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1.
Acta Neurol Scand ; 102(5): 317-21, 2000 Nov.
Article in English | MEDLINE | ID: mdl-11083509

ABSTRACT

Forty-four patients suffering a stroke for the first time were examined within 10 h of the onset of symptoms; the tests performed on their admission to hospital, and thereafter on the third and seventh day, were 24-h Holter EKG with spectral analysis of heart rate variability, evaluation of arterial blood pressure and the levels of catecholamine in the blood and 24-h urine. The dynamic EKG on admission revealed that 31 (70.5%) out of the 44 patients already had arrhythmia. These alterations were observed in 9 (75%) out of 12 haemorrhagic patients with a significant (P < 0.05) prevalence compared to 22 (68.8%) of the 32 ischaemic ones. Arrhythmia showed up in 16 (76.2%) out of 21 cases with right hemisphere lesions and in 12 (63.2%) out of 19 cases of left hemisphere lesions; this difference was also significant (P<0.05). Arrhythmia was still present in 19 (43.2%) patients after 3 days and only in 2 (6.5%) patients after 7 days. The spectral analysis parameters on admission and after 3 days were significantly (P < 0.05) modified in patients with stroke plus arrhythmia, compared to patients with stroke alone and to control subjects, whereas no further differences were observed on the seventh day. Moreover, the percentage of patients with arterial hypertension and high levels of catecholamine greatly decreased from the third day onwards. A transient autonomic nervous system imbalance with prevalent sympathetic activity may justify this cardiovascular impairment during the hyperacute phase of stroke.


Subject(s)
Autonomic Dysreflexia/etiology , Autonomic Dysreflexia/physiopathology , Catecholamines/metabolism , Cerebral Infarction/complications , Cerebral Infarction/physiopathology , Dominance, Cerebral , Acute Disease , Aged , Arrhythmias, Cardiac/etiology , Autonomic Dysreflexia/metabolism , Case-Control Studies , Catecholamines/blood , Catecholamines/urine , Cerebral Infarction/metabolism , Electrocardiography, Ambulatory , Female , Humans , Hypertension/etiology , Incidence , Male , Middle Aged , Stroke/complications , Stroke/physiopathology , Time Factors
2.
Ital J Neurol Sci ; 20(3): 179-82, 1999 Jun.
Article in English | MEDLINE | ID: mdl-10541601

ABSTRACT

We performed Transcranial Doppler Monitoring to detect microembolic signals (MES) in 47 patients with moderate (30%-69%) carotid stenosis proven by selective angiography. We compared the occurrence of MES with the clinical characteristics of stenosis (symptomatic or asymptomatic) and the angiographic plaque features (nonulcerated, deep ulceration, superficial ulceration, ulceration with flap, or ulceration without flap). For these cases there was no indication for endarterectomy, nevertheless we thought it would be useful to identify risk subgroups that might benefit from surgical treatment. MES were detected in 17.9% of the stenoses with a prevalence (p <. 01) in symptomatic cases (25%) compared to asymptomatic cases (14. 3%). There was a significant correlation of MES with plaque ulceration (p <.01) and particularly with ulceration without flap (p <.01). No difference between deep and superficial ulceration was observed. The availability of prospective data on this topic might be useful to select subgroups of patients with moderate carotid stenosis at risk for embolism.


Subject(s)
Carotid Arteries/diagnostic imaging , Carotid Stenosis/complications , Carotid Stenosis/diagnostic imaging , Intracranial Embolism/diagnostic imaging , Intracranial Embolism/etiology , Ultrasonography, Doppler, Transcranial , Aged , Female , Humans , Male , Middle Aged
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