ABSTRACT
We investigated two patients with the idiopathic hypereosinophilic syndrome and peripheral neuropathy. Clinical, EMG, and pathological findings were consistent with axonal polyneuropathy. Morphologic changes of the nerve biopsies suggested axonal damage secondary to increased endoneurial pressure from leakage of capillaries. We postulate that endothelial cell damage, followed by nerve edema, is the first step in the pathogenesis of peripheral neuropathy in these patients.
Subject(s)
Eosinophilia/complications , Peripheral Nervous System Diseases/etiology , Biopsy , Capillaries/pathology , Edema/etiology , Edema/physiopathology , Electrophysiology , Eosinophilia/pathology , Eosinophils/pathology , Female , Humans , Male , Middle Aged , Peripheral Nerves/blood supply , Peripheral Nerves/pathology , Peripheral Nerves/physiopathology , Peripheral Nerves/ultrastructure , Peripheral Nervous System Diseases/pathology , Peripheral Nervous System Diseases/physiopathologyABSTRACT
According to the Authors the discussion of the relationships between alcohol and diabetes should be a main step within a "personalized" program for the education of the diabetic patient, especially in region where alcohol consumption is very high and deeply rooted in tradition, habits and social life. Therefore the Authors propose a teaching program based on 6 points, touching the most important aspects. That must be known in order to avoid, at least partially, the short period complications, connected with the relationship between diabetes mellitus and alcohol abuse.
Subject(s)
Alcohol Drinking , Alcoholism/complications , Diabetes Complications , Patient Education as Topic/methods , Diabetes Mellitus/drug therapy , Drug Synergism , Ethanol/adverse effects , Humans , Hypoglycemia/chemically induced , Hypoglycemia/prevention & control , Hypoglycemic Agents/adverse effects , Hypoglycemic Agents/therapeutic use , Life StyleSubject(s)
Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 2/complications , Hypothyroidism/etiology , Adolescent , Adult , Aged , Antibodies/analysis , Diabetes Mellitus/immunology , Humans , Middle Aged , Thyroid Function Tests , Thyroid Gland/immunology , Thyroid Hormones/analysisABSTRACT
The prolactin response to oral metoclopramide (10 mg) was investigated in 53 chronic alcoholics (26 with alcoholic cirrhosis and 27 without evidence of liver disease) from two to seven days after alcohol suspension. The response appeared significantly higher in patients than in healthy controls and was not related to the presence of liver disease. This finding may depend on the deactivation of the dopaminergic activities secondary to alcohol suspension; alternatively, ethanol could have a direct action on prolactin secretion.
