1.
Parallel Synthesis of Sialyl Lewis X Mimetics on a Solid Phase: Access to a Library of Fucopeptides.
Angew Chem Int Ed Engl
; 37(12): 1707-1711, 1998 Jul 03.
Article
in English
| MEDLINE
| ID: mdl-29711524
ABSTRACT
A novel anchoring group p-(acyloxymethyl)benzylidene acetal (p-AMBA) enables the bidirectional functionalization of glycosylated amino acid derivatives and thus the rapid parallel synthesis of fucopeptides as sialyl Lewis X mimetics on a solid phase [Eq. (a), PEG-PS=poly(ethylene glycol) graft copolymer]. This led to the discovery of new mimetics against P-selectin with IC50 values in the low µM range.