Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 5 de 5
Filter
Add more filters










Database
Language
Publication year range
1.
J Comput Assist Tomogr ; 47(6): 882-889, 2023.
Article in English | MEDLINE | ID: mdl-37948362

ABSTRACT

ABSTRACT: The purpose of this article is to provide a comprehensive review of the imaging findings along with histopathologic correlation of mature (benign) teratomas and malignant ovarian teratomas, which include both immature teratomas and malignant degeneration of mature teratomas. The radiologist's ability to provide an accurate diagnosis plays an essential role in guiding the interdisciplinary care of patients with malignant teratomas and improving their outcomes.


Subject(s)
Ovarian Neoplasms , Teratoma , Female , Humans , Multimodal Imaging , Teratoma/diagnostic imaging , Teratoma/pathology , Ovarian Neoplasms/diagnostic imaging
2.
J Magn Reson Imaging ; 58(2): 342-359, 2023 08.
Article in English | MEDLINE | ID: mdl-37052601

ABSTRACT

Solid renal masses (SRMs) are increasingly detected and encompass both benign and malignant masses, with renal cell carcinoma (RCC) being the most common malignant SRM. Most patients with SRMs will undergo management without a priori pathologic confirmation. There is an unmet need to noninvasively diagnose and characterize RCCs, as significant variability in clinical behavior is observed and a wide range of differing management options exist. Cross-sectional imaging modalities, including magnetic resonance imaging (MRI), are increasingly used for SRM characterization. Multiparametric (mp) MRI techniques can provide insight into tumor biology by probing different physiologic/pathophysiologic processes noninvasively. These include sequences that probe tissue microstructure, including intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and T1 relaxometry; oxygen metabolism (blood oxygen level dependent [BOLD-MRI]); as well as vascular flow and perfusion (dynamic contrast-enhanced MRI [DCE-MRI] and arterial spin labeling [ASL]). In this review, we will discuss each mpMRI method in terms of its principles, roles, and discuss the results of human studies for SRM assessment. Future validation of these methods may help to enable a personalized management approach for patients with SRM in the emerging era of precision medicine. EVIDENCE LEVEL: 5. TECHNICAL EFFICACY: 2.


Subject(s)
Carcinoma, Renal Cell , Kidney Neoplasms , Multiparametric Magnetic Resonance Imaging , Humans , Contrast Media , Magnetic Resonance Imaging/methods , Diffusion Magnetic Resonance Imaging/methods , Carcinoma, Renal Cell/diagnostic imaging , Kidney Neoplasms/diagnostic imaging , Motion
3.
Radiol Clin North Am ; 60(5): 775-794, 2022 Sep.
Article in English | MEDLINE | ID: mdl-35989044

ABSTRACT

Atypical liver malignancies can either be uncommon presentations of commonly encountered liver malignancies or rare tumors infrequently seen in clinical practice and often pose a challenge in diagnostic imaging interpretation. These lesions tend to be highly variable in their imaging appearance and are less well discussed in the literature. Commonly, an inter-disciplinary approach incorporating clinical information, imaging data, and histopathology is needed to reach an accurate diagnosis. The diagnostic radiologist's knowledge of such liver malignancies can aid the clinical team in reaching the correct diagnosis and enabling appropriate management. In this article, we review certain technical considerations and focus on the unusual appearances of common primary and secondary malignant liver lesions, uncommon malignant liver lesions, with emphasis on computed tomography (CT) and magnetic resonance imaging (MRI).


Subject(s)
Carcinoma, Hepatocellular , Liver Neoplasms , Carcinoma, Hepatocellular/pathology , Humans , Liver , Liver Neoplasms/diagnostic imaging , Liver Neoplasms/pathology , Magnetic Resonance Imaging/methods , Tomography, X-Ray Computed/methods
4.
ACG Case Rep J ; 6(3): 1-3, 2019 Mar.
Article in English | MEDLINE | ID: mdl-31620489

ABSTRACT

Wilson disease is an autosomal recessive disorder of abnormal copper metabolism that is prevalent in the younger population, rarely presenting in patients older than 40 years. Clinical presentation may be variable, and diagnosis is often aided by clinical and biochemical tests. We report the case of a 72-year-old woman who presented with acute liver failure initially of unclear etiology. Our patient was initially managed for presumed drug-induced liver injury but ultimately diagnosed with Wilson disease on the basis of clinical presentation, laboratory testing, liver biopsy, quantitative hepatic copper, and abnormal genetic testing.

5.
EBioMedicine ; 2(11): 1705-17, 2015 Nov.
Article in English | MEDLINE | ID: mdl-26870796

ABSTRACT

Transferrin receptor (Tfr1) is ubiquitously expressed, but its roles in non-hematopoietic cells are incompletely understood. We used a tissue-specific conditional knockout strategy to ask whether skeletal muscle required Tfr1 for iron uptake. We found that iron assimilation via Tfr1 was critical for skeletal muscle metabolism, and that iron deficiency in muscle led to dramatic changes, not only in muscle, but also in adipose tissue and liver. Inactivation of Tfr1 incapacitated normal energy production in muscle, leading to growth arrest and a muted attempt to switch to fatty acid ß oxidation, using up fat stores. Starvation signals stimulated gluconeogenesis in the liver, but amino acid substrates became limiting and hypoglycemia ensued. Surprisingly, the liver was also iron deficient, and production of the iron regulatory hormone hepcidin was depressed. Our observations reveal a complex interaction between iron homeostasis and metabolism that has implications for metabolic and iron disorders.


Subject(s)
Muscles/metabolism , Receptors, Transferrin/deficiency , Animals , Cluster Analysis , Gene Expression Regulation , Genes, Lethal , Iron Deficiencies , Iron Metabolism Disorders/genetics , Iron Metabolism Disorders/metabolism , Iron Metabolism Disorders/pathology , Liver/metabolism , Metabolome , Metabolomics/methods , Mice , Mice, Knockout , Mice, Transgenic , Muscle, Skeletal/metabolism , Muscle, Skeletal/pathology , Muscles/pathology , Oxidative Phosphorylation , Phenotype , Receptors, Transferrin/genetics
SELECTION OF CITATIONS
SEARCH DETAIL
...