[Effect of alcoholic hyperlipoproteinemias on the deformability and viscosity of erythrocytes]. / Einfluss alkoholtoxischer Hyperlipoproteinämien auf die Verformbarkeit und Viskosität der Erythrozyten.

This pilot study set out to evaluate the influence of the metabolic disorder due to acute alcohol toxicity on red blood cell (RBC) deformability. RBC deformability was measured optoelectronically by microcomputer-assisted polymicroviscometry (filtrometry). Chronic alcoholic patients (n = 12) with transient haemolytic anaemia, jaundice and hyperlipoproteinaemia were studied during the acute and the remittent phase of alcoholic disease. RBC obtained from patients in the acute phase revealed a markedly impaired deformability as compared with RBC suspensions studied when the alcoholic symptoms had subsided. The study lends further support to the hypothesis that predominantly during acute alcohol toxicity patients experience a marked impairment of the adhesive and rheological properties of RBC, which may finally impair the peripheral microcirculation of the whole blood.

[Pathologic fluidity, glycohemoglobin and erythrocyte metabolism disorder in Fontaine II diabetic macroangiopathy]. / Pathologische Fluidität, Glykohämoglobin und Stoffwechselstörung der Erythrozyten bei diabetischer Makroangiopathie Fontaine II.

This pilot study set out to evaluate the influence of metabolic disorders due to diabetes mellitus on red blood cell (RBC) substrates, deformability and glycohaemoglobin (HbA1) levels. RBC deformability was measured optoelectronically by microcomputer-assisted polymicroviscometry (filtrometry) following separation of RBC into old (dense) and young (buoyant) fractions by means of density-layer centrifugation. 20 adult patients with type II diabetes mellitus associated with Fontaine II macroangiopathy underwent RBC investigations before and after diabetic therapy. Those RBC fractions containing older cells exhibited impaired metabolism, increased HbA1 levels and markedly altered deformability which significantly differed from values obtained from young RBC fractions. However, old RBC fractions only of patients treated for diabetes persistently displayed a slight increase in HbA1 levels associated with a still altered deformability, in contrast to the young RBC fractions which showed normal values again after diabetic treatment. The preliminary results suggest an adaptive alteration of RBC metabolism and function in diabetes, predominantly existing in old RBC, which still persists only in old RBC fractions after diabetic therapy. Thus, a prolonged pathologic effect of older RBC on the peripheral microcirculation may occur in diabetes, resulting in a further persistent maintenance of diabetic vascular disease.

Biorheological and metabolic dysfunctions of density-fractionated erythrocytes in diabetics with peripheral vascular disease.

Preliminary communications are presented about a serial study of biorheological and metabolic dysfunctions of density-fractionated erythrocytes (RBC) in diabetics with vaso-occlusive disorders. The study aimed at evaluating the influence of metabolic disorder due to diabetes mellitus on RBC substrates, deformability and glycohaemoglobin (HbA1) levels. The peak HbA1 level served to confirm the duration of serum metabolic disorder due to diabetic crisis. The rheological and metabolic changes of RBC were compared with serial estimations repeated on the same patients when asymptomatic concerning diabetes after insulin therapy. RBC deformability was measured optoelectronically by microcomputer-assisted polymicroviscometry (filtrometry) following separation of RBC into old (dense) and young (buoyant) fractions by means of density-layer centrifugation. 15 adult patients with diabetes mellitus typ II associated with macroangiopathy Fontaine II underwent RBC investigations before and after diabetic therapy. Those RBC fractions containing older cells disclosed an impaired metabolism, increased HbA1 levels and markedly altered deformability which significantly differed from values obtained from young RBC. But after insulin-therapy old RBC fractions only revealed persistently an increase of HbA1 levels and metabolic disorder associated with a still altered deformability, in contrast to young RBC which in again showed normal values. The preliminary results suggest an adaptable alteration of RBC metabolism and function in diabetes, predominantly existing in old RBC, but after insulin-therapy still persisting only in old (dense) fractions. Thus, a prolonged pathologic effect of older RBC occurred in diabetes probably resulting in a further persistent maintenance of diabetic vascular disease.(ABSTRACT TRUNCATED AT 250 WORDS)

[The effect of Tropaacidester Sch 1000 on respiratory resistance (author's transl)]. / Therapie der obstruktiven Atemwegerkrankung mit einem Atropinderivat (Sch 1000)

The effect of Tropaacidester Sch 1000 on respiratory resistance, intrathoracical volume, peripheral blood pressure, and heart frequency over a period of 24 hours were examined in ten patients suffering from obstructive respiratory diseases. Compared with placebo 2 puffs of Sch 1000 administered 6 times significantly decreased respiratory resistance. The bronchodilatatory effects of Sch 1000 and Orciprenalin seemed to be almost identical. Side effects after application of Sch 1000 have not been observed.