ABSTRACT
PURPOSE: This study aimed to investigate the effects of high-intensity interval training (HIIT) alone or in combination with hemp seed on total testosterone (TT) levels, sex hormone-binding globulin (SHBG), body composition, oxidative stress, and antioxidant capacity in sedentary young males. METHODS: Randomly, 48 young sedentary males were assigned among four groups (each comprising 12 individuals) as follows: HIIT + hemp seed (HH), HIIT + placebo (AT), hemp seed only (HS), and control. For eight weeks, exercise groups had HIIT three times per week. Hemp seed groups received 2 g of powder daily. The plasma levels of TT, SHBG, catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), and also body mass index (BMI), body fat percentage (BF%), and muscle mass percentage (MM%) were measured. The analysis was based on the intention-to-treat (ITT) and per-protocol (PP). RESULTS: Based on ITT, BMI and BF% decreased, and MM% increased significantly post-intervention in HIIT groups (p < 0.05). TT increased significantly in the HH [mean difference 0.45, 95% CI 0.1 to 0.7, p = 0.005] and AT [mean difference 0.37, 95% CI 0.1 to 0.7, p = 0.01]. The whole hemp seed components showed a significant antioxidant potential. However, none of the SOD, CAT, and MDA indices showed significant changes post-interventions (p ≥ 0.05). CONCLUSION: Finally, HIIT and hemp seed intake showed no significant effects on the antioxidant defense system. However, regular HIIT significantly increased TT levels and improved body composition in sedentary young males. TRIAL REGISTRATION: Iranian Registry of Clinical Trials (registration code: IRCT20140907019082N10).
Subject(s)
Cannabis , High-Intensity Interval Training , Male , Humans , Obesity , Antioxidants , Iran , Testosterone , Superoxide DismutaseABSTRACT
BACKGROUND: Metabolic syndrome (MetS) is presented with a cluster of cardio-metabolic risk factors with widespread prevalence. In the present case-control study, we aimed to examine the relationship between several minerals and renal function tests with the components of MetS in individuals with obesity. METHODS: This study included 127 individuals with obesity of both gender with or without MetS as the case and control, respectively. MetS was characterized based on the Adult Treatment Panel III (ATP III) criteria. Anthropometric variables and blood pressure were recorded. Mineral status including serum magnesium, copper, calcium, phosphorous, and iron were measured using standard colorimetric methods. Also, the serum lipid levels, concentrations of oxidized low-density lipoprotein (Ox-LDL), and renal function tests, including total protein, albumin, urea, creatinine, and uric acid were evaluated using commercial enzyme-linked immunosorbent assay (ELISA) kits. RESULTS: According to our results, individuals with obesity and MetS had higher levels of waist circumference (WC) and diastolic blood pressure (P < 0.05) compared to individuals with obesity and without MetS. Moreover, individuals with obesity and MetS had higher levels of serum total cholesterol (TC), triglyceride (TG), insulin, and iron (P < 0.05). In individuals with obesity and MetS, iron and albumin showed a positive relationship with LDL cholesterol and TG concentrations, respectively (P < 0.05 for all of them). Also, there was a positive association between serum magnesium and Ox- LDL in individuals with obesity with MetS. While, in individuals with obesity and without MetS, only a positive association between urea and uric acid with WC was observed (P < 0.05). CONCLUSION: Our results suggest that disturbed serum lipids in obesity-metabolic syndrome is associated with homeostatic changes in the level of minerals or proteins that are involved in their metabolism. Although, further studies are needed to better explain and clarify the underlying mechanism of observed relationships.
