Quality of Life and Body Mass Index in Overweight Adult Women with Polycystic Ovary Syndrome During a Lifestyle Modification Program.

OBJECTIVE: To evaluate changes in body mass index (BMI) and health-related quality of life (HRQoL), including an acne parameter, of overweight adult women with polycystic ovary syndrome (PCOS) during a lifestyle modification program. DESIGN: Prospective longitudinal within-patient study. SETTING: Department of Reproductive Medicine of the Ghent University Hospital (Belgium). PARTICIPANTS: Thirty-three overweight (BMI ≥ 25 kg/m²) women with PCOS between age 18 and 43 years. METHODS: Participants followed a 24-week lifestyle modification program consisting of a diet, exercise, and psychological subprogram. BMI was assessed at Weeks 0, 8, 16, and 24 of the program. The HRQoL was measured at Week 0, 12, and 24 of the program using the PolyCystic Ovary Syndrome Questionnaire (PCOSQ) and a Visual Analogue Scale (VAS) to evaluate the influence of acne on HRQoL. RESULTS: During a 24-week period no significant decrease in BMI occurred (mean difference = 1.71, 95% confidence interval [CI] [-1.38, 4.81]. During that period, there was a significant positive evolution of the total PCOSQ score, F(2, 37.5) = 23.7, the emotions, F(2, 37.9) = 4.2, weight, F(2, 42.1) = 24.8, body hair, F(2, 35.6) = 3.3, and infertility problems domain scores, F(2, 43.1) = 15.64, of the PCOSQ, as well as of the acne VAS score, F(2, 29.3) = 4.2. These effects primarily occurred during the first 12 weeks. CONCLUSION: In spite of no significant changes in BMI, the HRQoL of overweight adult women with PCOS significantly improved during a 24-week lifestyle modification program.

Parental expectations of maternal and child health services.

This article reports on survey research (N = 1,418) aimed at examining whether parental expectations of maternal and child health (MCH) services are influenced by group characteristics (e.g., socioeconomic status [SES], ethnicity, at risk of poverty) and/or individual parenting context variables (e.g., received social support) in a context where these services are available to all. The findings reveal that parents have different expectations about the technical and relational expertise of MCH nurses. However, the authors found only very weak associations between family characteristics and parental expectations, suggesting that individual differences matter more than SES and other more traditional distinctions. Implications for MCH services are made.

Longitudinal follow-up of the mental health of unaccompanied refugee minors.

Despite growing numbers of unaccompanied refugee minors (UMs) in Europe, and evidence that this group is at risk of developing mental health problems, there still remain important knowledge gaps regarding the development of UMs' mental health during their trajectories in the host country and, in particular, the possible influencing role of traumatic experiences and daily stressors therein. This study therefore followed 103 UMs from the moment they arrived in Belgium until 18 months later. Traumatic experiences (SLE), mental health symptoms (HSCL-37A, RATS) and daily stressors (DSSYR) were measured at arrival in Belgium, after 6 and 18 months. UMs reported generally high scores on anxiety, depression and post-traumatic stress disorder (PTSD). Linear mixed model analysis showed no significant differences in mental health scores over time, pointing towards the possible long-term persistence of mental health problems in this population. The number of traumatic experiences and the number of daily stressors leaded to a significant higher symptom level of depression (daily stressors), anxiety and PTSD (traumatic experiences and daily stressors). European migration policies need to reduce the impact of daily stressors on UMs' mental health by ameliorating the reception and care facilities for this group. Moreover, regular mental health screenings are needed, in combination with, if needed, adapted psychosocial and therapeutic care.

Identifying students with dyslexia in higher education.

An increasing number of students with dyslexia enter higher education. As a result, there is a growing need for standardized diagnosis. Previous research has suggested that a small number of tests may suffice to reliably assess students with dyslexia, but these studies were based on post hoc discriminant analysis, which tends to overestimate the percentage of systematic variance, and were limited to the English language (and the Anglo-Saxon education system). Therefore, we repeated the research in a non-English language (Dutch) and we selected variables on the basis of a prediction analysis. The results of our study confirm that it is not necessary to administer a wide range of tests to diagnose dyslexia in (young) adults. Three tests sufficed: word reading, word spelling and phonological awareness, in line with the proposal that higher education students with dyslexia continue to have specific problems with reading and writing. We also show that a traditional postdiction analysis selects more variables of importance than the prediction analysis. However, these extra variables explain study-specific variance and do not result in more predictive power of the model.

Illicit drug use in the flemish nightlife scene between 2003 and 2009.

AIMS: Given the importance of party people as innovators and early adaptors in the diffusion of substance use, and given the lack of longitudinal scope in studies of the nightlife scene, we explored changes in illicit drug use among young people participating in the nightlife scene in Flanders. METHODS: A survey among party people selected at dance events, rock festivals and clubs was held in the summer of 2003 and repeated in 2005, 2007 and 2009. In total, 2,812 respondents filled in a questionnaire on the use of cannabis, ecstasy, cocaine, amphetamines, GHB and ketamine. RESULTS: The results of the multiple logistic regression analyses show that in the group of frequent pub visitors, the predicting probability of cannabis use increased over time, while the gap in drug use between dance music lovers and non-lovers of dance music narrowed. For cocaine use during the last year, an increase was found related to the housing situation (alone or with parents) of respondents. While the odds of using ecstasy decreased over the years, the odds of using GHB increased. CONCLUSION: We can conclude that monitoring emerging trends, which can be quickly observed in the nightlife scene, provides meaningful information for anticipating possible trends.

How is reward sensitivity related to bodyweight in children?

Previous research assumes that there are two seemingly opposing hypotheses for the relation between reward sensitivity (RS) and bodyweight: hyper-responsiveness model and Reward Deficiency Syndrome (RDS), leading to the proposition of a feed forward process of weight gain. High RS may contribute to overeating and weight-gain among normal weight individuals. Over time the excessive food-intake may evolve in a down-regulation of dopamine (RDS), resulting in overeating as a form of self-medication and the progression to obesity. This process was evidenced in adults showing a curvi-linear relationship between self-reported RS and BMI. The aim of the current study was to investigate the association between self-reported RS and BMI in children (10-15 years). The results confirm the non-linear relationship between RS and bodyweight and support the suggestion of the same feed forward process in children. These findings imply that it is crucial to reduce the intake of high palatable foods in high RS children to prevent the decrease in RS and reduce the risk for future weight gain.

Drug use and nightlife: more than just dance music.

BACKGROUND: Research over the last decade has focused almost exclusively on the association between electronic music and MDMA (3,4-Methylenedioxymethamphetamine or "ecstasy") or other stimulant drug use in clubs. Less attention has been given to other nightlife venues and music preferences, such as rock music or southern/funky music. This study aims to examine a broader spectrum of nightlife, beyond dance music. It looks at whether certain factors influence the frequency of illegal drug and alcohol use: the frequency of going to certain nightlife venues in the previous month (such as, pubs, clubs or goa parties); listening to rock music, dance music or southern and funky music; or sampling venues (such as, clubs, dance events or rock festivals). The question of how these nightlife variables influence the use of popular drugs like alcohol, MDMA, cannabis, cocaine and amphetamines is addressed. METHODS: The study sample consisted of 775 visitors of dance events, clubs and rock festivals in Belgium. Study participants answered a survey on patterns of going out, music preferences and drug use. Odds ratios were used to determine whether the odds of being an illegal substance user are higher for certain nightlife-related variables. Furthermore, five separate ordinal regression analyses were used to investigate drug use in relation to music preference, venues visited during the last month and sampling venue. RESULTS: Respondents who used illegal drugs were 2.5 times more likely to report that they prefer dance music. Goa party visitors were nearly 5 times more likely to use illegal drugs. For those who reported visiting clubs, the odds of using illegal drugs were nearly 2 times higher. Having gone to a pub in the last month was associated with both more frequent alcohol use and more frequent illegal substance use. People who reported liking rock music and attendees of rock festivals used drugs less frequently. CONCLUSIONS: It was concluded that a more extended recreational environment, beyond dance clubs, is associated with frequent drug use. This stresses the importance of targeted prevention in various recreational venues tailored to the specific needs of the setting and its visitors.

Current quality of life and its determinants among opiate-dependent individuals five years after starting methadone treatment.

PURPOSE: This study explores the current QoL of opiate-dependent individuals who started outpatient methadone treatment at least 5 years ago and assesses the influence of demographic, psychosocial, drug and health-related variables on individuals' QoL. METHODS: Participants (n = 159) were interviewed about their current QoL, psychological distress and severity of drug-related problems, using the Lancashire Quality of Life Profile, the Brief Symptom Inventory and the Addiction Severity Index. Potential determinants of QoL were assessed in a multiple linear regression analysis. RESULTS: Five years after the start of methadone treatment, opiate-dependent individuals report low QoL scores on various domains. No association was found between drug-related variables and QoL, but a significant negative impact of psychological distress was identified. Severity of psychological distress, taking medication for psychological problems and the inability to change one's living situation were associated with lower QoL. Having at least one good friend and a structured daily activity had a significant, positive impact on QoL. CONCLUSIONS: Opiate-dependent individuals' QoL is mainly determined by their psychological well-being and a number of psychosocial variables. These findings highlight the importance of a holistic approach to treatment and support in methadone maintenance treatment, which goes beyond fixing the negative physical consequences of opiate dependence.

Are numbers special? An overview of chronometric, neuroimaging, developmental and comparative studies of magnitude representation.

There is a current debate whether the human brain possesses a shared representation for various types of magnitude such as numerical quantities, physical size, or loudness. Here, we critically review evidence from chronometric, neuroimaging, developmental and comparative fields, and supplement it with a meta-analysis of the neuroimaging data. Together, based on such an integrative overview, we discuss limitations inherent in each approach, and the possibility whether shared, or distinct magnitude representation, or both representations exist.

The size of the Simon effect depends on the nature of the relevant task.

Four experiments were conducted to investigate contextual modulations of the Simon effect. The results showed that the Simon effect was quantitatively different depending on which kind of task needed to be performed. Importantly, this effect did not depend on the relative processing time of the relevant dimension, nor on a direct or indirect overlap between the relevant and irrelevant stimulus part. To account for the data, we refer to the neural overlap hypothesis, which extends the definition of dimensional overlap (Kornblum, Hasbroucq, & Osman, 1990) with similarity of processing regions as the key factor for the interaction between relevant and irrelevant information processing.

Processing of abstract ordinal knowledge in the horizontal segment of the intraparietal sulcus.

The anterior intraparietal sulcus, and more specifically its horizontal segment (hIPS), is known to play a crucial role in the cognitive representation of numerical quantity. Whether the involvement of hIPS is restricted to the processing of numerical information or generalizes to non-numerical ordinal dimensions remains an open question. Using functional magnetic resonance imaging during comparison tasks, we demonstrate that the hIPS is equally responsive to numbers and letters, indicating that hIPS is also involved in the representation and processing of non-numerical ordinal series. This extends the numerical processing function of IPS into the realm of abstract knowledge processing.

Tscope: A C library for programming cognitive experiments on the MS windows platform.

Tscope is a C/C+ + programming library designed for programming experiments that run on Windows 2000/XP. It is intended for a public of experimental psychologists with moderate programming skills, who are accustomed to writing their own experimental programs for DOS but have not made the step to Windows-based programming yet. It provides molecular functions for graphics, sound, timing, randomization, and response registration. Together with ANSI-C standard library functions and the powerful C syntax, this set of functions gives the experimenter the opportunity to program virtually any experiment one can come up with. Tscope is completely based on free software, is distributed under the GNU General Public License, and is available at expsy.ugent.be/tscope. An integrated development environment for compiling and running Tscope programs is also freely available.

Automatic response activation of implicit spatial information: Evidence from the SNARC effect.

In the present paper, we focus on how irrelevant implicit spatial information is processed. By irrelevant we mean information that is not required to fulfill the task and by implicit we mean information that is not directly available in the external stimulus. A good example of a task in which such information exists is the SNARC task [Dehaene, S., Bossini, S., & Giraux, P. (1993). The mental representation of parity and number magnitude. Journal of Experimental Psychology: General, 122, 371-396]. The SNARC effect shows that the magnitude of a number, although irrelevant to the task, activates spatial codes that may interfere with the task-related response. These spatial associations exist both for the horizontal and the vertical direction. In Experiment 1, response keys were discriminating in the vertical or the horizontal direction. It is shown that the impact of the numerical spatial codes on overt behavior, although automatic, depends on the response discrimination of the horizontal or the vertical dimension. In Experiment 2, response keys were assigned such that both the horizontal and the vertical direction of the response were discriminating. In this case, the horizontal and the vertical dimension of the irrelevant numerical spatial codes were shown to interact. In general, the results are in line with the response-discrimination account [Ansorge, U., & Wühr, P. (2004). A response-discrimination account of the Simon effect. Journal of Experimental Psychology: Human Perception and Performance, 30, 365-377].

Negative priming with numbers: no evidence for a semantic locus.

Selective attention has been studied extensively using the negative priming (NP) paradigm. An important issue regards the representational level at which NP occurs. We investigated this issue by using numbers as stimuli. Because numbers have a well-defined semantic organization, which can be clearly measured by means of the distance effect, they are very suitable for testing the assumption that NP is situated at a central semantic level. Four experiments are presented in which the numerical distance between prime distractor and probe target was manipulated. The task was magnitude comparison. Target and distractor were defined on the basis of colour. In Experiment 1, all numbers were presented in Arabic format; NP was observed only with identical prime distractor and probe target, and no distance-related NP was observed. This could not be explained by a decay of inhibition since in Experiment 2 similar results were obtained with a shortened response-to-stimulus interval. Experiment 3 showed that these observations also hold for numbers presented verbally. Nevertheless, a cross-notational experiment with Arabic prime and verbal probe (Experiment 4) revealed no NP whatsoever and excluded the possibility that the absence of distance-related negative priming was the result of a fine-tuned inhibitory mechanism operating at the semantic level. The results are considered in the light of current theories of negative priming.

Parietal representation of symbolic and nonsymbolic magnitude.

The close behavioral parallels between the processing of quantitative information conveyed by symbolic and nonsymbolic stimuli led to the hypothesis that there exists a common cerebral representation of quantity (Dehaene, Dehaene-Lambertz, & Cohen, 1998). The neural basis underlying the encoding of number magnitude has been localized to regions in and around the intraparietal sulcus (IPS) by brain-imaging studies. However, it has never been demonstrated that these same regions are also involved in the quantitative processing of nonsymbolic stimuli. Using functional brain imaging, we explicitly tested the hypothesis of a common substrate. Angles, lines, and two-digit numbers were presented pairwise, one to the left and one to the right of the fixation point. In the three comparison tasks, participants (n = 18) pressed the key on the side of the largest quantity. In the three control tasks, they indicated the side on which dimming occurred. A conjunction analysis between the three subtractions (comparison task-control task) revealed a site in left IPS that is specifically responsive when two stimuli have to be compared quantitatively, irrespective of stimulus format. The results confirm the hypothesis that quantity is represented by a common mechanism for both symbolic and nonsymbolic stimuli in IPS. In addition, the interaction between task and type of stimulus identified a region anterior to the conjunction site, not specific for quantitative processing, but reflecting general processes loaded by number processing.