[Renoprotective effect of monopril in patients with diabetes mellitus in the preclinical stage of diabetic nephropathy]. / Renoprotektornyi efekt monoprylu u khvorykh na tsukrovyi diabet v doklinichnii stadiï diabetychnoï nefropatiï.

As many as 15 patients with insulin-dependent diabetes mellitus received monopril in a dose of 5 mg daily. Studied in the patients was the drug effect on the functional renal reserve and glomerular filtration rate. Determination of the functional renal reserve has been shown to be a criterion for an early diagnosis of the preclinical stage of diabetic nephropathy. Administration of monopril in exhausted functional renal reserve permits preventing development of proteinuria or allows a lapse of time for it to develop.

[Therapeutic efficacy of lacidipine in patients with chronic glomerulonephritis and diabetic nephropathy]. / Efektyvnist' latsydypinu v likuvanni khvorykh na khronichnyi hlomerulonefryt ta diabetychnu nefropatiiu.

A total of 30 patients with diabetic nephropathy were examined together with 30 patients presenting with chronic glomerulonephritis at different stages of the condition. An unquestionable positive effect has been demonstrated of lacidipine on the arterial pressure, glomerular filtration rate, proteinuria, diuresis, excretion of nitrogenous metabolities in patients with the above pathology presenting with the normal or impaired renal function. A prognostic criterion has been developed for efficiency of treatment with lacidipine making use of the corinfar test.

[Adipose tissue as an endocrine organ: role in pathogenesis of ischemic heart disease and insulin independent diabetes mellitus]. / Zhyrova tkanyna iak endokrynnyi orhan: rol' v patohenezi ishemichnoï khvoroby sertsia ta insulinnezalezhnoho tsukrovoho diabety.

Obesity is a risk factor for cardiovascular morbidity and mortality. The present review of the modern literature is devoted to the problem of regarding the adipose tissue as not only a repository of energy supplies but an active endocrine organ as well whose activity exerts a definite effect on the function of many bodily systems. Specific emphasis is directed toward aspects of the function of certain secretory proteins involved in the process of the arterial pressure regulation and/or organs injuring.

[Mechanisms of glomerular autoimmunity and a strategy for immunomodulation in glomerular nephritis]. / Mekhanizmy samozakhystu nyrkovoho klubochka ta ïkh moduliatsiia pry hlomerylonefryti.

The article is a review of the published foreign literature concerning mechanisms of self-defence of the renal glomerulus and ways for drug correction thereof. The glomerulus self-defence intra- and extracell factors are described in detail. Novel drugs having been approbated in the experiment and in clinical settings intended to slow down the rate of progression of affections of the kidneys are mentioned together with ways for prevention thereof.

[Pro- and antiatherogenic mechanisms in chronic kidney failure]. / Pro- ta antyaterohenni mekhanizmy pry khronichnii nyrkovii nedostatnosti.

Atherosclerosis is a very common complication and frequently recordable cause of death in patients with chronic renal insufficiency (ChRI). The authors focus on current notions about causes of rapidly advancing atherosclerosis in patients presenting with manifest and terminal ChRI, who were exposed to a conservative treatment, programme hemodialysis or prolonged peritoneal dialysis. Treated in the article at length are proatherogenic (generally known, common in ChRI only) and antiatherogenic mechanisms. A worthwhile line of investigations is suggested to be designed to study ChRI pathogenesis and devise relevant preventive and curative measures.

[The pathogenetic and clinical significance of disorders in hemostatic homeostasis in diabetics]. / Patohenetychne ta klinichne znachennia porushen' hemostatychnoho homeostazu u khvorykh na tsukrovyi diabet.

DM patients who do not present with clinical manifestations of nephropathy exhibited significant reduction of urine fibrinolytic activity which is regarded as suggesting a preclinical stage of renal lesion in DM as well as hyperaggregation of platelets, enhanced activity of coagulative link of hemostasis and changes of different directions in the system of fibrinolysis. Among coagulologic methods, of most informative value is the turbidimetric method. In DM and low tolerability to glucosa, there is an increased incidence of gastroduodenal abnormalities, ulcer disease included, which fact warrants a gastroenterologic evaluation to be done in this patient population prior to prescribing anticoagulants.

[The potentials of heparin monotherapy in patients with hemorrhagic vasculitis and kidney involvement]. / Mozhlyvosti monoterapiï heparynom khvorykh na hemorahichnyi vaskulit z urazhenniam nyrok.

A retrospective analysis was done of case histories and outpatient case records of 25 patients with hemorrhagic vasculitis presenting with renal lesion, and 12 patients with hemorrhagic vasculitis without kidney damage. Heparin therapy was instituted as subcutaneous injections 4 times daily, 450-500 units/kg/24 h. A positive effect of heparin therapy correlated with the early start of the treatment and presence of the urinary syndrome. A possibility is shown of forecasting of the heparin therapy efficacy in the above patient populations in respect of a decline in the urinary excretion of products of the fibrinogen/fibrin cleavage more than two-fold a week after the start of treatment. If no such decline occurs the treatment is to be supplemented by prednizolon and curantil.

[The efficacy of using antiaggregants in chronic glomerulonephritis with grade-I chronic kidney failure]. / Efektivnist' vykorystannia antyahrehantiv pry khronichnomu hlomerulonefryti z I stupenem khronichnoï nyrkovoï nedostatnosti.

Both short-term and long-term effectiveness of xantinole nicotinate as well as trentale and combinations thereof with dipyridamole has been demonstrated in patients with chronic glomerulonephritis presenting with grade 1 chronic renal insufficiency, which fact can be accounted for by their vasoactive and antiaggregant actions. Particular regimens have been developed to treat the medical condition in question with the above drug preparations, comparative evaluation was done of their effects on the clinical course of the illness as well as on the effective renal plasma flow, concentration of nitrogenous remainder in blood and urine, concentration of medium size molecules in blood. It is advisable that antiaggregants be administered long term (from several months to several years).

[The hemostatic system and thrombohemorrhagic complications during the hemosorption treatment of patients with chronic glomerulonephritis with nephrotic syndrome]. / Systema hemostazu i trombohemorahichni uskladnennia pry likuvanni hemosorbtsiieiu khorvykh na khronichnyi hlomerulonefryt z nefrotychnym syndromom.

Effects were studied of hemosorption on the system of homeostasis in patients with chronic glomerulonephritis presenting with nephrotic syndrome. An optimum graphic express method of control of the homeostasis system state was found, permitting predicting thrombohemorrhagic complications after single-session hemosorption (significance 99.9%). Strategies were identified for correction of changes in coagulogrammes in such patients along with devising measures to prevent the above complications.

[The vasoactive action of kurantil in patients with chronic glomerulonephritis]. / Vazoaktyvna diia kurantylu u khvorykh na khromichnyi hlomerulonefryt.

The immediate positive result of 3-4 weeks' course of treatment with curantyl (C) of patients with chronic glomerulonephritis (ChGN) is due to both vasoactive and antiaggregant action of the preparation. The negative immediate result of C treatment appear to be associated with <>. C was found to be usefull in treatment of ChGN patients presenting with predominance of fibroplastic changes in the kydneys, those with arterial hypertension, grade I ChGN. Analysis of late results of treatment 1.5-2 years after C withdrawal revealed improvement in health status in 22.5% and slowing down ChGN progression in 15% of patients compared to the control group.

[The efficacy of kurantil and its effect on thrombocytic hemostasis in patients with chronic glomerulonephritis]. / Efektyvnist' kurantylu ta ioho vplyv na trombotsytarnyi hemostaz u khvorykh na khronichnyi hlomerulonefryt.

The paper treats of the mechanisms of antiaggregant and vasoactive effect of curantyl (C) in chronic glomerulonephritis (ChGN). As many as 85 ChGN C-treated patients were examined; positive treatment effect was seen in 35.5%, negative one in 12.9% of the patients; no effect in 25.8%. It has been ascertained that in some instances prognostically unfavourable forms of ChGN do respond to C treatment. Efficacy of C therapy is predictable from the baseline 24 h proteinuria and decrease in urinary excretion of products of fibrinogen/fibrin degradation during the first week of treatment.

[The effect of membrane-stabilizing therapy on the status of the hemostatic system in patients with glomerulonephritis with a hematuric component]. / Vplyv membranostabilizuiuchoï terapiï na stan hemostazu u khvorykh na hlomerulonefryt z hematurychnym komponentom.

Hyperfibrinogenaemia, hyperthrombinaemia, slowed down lysis of euglobulin clot, increased level of plasminogen, delayed aggregation of thrombocytes were observed in 20 patients with glomerulonephritis with haematuria. Membrane-stabilizing therapy reduced trends to hypercoagulation, significantly improved aggregating abilities of thrombocytes. Considerable impact of membrane-stabilizing therapy on indices of haemostasis in patients with hematuric glomerulonephritis evidences close link to exist between activation of lipid peroxidation, changes of structural and functional parameters of membranes and mechanisms of blood coagulation and thrombocyte aggregation.