ABSTRACT
It was established in experiments on rats that lead accumulation in organism caused by 1/100 DL50 lead acetate repeated injections connected with Ca2+ competition forcing out from bone tissue and taking it out from blood. It was accompanied by homeostasis maintenance physiologic mechanisms disturbance and lead toxic influence realization in liver, cordial, brain tissues, as well as immune toxic influence display on neutrophiles, periphery blood lymphocytes and on spleen lymphocytes.
Subject(s)
Homeostasis/physiology , Immune System/immunology , Lead Poisoning/blood , Lead Poisoning/immunology , Animals , Biomarkers , Calcium/blood , Lead/blood , MaleABSTRACT
Medication Berlition 300 oral, produced by "Berlin-Hemie", induces lower serum iron content, decrease in transferrin content of whole blood and serum proportionally to increased urinary iron excretion and lower serum bilirubin and normalizes serum glucose level. Berlition 300 oral, lipoic acid preparation made by "Berlin-He mie" (Menarini group), could be recommended for treatment of high serum iron content and iron overload, especially in association with diabetes mellitus.