Subject(s)
Biomedical Research/trends , Melanocytes/metabolism , Melanoma/physiopathology , Melanoma/therapy , Pathology/trends , Translational Research, Biomedical/trends , Animals , Biomedical Research/methods , Clinical Trials as Topic , Cooperative Behavior , Disease Models, Animal , Drug Discovery/trends , Humans , Immunity, Innate/genetics , Immunity, Innate/immunology , Interdisciplinary Communication , Melanocytes/pathology , Melanoma/diagnosis , Molecular Biology/methods , Molecular Biology/trends , Pathology/methods , Signal Transduction/drug effects , Signal Transduction/physiology , Translational Research, Biomedical/methodsABSTRACT
We previously suggested that "late" neonatal hypocalcemia is related to a low calcium-phosphorus ratio of current cow's milk-based formula compared with human milk. However, there are no longitudinal studies of ionized calcium and parathyroid hormone concentrations in neonates receiving formulas with varying Ca/P ratios. Sixty-nine term neonates were studied through 2 weeks of age, and formula-fed neonates were randomized at birth to receive formula with molar ratios of 0.9, 1.2, or 1.4. Serum phosphate concentrations on days 2 and 6 of age were higher, and ionized calcium levels lower on days 6 and 14, in formula-fed vs human milk-fed neonates. Serum intact parathyroid hormone level increased between days 2 and 6 in formula-fed neonates compared with a decrease in human milk-fed neonates. Serum parathyroid hormone level on day 6 correlated with phosphorus intake among formula-fed neonates. No differences were noted in serum mineral or hormone levels among formula-fed groups. We speculate that the lowering of serum ionized calcium concentrations in neonates fed a modern "humanized" cow's milk formula may be a factor in late neonatal hypocalcemia.
