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1.
J Org Chem ; 2024 Jul 03.
Article in English | MEDLINE | ID: mdl-38959385

ABSTRACT

A wide range of indolizines with allenes proceeded smoothly under mechanochemical-induced conditions via [3 + 2] annulation process, affording various substituted pyrrolo[2,1,5-cd]indolizines with good yield. The reaction efficiency was greatly improved by using a piezoelectric material as the charge transfer catalyst. The photophysical properties of the resulting pyrrolo[2,1,5-cd]indolizine was characterized.

2.
Front Pharmacol ; 14: 1308965, 2023.
Article in English | MEDLINE | ID: mdl-38149053

ABSTRACT

Psoriasis (PSO) is a common skin disease affecting approximately 1%-3% of the population, and the incidence rate is increasing yearly. PSO is associated with a dramatically increased risk of cardiovascular disease, the most common of which is atherosclerosis (AS). In the past, inflammation was considered to be the triggering factor of the two comorbidities, but in recent years, studies have found that lipid metabolism disorders increase the probability of atherosclerosis in patients with psoriasis. In this review, we discuss epidemiological studies, clinical treatment methods, risk factors, and lipid metabolism of psoriasis and atherosclerosis comorbidities.

3.
Chem Commun (Camb) ; 59(4): 458-461, 2023 Jan 05.
Article in English | MEDLINE | ID: mdl-36519391

ABSTRACT

A simple and efficient visible-light-induced approach for the formation of stable S-S-N bonds has been developed. Through these photocatalytic reactions, a series of N-disulfanyl indoles, pyrroles and carbazoles were afforded with good to excellent yields. Moreover, the gram-scale experiment has confirmed the practicability of this approach.


Subject(s)
Carbazoles , Indoles , Indoles/chemistry , Carbazoles/chemistry , Pyrroles/chemistry , Catalysis
4.
Org Lett ; 24(39): 7222-7226, 2022 Oct 07.
Article in English | MEDLINE | ID: mdl-36169201

ABSTRACT

Under mechanochemically induced conditions, a wide range of diarylphosphine oxides or H-phosphonates react with trisulfide dioxides to afford various thiophosphate derivatives in good yields. Selective S-S bond cleavage of trisulfide dioxides determined by connecting groups is proposed as the key step in the construction of P(O)-S or P(O)-S-S bonds, which is supported by calculations.

5.
J Org Chem ; 87(5): 3265-3275, 2022 Mar 04.
Article in English | MEDLINE | ID: mdl-35080180

ABSTRACT

A wide range of indolizines with allenes proceeded smoothly under mechanochemically induced conditions via a [3+2] annulation process, affording various substituted pyrrolo[2,1,5-cd]indolizines in good yields. The reaction efficiency was greatly improved by using piezoelectric material as the charge transfer catalyst. The photophysical properties of the resulting pyrrolo[2,1,5-cd]indolizine were characterized.

6.
Org Lett ; 23(18): 7171-7176, 2021 Sep 17.
Article in English | MEDLINE | ID: mdl-34459619

ABSTRACT

A simple and efficient mechanochemical-induced approach for the synthesis of 1,2-diketoindolizine derivatives has been developed. BaTiO3 was used as the piezoelectric material in this transformation. This method features no usage of solvent, simple experimental operation, scalable potential, and high conversion efficiency, which make it attractive and practical.

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