ABSTRACT
We studied specific antitumor activity of a liposomal drug based on tetra-3-phenylthiophthalocyanine aluminum hydroxide (lipophthalocyan) intended for photodynamic therapy. The optimal dose and protocol for photodynamic therapy with lipophthalocyan were chosen in experiments on mice: single intravenous dose of 6 mg/kg with a 5-h interval between administration and laser exposure and irradiation energy density of 400 J/cm2. A wide spectrum antitumor activity of lipophthalocyan was demonstrated in vivo for various transplantable mouse tumors (Lewis lung epidermoid carcinoma, S37 sarcoma, and colon adenocarcinoma AKATOL). The results show the possibility of using lipophthalocyan for photodynamic therapy of tumors of surface localization (skin and mucosa tumors).
Subject(s)
Lasers , Liposomes/chemistry , Photochemotherapy/methods , Photosensitizing Agents/therapeutic use , Animals , Carcinoma, Lewis Lung/therapy , Colonic Neoplasms/therapy , Female , Male , Mice , Mice, Inbred BALB C , Sarcoma/therapyABSTRACT
Xymedon (1-(ß-oxyethyl)-4,6-dimethyl-1,2-dihydro-2-oxopyrimidine), a regeneratory and wound-healing drug, exhibited hepatoprotective activity in laboratory animals with experimental toxic hepatitis. Oral drug reduced the severity of toxic involvement of the liver induced by CCl4 and reduced animal mortality. Xymedon promoted recovery of the blood biochemical parameters characterizing the liver status.
Subject(s)
Chemical and Drug Induced Liver Injury/drug therapy , Liver/drug effects , Protective Agents/pharmacology , Pyrimidines/pharmacology , Alanine Transaminase/metabolism , Animals , Animals, Outbred Strains , Aspartate Aminotransferases/metabolism , Blood Glucose/metabolism , Body Weight/drug effects , Carbon Tetrachloride , Chemical and Drug Induced Liver Injury/metabolism , Chemical and Drug Induced Liver Injury/pathology , Liver/metabolism , Liver/pathology , Mice , RatsABSTRACT
A pronounced antianemic effect of water-soluble Na,Ca,Fe-polygalacturonate is demonstrated. The drug in solution is more effective than in the solid form; it promotes absorption of nutrient calcium and iron. During this treatment, consumed calcium does not impair iron absorption.
Subject(s)
Anemia/drug therapy , Calcium/metabolism , Iron/metabolism , Pectins/chemistry , Pectins/therapeutic use , Sodium/metabolism , Water/chemistry , Animals , Erythrocyte Count , Female , Hemoglobins/metabolism , Rats , SolubilityABSTRACT
We studied the effects of peptides from Amaranthus cruentus L., Rauwolfia serpentina Benth., and citrus plants on contractile activity of the uterine myometrium in rats. Pectin substances inhibited spontaneous contractile activity of uterine muscles and abolished the stimulatory effect of oxytocin. Pectins had a synergistic effect with epinephrine and acetylcholine.
