ABSTRACT
The authors draw attention to a serious drug response to the derivative of the alkaloid ajmaline prajmalium (Neo-Gilurytmal, Giulini-GFR) which causes impairment of liver functions of various grades as a result of intrahepatic cholestasis. They draw attention to the necessity of a careful pharmacological case-history, evaluation of the premorbid stage, in particular former liver disease or contemporary administration of drugs which burden liver function (hormonal contraceptives, non-steroid antirheumatic drugs). It is essential to follow-up liver functions by laboratory tests already at the onset of treatment with Neo-Gilurytmal.
Subject(s)
Chemical and Drug Induced Liver Injury/etiology , Cholestasis, Intrahepatic/etiology , Prajmaline/adverse effects , Acute Disease , Aged , Humans , MaleABSTRACT
Changes of pharmacokinetics and acetylation of sulfadimidine (SDM) were studied in endotoxin pretreated rabbits. With increasing doses of endotoxin the levels of intravenously administered SDM were lower. The acetylation rate was reduced in urine of rabbits after medium endotoxin doses.
Subject(s)
Endotoxins/pharmacology , Sulfamethazine/metabolism , Acetylation , Animals , Female , Kinetics , Male , Rabbits , Sulfamethazine/bloodABSTRACT
The zinc sulphate turbidity test was used to establish the total immunoglobulin levels of calves from birth to 4 months of age. Colostral immunity fell rapidly and the lowest levels were found in the third and fourth week of life. During the fifth week there was a significant increase. 25% of animals were hypogammaglobulinaemic in the first week of life. This ratio increased to 50% in the third week of life. At the age of two months the lowest immunoglobulin levels almost vanished. These findings are discussed as basic information for the appropriate management of calf agglomerations. Animals should be agglomerated only after the first months of life. When this is not possible, the pens for large agglomerations should have individual housing for the newly admitted calves. The importance of appropriate epizootological measures to reduce infections are pointed out.
