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Angew Chem Int Ed Engl
; 55(44): 13813-13817, 2016 10 24.
Article
in English
| MEDLINE
| ID: mdl-27714921
ABSTRACT
An approach to the intramolecular Diels-Alder reaction has led to a cascade synthesis of complex carbocycles composed of three fused rings and up to five stereocenters with complete stereocontrol. Computational analysis reveals that the reaction proceeds by a Michael/Michael/cyclopropanation/epimerization cascade in which size and coordination of the counterion is key.