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Clin Vaccine Immunol ; 17(10): 1552-9, 2010 Oct.
Article in English | MEDLINE | ID: mdl-20702657

ABSTRACT

Erythrocyte binding antigen region II (EBA-175) is a conserved antigen of Plasmodium falciparum that is involved in binding of the parasite to the host's erythrocytes. We evaluated the safety and immunogenicity of a recombinant EBA-175 vaccine with aluminum phosphate adjuvant in healthy young adults living in the United States. Eighteen subjects/group received ascending doses (5, 20, 80, or 160 µg) of the vaccine at 0, 1, and 6 months; 8 subjects received placebo. Most of the injection site and systemic reactions were mild to moderate in intensity. After 2 or 3 doses of the vaccine at any concentration, antibody levels measured by enzyme-linked immunosorbent assay were significantly higher than those for the placebo group. Sera from subjects who received 3 doses of the vaccine at any concentration inhibited the growth of erythrocyte-stage P. falciparum at low levels compared to sera from placebo recipients or preimmune sera. In conclusion, the EBA-175 vaccine with adjuvant was safe and immunogenic in malaria-naïve subjects.


Subject(s)
Antigens, Protozoan/adverse effects , Antigens, Protozoan/immunology , Malaria Vaccines/adverse effects , Malaria Vaccines/immunology , Malaria, Falciparum/prevention & control , Protozoan Proteins/adverse effects , Protozoan Proteins/immunology , Adjuvants, Immunologic/administration & dosage , Adolescent , Adult , Aluminum Compounds/administration & dosage , Antibodies, Protozoan/blood , Antigens, Protozoan/administration & dosage , Enzyme-Linked Immunosorbent Assay , Female , Human Experimentation , Humans , Immunization, Secondary/methods , Malaria Vaccines/administration & dosage , Male , Phosphates/administration & dosage , Placebos/administration & dosage , Plasmodium falciparum/growth & development , Plasmodium falciparum/immunology , Protozoan Proteins/administration & dosage , United States , Vaccination/methods , Vaccines, Synthetic/administration & dosage , Vaccines, Synthetic/adverse effects , Vaccines, Synthetic/immunology , Young Adult
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