ABSTRACT
Las disquinesias ciliares primitivas son etiologías raras de esterilidad primaria en caso del hombre (prevalencia 1/ 6000 a 1/ 40000). El síndrome de Kartagener es una entidad particular entre esta disquinesias ciliares primitivas. Se transmite según un modo autosómico recesivo. Se distingue por la asociación de un situs inverso, poliposis naso-sinusal y de una dilatación de los bronquios. Esta inmovilidad ciliar esta en el origen de numerosas infecciones broncopulmonares, sinusales y en el hombre, de infertilidad. Describiendo la observación de una pareja en la cual el hombre es portador de este síndrome, son analizados los orígenes genéticos de esta disquinesia y discutidas las diferentes opiniones observadas en la literatura
Primary ciliary dyskinesia is a rare etiology of sterility in man (prevalence betwen 1/ 6000 and 1/ 40000). Kartageners syndrome is an autosomal recessive disorder, characterized by total or parcial dysfunction of the ciliary or flagellated cells. This syndrome associates situs inversus, sinusitis, bronchiectasis and occasionally sterility in males. We report a case of inmotile cilia syndrome with male infertility and compare the data with four other couples reported in the literature. The difficulty is to select and alive sperm cell for ICSI
Subject(s)
Male , Adult , Humans , Kartagener Syndrome/complications , Infertility, Male/diagnosis , Ciliary Motility Disorders/complicationsABSTRACT
The object of this study was to evaluate the effect of different doses of a compound containing isoflavones 60 mg, primrose oil 440 mg and vitamin E 10 mg. (IOVE) on menopausal complaints. This was an open, multicentre, randomised, group comparative, efficacy and safety trial. A total of 1,080 postmenopausal women, with climacteric symptoms, were allocated into one of two treatment groups to receive one (Group 1; n = 562) or two IOVE capsules (Group 2; n = 518) per day. The Blatt - Kupperman scale and safety parameters including weight, body mass index, blood pressure and adverse effects were assessed at the first visit before initiating the treatment, and 3 - 6 months thereafter. In addition, cholesterol, high density lipoprotein (HDL), low-density lipoprotein (LDL) and triglyceride levels were measured at baseline and at the 6th month visit. Finally, at the end of follow-up, the patient's satisfaction was assessed. No differences between groups at the beginning of the study and during the follow-up were observed. A significant reduction in Blatt - Kupperman scores were observed in the two groups. In addition, the reduction of the symptoms was more intense in the first 3 months. Increasing doses of IOVE add no beneficial effects since both studied doses were equally effective in the reduction of climacteric complaints.
Subject(s)
Climacteric/drug effects , Isoflavones/administration & dosage , Oenothera biennis , Phytotherapy , Vitamin E/administration & dosage , alpha-Linolenic Acid/administration & dosage , Dietary Supplements , Drug Combinations , Female , Humans , Middle Aged , Plant Preparations/administration & dosage , Treatment OutcomeABSTRACT
A series of factors and its possible influence on the prognosis of cancer of the vulva are analyzed. In the present study 71 patients were studied. We have been able to establish that the main prognosis factor of cancer of the vulva is, beyond doubt, the presence of lymph node metastasis, since in absence of lymph node affection due to the cancer, survival was 100%, after five years, in those patients having positive lymph nodes, survival was 92.5% after the first year, 82.5% after three years and 70% after five years.
