included in the differential diagnosis. Patients with atypical angina pectoris and increasingly suggestive ECG changes should, even if previous coronary angiography had been negative, undergo transthoracic echocardiography with a high-frequency transducer, special attention being paid to muscular changes at the LV apex.


Subject(s)
Hypertrophy, Left Ventricular/etiology , Angina Pectoris/etiology , Cardiac Catheterization , Coronary Angiography , Diagnosis, Differential , Echocardiography, Transesophageal , Electrocardiography , Humans , Hypertrophy, Left Ventricular/diagnosis , Hypertrophy, Left Ventricular/physiopathology , Male , Middle Aged , Obesity/complications , Risk Factors , Smoking Cessation
14.
Herz ; 23(8): 516-25, 1998 Dec.
Article in German | MEDLINE | ID: mdl-10023586

ABSTRACT

UNLABELLED: The feasibility of non-invasive assessment of coronary flow reserve (CFR) in the left anterior descending artery (LAD) using echo-enhanced high-resolution transthoracic color Doppler echocardiography (TTCD) was investigated. The results were compared with the degree of coronary diameter-stenosis obtained during cardiac catheterization. CFR has proven to be useful in the selection of patients undergoing invasive treatment of coronary artery disease and in estimating their prognosis. However, CFR could only be determined in everyday practice invasively during catheterization procedures. Recent development of high-resolution TTCD allows transthoracic visualization of distal LAD and supra-apical intramyocardial perforator branches, and non-invasive measurement of CFR. CFR was determined by measuring the ratio of pulsed-wave Doppler time velocity integral during adenosine-induced hyperemia (140 micrograms/kg/min i.v.) to baseline value. If Doppler signal of LAD flow was insufficiently at basal condition, an echo enhancer (Levovist) was used. 45 patients were examined by TTCD (7 MHz B-mode, 5 MHz color Doppler, 3.5 MHz PW Doppler) after coronary angiography had been performed. Group I consisted of 15 patients without heart disease, Group II of 15 patients with 40 to 70% isolated LAD diameter stenosis, and Group III of 15 patients with > 70% LAD diameter stenosis. Peripheral LAD coronary flow at baseline condition was assessed in 40 patients (88%) using TTCD. CFR could be quantified in 36/45 patients (80%), in 18 patients without echo enhancer, and in 18 patients with echo-enhancing agent. In 9/45 patients CFR could not be assessed. CFR in Group I was 3.13 +/- 0.57, in Group II 2.23 +/- 0.20 (vs Group I p < 0.01) and in Group III 1.64 +/- 0.30 (vs Group II p < 0.02). CONCLUSION: CFR of LAD can be determined in 80% of patients by the synergistic use of high-resolution TTCD combined with intravenous given ultrasound echo-enhancing agent.


Subject(s)
Coronary Circulation/physiology , Coronary Disease/diagnostic imaging , Echocardiography, Doppler, Color , Image Enhancement , Image Processing, Computer-Assisted , Adult , Aged , Blood Flow Velocity/physiology , Collateral Circulation/physiology , Coronary Angiography , Female , Humans , Male , Middle Aged , Prognosis , Sensitivity and Specificity
15.
Z Kardiol ; 86(10): 839-47, 1997 Oct.
Article in German | MEDLINE | ID: mdl-9454451

ABSTRACT

The analysis of the pulmonary venous flow Doppler pattern can assist in the determination of the severity of mitral regurgitation and, in conjunction with transmitral flow pattern, the assessment of left ventricular diastolic dysfunction. In about one third of the cases, however, transthoracic ultrasonography is not able to record an adequately analyzable pulmonary venous flow pattern. The aim of the study was to examine and compare the effect of the echo-enhancing agent Levovist on the pulsed-wave Doppler flow quality of the transthoracically (TTE) and transesophageally (TEE) recorded pulmonary venous flow. In 26 consecutive patients, a qualitative (score system) and quantitative analysis of the pulmonary venous flow pattern was obtained before and after peripheral venous injection of Levovist at concentrations of 200 mg/ml (low dose) and 400 mg/ml (high dose). The number of measurable studies for the antegrade pulmonary venous flow increased after Levovist from 85% to 96% for TTE and from 96% to 100% for TEE. The retrograde flow as seen by TTE was adequately analyzable in only 45% before and in 73% after injection of Levovist (p < 0.02). Before any contrast enhancement, the retrograde pulmonary venous flow recorded by TEE could be analyzed in 77% of the patients with the percentage increasing to 88% and 92% after administration of a low and high dose of Levovist, respectively (p < 0.05). In particular, the quality score of the retrograde flow was significantly altered by the administration of Levovist (increase from 1.8 +/- 1.0 to 2.6 +/- 1.1 (low dose Levovist), p < 0.05 and to 2.7 +/- 1.3 (high dose Levovist). p < 0.05). The pulsed-wave Doppler evaluation by TTE without Levovist underestimated the velocities of the antegrade and retrograde pulmonary venous flow After administration of Levovist, the recorded values are comparable to those obtained by TEE. An analogous pattern is encountered when quantifying the duration of the retrograde flow component. Thus, the peripheral venous injection of Levovist leads to an improved quality of the pulmonary venous flow Doppler signal recorded by TTE. Qualitatively and quantitatively the values recorded by TTE after administration of Levovist are comparable to those of the TEE technique without an echo-enhancing agent.


Subject(s)
Contrast Media , Echocardiography, Doppler , Echocardiography, Transesophageal , Image Enhancement , Mitral Valve Insufficiency/diagnostic imaging , Polysaccharides , Pulmonary Veins/diagnostic imaging , Ventricular Function, Left/physiology , Adult , Aged , Blood Flow Velocity/physiology , Dose-Response Relationship, Drug , Echocardiography, Transesophageal/instrumentation , Female , Humans , Injections, Intravenous , Male , Middle Aged , Mitral Valve Insufficiency/physiopathology , Sensitivity and Specificity
16.
J Am Soc Echocardiogr ; 10(9): 891-8, 1997.
Article in English | MEDLINE | ID: mdl-9440066

ABSTRACT

The analysis of the pulmonary venous flow Doppler pattern can assist in the determination of the severity of mitral regurgitation and, in conjunction with transmitral flow pattern, the assessment of left ventricular diastolic dysfunction. In approximately one third of the cases, however, transthoracic ultrasonography is not able to record an adequately analyzable pulmonary venous flow pattern. The aim of the study was to examine and compare the effect of the echo-enhancing agent Levovist on the pulsed-wave Doppler flow quality of the transthoracic (TTE) and transesophageal (TEE) recorded pulmonary venous flow. In 26 consecutive patients a qualitative (score system) and quantitative analysis of pulmonary venous flow pattern was obtained before and after peripheral venous injection of Levovist at concentrations of 200 mg/ml (low dose) and 400 mg/ml (high dose). The amount of measurable studies for the antegrade pulmonary venous flow increased after the injection of Levovist from 85% to 96% for TTE and from 96% to 100% for TEE. The retrograde flow as seen by TTE was adequately analyzable in only 46% before and in 73% after the injection of Levovist (p < 0.02). Before any contrast enhancement the retrograde pulmonary venous flow recorded by TEE could be analyzed in 77% of the patients, with the percentage increasing to 88% and 92% after the administration of a low and high dose of Levovist, respectively (p < 0.05). In particular, the quality score of the retrograde flow was significantly altered by the administration of Levovist (increase from 1.8 +/- 1.0 to 2.6 +/- 1.1 [low dose Levovist], p < 0.05 and to 2.7 +/- 1.3 [high dose Levovist], p < 0.05). The pulsed-wave Doppler interrogation by TTE without Levovist underestimated the velocities of the antegrade and retrograde pulmonary venous flow. After Levovist was administered, the recorded values were comparable to those obtained by TEE. An analogous pattern is encountered when quantifying the duration of the retrograde flow component. Thus the peripheral venous injection of Levovist leads to an improved quality of the pulmonary venous flow Doppler signal recorded by TTE. On qualitative and quantitative evaluation the values recorded by TTE after administration of Levovist are comparable to those of the TEE technique without an echo-enhancing agent.


Subject(s)
Contrast Media , Echocardiography, Doppler , Image Enhancement , Polysaccharides , Pulmonary Veins/diagnostic imaging , Adult , Echocardiography, Transesophageal , Female , Humans , Injections, Intravenous , Male , Microspheres , Middle Aged , Observer Variation , Polysaccharides/administration & dosage , Pulmonary Veins/physiology , Regional Blood Flow
17.
Dtsch Med Wochenschr ; 121(38): 1152, 1153-6, 1157, 1996 Sep 20.
Article in German | MEDLINE | ID: mdl-8925735

ABSTRACT

HISTORY AND CLINICAL FINDINGS: Two patients, one aged 57 the other 44 years, complained of nonspecific symptom-palpitation, left precordial pain and dyspnoea. There were no contributory findings on physical examination in both cases. INVESTIGATIONS: Both patients had hyperlipoproteinaemia, the younger one hyperuricaemia as well. The electrocardiogram showed deeply negative symmetrical T waves in the precordial leads. Transthoracic and transoesophageal echocardiography demonstrated thickening of the apical left ventricular wall. Coronary heart disease was excluded in both patients by coronary angiography. TREATMENT AND COURSE: The findings were fully explained to both patients. As they had only minor symptoms, no specific treatment was given. CONCLUSION: Isolated apical left ventricular hypertrophy should be considered as a possible cause of marked T-wave inversion in the precordial leads; this special form of hypertrophic cardiomyopathy is rarely seen in Europeans. As autosomal dominant inheritance of this condition has been described in two families, other family members should be studied by echocardiography whenever this abnormality is found.


Subject(s)
Electrocardiography , Hypertrophy, Left Ventricular/physiopathology , Adult , Chest Pain , Coronary Angiography , Diagnosis, Differential , Dyspnea/etiology , Echocardiography , Echocardiography, Transesophageal , Humans , Hyperlipoproteinemias/complications , Hyperlipoproteinemias/diet therapy , Hypertrophy, Left Ventricular/complications , Hypertrophy, Left Ventricular/diagnostic imaging , Male , Middle Aged , Risk Factors , Smoking/adverse effects
18.
Dtsch Med Wochenschr ; 121(31-32): 971-7, 1996 Aug 02.
Article in German | MEDLINE | ID: mdl-8765400

ABSTRACT

OBJECTIVE: The cause of syncope remains unclear in half of the cases, even after extensive neurological and cardiological examination. A study was, therefore, undertaken to determine the number of patients with the suspected diagnosis of vasovagal syncope that were confirmed by the tilting table test and how often it required the additional administration of isoprenaline to do so. PATIENTS AND METHODS: A tilting table test was performed on 75 patients (49 men, 26 women; mean age 41 [17-80] years) with syncopes of uncertain cause, previous examinations having failed to discover any neurological or cardiological cause. The test was done with a head-up angle of 60 degrees for 30 min. ECG and arterial blood pressure by indwelling catheter were recorded continuously. If the test was negative, isoprenaline was given intravenously at a rate of 5 micrograms/min during a five-minute period in the horizontal position, followed by 10 minutes at 60 degrees head-up position. RESULTS: Vasovagal syncope or presyncope was induced in 49 of the 75 patients during the tilting table test, a sensitivity of 65%. But 45% of the tests were positive only with the administration of isoprenaline, i.e. an increase in sensitivity to 81.5%. In 96% of the patients with a positive test there was conformity of symptoms between the induced and the spontaneously occurring syncopes. CONCLUSION: The tilting table test is a valuable means of investigating cases of syncope. More than half of the cases of syncope of uncertain cause can be correctly diagnosed classified in this way. The additional use of isoprenaline infusion greatly increases the sensitivity of the method.


Subject(s)
Adrenergic beta-Agonists , Isoproterenol , Syncope/diagnosis , Tilt-Table Test/methods , Adolescent , Adult , Aged , Aged, 80 and over , Electrocardiography/drug effects , Female , Hemodynamics/drug effects , Humans , Male , Middle Aged , Recurrence , Syncope/classification , Syncope/physiopathology , Tilt-Table Test/instrumentation , Tilt-Table Test/statistics & numerical data
19.
Z Kardiol ; 84(8): 614-5, 1995 Aug.
Article in German | MEDLINE | ID: mdl-7571767

ABSTRACT

We report the rare congenital anomaly of a singular right coronary artery in absence of the left coronary ostium. In a 31-years-old man, coronary arterial angiography demonstrated a right coronary artery which, arising from the right Sinus Valsalvae, first described the normal right coronary arterial course but in the apical region continued to follow, in reverse direction, the normal course of the left anterior descending artery. The proximal diameter of the vessel measured 5.2 mm. Thallium scintigraphy showed no ischemia of the anterior wall. The risk of developing circumscribed atherosclerosis due to anatomical reasons seems not to be increased, as no additional bifurcation nor kinking was to be found.


Subject(s)
Coronary Angiography , Coronary Vessel Anomalies/diagnostic imaging , Adult , Coronary Artery Disease/diagnostic imaging , Humans , Male , Myocardial Ischemia/diagnostic imaging , Risk Factors , Sinus of Valsalva/diagnostic imaging
20.
J Am Soc Echocardiogr ; 8(4): 527-35, 1995.
Article in English | MEDLINE | ID: mdl-7546790

ABSTRACT

A subset of patients have substantial discomfort on examination with transesophageal echocardiography with the conventional probe, whereby the dimensions of the probe play a decisive role. Miniaturized biplane transducers have recently become available (2 x 32 channels, dimensions 9.5 x 8.7 mm, and circumference approximately 30% less than the conventional echoscope) and allow ultrasound examination at 3.5, 5.0 and 7.0 MHz. A prospective study was carried out in 90 patients to compare difficulties on insertion of the probe, subjective evaluation by the patient during examination, and the two-dimensional image, as well as Doppler and color-coded Doppler quality of the miniaturized biplane versus the conventional probe. In 62 patients, intubation of the esophagus proved less difficult with the smaller instrument and more difficult in nine cases. Seventy-six patients reported that they suffered less discomfort on use of the narrow instrument. Concomitant parasympatholytic medication was needed with the smaller probe in seven cases and 17 times with the conventional probe. As anticipated, quality of the two-dimensional image attained by the miniaturized probe was lower. With transmit/receive frequency of 7.0 MHz, however, image resolution was excellent in the near field of 5 cm and nearly equivalent to that of the conventional probe (5.0 MHz). Pulsed-wave and continuous wave Doppler and color-coded Doppler information from both probes was similar in quality. Whenever examination with a conventional transesophageal transducer promises to be difficult, or when sedation is contraindicated because of a severe illness or respiratory insufficiency, transesophageal echocardiography should be considered with a smaller biplane probe at higher transmit-receive frequencies.


Subject(s)
Echocardiography, Transesophageal/instrumentation , Adolescent , Adult , Aged , Echocardiography, Doppler/instrumentation , Echocardiography, Doppler, Color/instrumentation , Echocardiography, Transesophageal/adverse effects , Female , Humans , Male , Middle Aged , Miniaturization , Prospective Studies , Transducers
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