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Nanotoxicology ; 6(7): 789-803, 2012 Nov.
Article in English | MEDLINE | ID: mdl-22023055

ABSTRACT

The potential toxic effects of copper oxide (CuO) nanoparticles (NPs) were studied on differentiated Caco-2 cell monolayers, a classical in vitro model of human small intestine epithelium. Two types of CuO NPs, with different specific surface area, different sizes as raw material but the same hydrodynamic diameter in suspension, differentially disturbed the monolayer integrity, were cytotoxic and triggered an increase of the abundance of several transcripts coding for pro-inflammatory cytokines and chemokines. Specific surface area was not a major variable explaining the increased toxicity when intestinal epithelium is exposed to rod-shaped CuO NPs, compared with spherical CuO NPs. The results suggest that release of Cu(II) cations and shape of these CuO NPs are likely to be implicated in the toxicity of these CuO NPs.


Subject(s)
Cell Survival/drug effects , Copper/toxicity , Intestinal Mucosa/drug effects , Metal Nanoparticles/toxicity , Analysis of Variance , Caco-2 Cells , Cell Differentiation , Copper/chemistry , Copper/pharmacokinetics , Humans , Hydrodynamics , Interleukin-8/metabolism , Metal Nanoparticles/chemistry , Metal Nanoparticles/ultrastructure , Models, Biological , Oxidative Stress/drug effects , Particle Size , Surface Properties
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