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J Fr Ophtalmol ; 31(8): 786-9, 2008 Oct.
Article in French | MEDLINE | ID: mdl-19107045

ABSTRACT

INTRODUCTION: To study graft reepithelialization time after penetrating keratoplasty and the factors influencing this reepithelialization. PATIENTS AND METHODS: In this retrospective study, 48 patients underwent penetrating keratoplasty (52 eyes) by the same surgeon between 1998 and 2006. Recipient pre- and postoperative variables, donor characteristics, and surgical variables were analyzed. Postoperative slit-lamp examination after fluorescein staining and graft reepithelialization time were recorded. Statistical analysis was done using SPSS version 11.5 (p<0.05). RESULTS: The average graft reepithelialization time was 8.02 +/- 6.87 days. Complete corneal epithelial healing was obtained in 2.2%, 38.3%, and 63% of patients in 1, 3, and 7 days, respectively. There was a statistical correlation between graft reepithelialization time and trephination size, death-to-storage time, and storage time (p<0.05). DISCUSSION: Postoperative epithelial defects are common after penetrating keratoplasty. Many factors influence this graft reepithelialization such as abnormal lid and surface dysfunction, recipient corneal epithelium, and surgical technique. A better understanding of these factors will prevent postoperative epithelial defects and complications.


Subject(s)
Epithelium, Corneal/physiology , Keratoplasty, Penetrating , Wound Healing/physiology , Administration, Topical , Adrenal Cortex Hormones/administration & dosage , Adrenal Cortex Hormones/adverse effects , Aged , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/adverse effects , Female , Graft Survival , Humans , Hyaluronic Acid/administration & dosage , Hyaluronic Acid/therapeutic use , Male , Middle Aged , Organ Preservation/methods , Postoperative Period , Premedication , Retrospective Studies , Risk Factors , Time Factors , Tissue Donors/statistics & numerical data , Tissue and Organ Harvesting/statistics & numerical data
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