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Bioorg Med Chem Lett
; 17(6): 1746-9, 2007 Mar 15.
Article
in English
| MEDLINE
| ID: mdl-17234409
ABSTRACT
A series of 4-arylimidazole carbamates was synthesized and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to the identification of compound 10, a potent Na+ channel blocker which was efficacious in pain models in vivo.