Effects of exercise on the severity of isoproterenol-induced myocardial infarction.

The effect of exercise on the severity of isoproterenol-induced myocardial infarction was studied in male rats. Ninety-three rats were randomly divided into three groups. The exercise-isoproterenol (E-1) and exercise control (EC) groups exercised daily for thirty days on a treadmill at 1 mph, 2% grade while animals of the sedentary-isoproterenol (S-I) group remained sedentary. Eight animals were assigned to the sedentary control (SC) group which remained sedentary throughout the experimental period. Forty-eight hours after the final exercise period, S-I and E-I animals received a single subcutaneous injection of isoproterenol (250 mg/kg body weight). Animals of the S-I group exhibited significantly (Pp less than 0.05) greater mortality from the effects of isoproterenol than animals of the E-I group. Serum CPK activity for E-I animals was significantly (p less than 0.05) greater than for animals in the S-I and EC groups twenty hours following isoproterenol injection. No statistically significant differences were observed between the two isoproterenol treated groups for severity of the induced lesions, changes in heart weight, or heart weight to body weight ratios. The results indicated that exercise reduced the mortality associated with the effects of large dosages of isoproterenol but had little on the severity of the infarction.

A venereal disease knowledge evaluation instrument.

The purpose of this study was to develop a valid, reliable test to measure the knowledge of elementary school teachers about venereal disease. Recommended scientific test construction procedures were carefully followed. These included the development of a content outline and a table of specification; submitting potential test items to a review panel; revision of items and initial administration of the test; item analysis, revision, and a second administration; and the item analysis and revision which resulted in the Schmidt VD Knowlege Evaluator. This test consists of 45 multiple-choice items related primarily to syphilis and gonorrhea with some items related to the other venereal diseases. Test construction procedures assure face validity and the Kuder-Richardson formula estimates reliability to be 0.79. The instrument would be useful as a pre-test and/or post-test for inservice programs, workshops, and seminars for teachers, school nurses, or any similar group.