Severe immediate reaction to nabumetone.

Nabumetone is a nonsteroidal antiinflammatory (NSAID) prodrug that inhibits cyclooxygenase-2. It has been recommended as a safe alternative in most patients with hypersensitivity reactions to NSAIDs. Systemic reactions caused by nabumetone are not frequent. We report 2 cases of immediate systemic reactions due to nabumetone. The first case involved a 68-year-old woman who developed immediate generalized pruritus, erythema, morbilliform eruption, swollen tongue sensation, diarrhea, and hypotension after the ingestion of a single dose of nabumetone. In the second case, a 77-year-old woman developed generalized pruritus, palm erythema, colic abdominal pain, diarrhea, dizziness, tightness of the chest, dyspnea, and hypotension immediately after oral intake of nabumetone. Both patients had previously tolerated this drug. Since these episodes, they have avoided nabumetone. Skin prick tests with nabumetone (10 and 100 mg/mL) were negative. Oral challenge tests with other NSAIDs, even of the same group as nabumetone, were negative in both patients. The mechanisms responsible for the reaction were not established.

Infección cutánea por Microsporum nanum / Skin infection due to Microsporum nanum

Microsporum nanum es un hongo zoófilo capaz de producir enfermedad en humanos y animales, aunque en humanos se han descrito muy pocos casos. Presentamos un paciente de 35 años que mostraba una lesión pruriginosa en antebrazo izquierdo que se diagnosticó de Tinea corporis y en cuyo cultivo para hongos se aisló Microsporum nanum

Microsporun namum is a zoofilic fungi capable of causing disease in humans and animals, although it has rarely been described in humans. We present a case of a 35 year old patient. He had an itchy lesion on the left forearm and was diagnosed of Tinea corporis: Microsporum nanum was isolated in the culture for fungi