[The role of changes in the structure of water and water-based systems in the mechanism of combined action of the magnetic field and natural therapeutic factors].

The application of the dielectrometric technology in the combination with the resonance method and thermometry has been shown to provide an insight into a variety of factors including the influence of the magnetic field of the permanent magnets on the structure of water and water-containing systems. It was found that the magnetization of both distilled water and «Karachinskaya¼ mineral water increase their structuredness. Magnetization changes the biological properties of therapeutic peloids by virtue of a change in the structure of water and, accordingly, the structuring of the water fraction of therapeutic muds. The analysis of the results of experimental and theoretical studies gives evidence that variations in the structure of water and water-based systems play an important role in enhancing the effectiveness of the combined treatment with the use of the magnetic field and the natural therapeutic factors. The positive and adaptogenic effects of such treatment appears to be due to such changes in the structure of water and water-containing systems which facilitate communication between the processes in the resonant mode but maintain stability of the cellular structures by limiting the mobility of water dipoles under the influence of non-resonant frequencies.

[Reserve of serum lipids for peroxidation during oxidative stress in rats]. / Otsenka rezerva lipidov syvorotki krovi dlia perekisnogo okisleniia v dinamike okislitel'nogo stressa u krys.

The index quantitatively characterizing the serum lipids reserve for peroxidation (SLRP) was developed and evaluated in rats with simulated toxic (CCl4) hepatitis. The index represents a ratio of malondialdehyde (MDA) concentrations in serum before and after stimulation of peroxidation by Fe2+ ions (in the same sample). The index SLRP allows to evaluate direction and the intensity of imbalance among prooxidants action and the total activity of serum lipids antioxidant system even when there is no change of MDA basal level.

[The characteristics of the mechanism of action in the joint use of solutions of brine and mud extracts with galvanization and ultrasonic exposure. 2]. / Osobennosti mekhanizma deistviia sochetannogo primeneniia rastvorov ékstraktov rapy i griazi s gal'vanizatsiei i ul'trazvukovym vozdeistviem. Soobshchenie 2.

Radionuclide tracing has demonstrated that intraperitoneal introduction of natural brine and mud solutions to intact rats followed by ultrasound versus galvanization provides more intensive delivery of chemical elements to the target organs and tissues. These differences should be taken into account when planning rehabilitation schemes with various physiotherapeutic modalities.

[The effect of the combined action of applications of sapropel and of a nonuniform permanent magnetic field on the dynamics of the recovery processes in damage to the liver parenchyma (experimental research)]. / Vliianie sochetannogo vozdeistviia applikatsii sapropelia i neodnorodnogo postoiannogo magnitnogo polia na dinamiku vosstanovitel'nykh protsessov pri povrezhdenii parenkhimy pecheni (éksperimental'noe issledovanie).

Effectiveness of applications of saprol and nonuniform constant magnetic field (NUCMF) used alone and in combination was studied on the model of experimental toxic rat hepatitis. NUCMF had no advantages over saprol in correction of hepatic tissue function. However, combination of these two modalities was more effective than each of them. Possible mechanisms of such effect are discussed.

[A comparative evaluation of the effect of different types of sapropel on dynamic liver function in intact rats and in the modelling of toxic hepatitis]. / Sravnitel'naia otsenka vliianiia raznykh tipov sapropelia na dinamiku funktsional'nogo sostoianiia pecheni intaktnykh krys i pri modelirovanii toksicheskogo gepatita.

A course of silicic sapropel applications compared to calcareous sapropel induced a reversible fall of total lipid concentration in blood serum of intact rats. Sapropels of different kinds and of the same kind but obtained from different depths of the same deposit varied by their ability to correct hepatic function in rats with toxic hepatitis. The highest benefit was registered in application of carbonate sapropels taken from the depth of 1.5-2.5 m.

[The morphofunctional validation of the use of vibration-traction for the correction of contractures of the joints]. / Morfofunktsional'noe obosnovanie primeneniia vibrotraktsii dlia korrektsii kontraktur sustavov.

Experiments in modelling joint contracture have shown that vibrotracture with step-by-step frequency rise in one procedure and discrete rise in traction power in the course of procedures may correct joint contracture. Basing on these experimental findings, the authors have developed highly effective method of vibrotraction treatment of joint contractures (patent N 1804819).

[The anti-arrhythmic effect of the electrophoresis of a natural shirsal preparation in the 2nd-stage rehabilitation of myocardial infarct patients]. / Antiaritmicheskii éffekt élektroforeza prirodnogo preparata shirsala na II étape reabilitatsii bol'nykh infarktom miokarda.

Experimental and clinical trials of antiarrhythmic effect of shirsal (natural salt of lake Shira mineral water) have shown that rehabilitation complex including shirsal electrophoresis is beneficial for MI patients with arrhythmia. Shirsal electrophoresis extends indications for sanatorium treatment of MI patients with stable angina of effort (functional class III-IV), grade I-IV arrhythmia, chronic circulatory insufficiency.

[The efficacy of vibration and traction in correcting contractures of the joints (an experimental study)]. / Effektivnost' vibrotraktsii pri korrektsii kontraktur sustavov (éksperimental'noe issledovanie).

The experiments on rabbits with modelled articular contracture established a marked corrective effect of simultaneous exposure of the rabbits to vibration and traction. Clinical trials in patients with traumas of the peripheral nerves complicated by articular contractures provided evidence for high efficacy of combined rehabilitation including vibration and traction methods.

[The prevention of reperfusion damages to the rat heart by preliminary short-term episodes of ischemia of different durations]. / Preduprezhdenie reperfuzionnykh povrezhdenii serdtsa krys s pomoshch'iu predvaritel'nykh kratkovremennykh épizodov ishemii razlichnoi dlitel'nosti.

Short ischemic episodes of 1 to 5 min duration in the rat isolated heart prevented the reperfusion-induced disturbances of the heart contractile function. 2-3-min ischemic episodes restricted development of arrhythmias and decreased electro-mechanical coupling processes.

[Effect of polyethylene oxide on hemodynamic parameters in infusion therapy of irreversible hemorrhagic shock]. / Vliianie poliétilenoksida na pokazateli gemodinamiki pri infuzionnoi terapii neobratimogo gemorragicheskogo shoka.

Blood loss in 14 anesthetized cats was completely replaced either by polyglucin (control group) or polyglucin with addition of polyethylene oxide (mol. mass 6x10(6)). Blood of the cats contained 2.6-4.4 x 10(6) g/ml of polyethylene oxide. Its introduction promoted advanced recovery of hemodynamic indices and stimulated systemic oxygen transport.

[The characteristics of the mechanism of action in the electro- and ultraphonophoresis of brine and mud preparations]. / Osobennosti mekhanizma deistviia élektro- i ul'trafonoforeza preparatov rapy i griazi.

Rat experiments with short-life radionuclides revealed a marked differences in the action of dry mud extract and dry brine in spite of the fact that their composition was almost similar. Galvanization and ultrasound induce effects acting differently on accumulation of chemical elements from brine and mud in the body and skin of both healthy animals and those with induced diseases. These differences in the action of the above natural compounds of the same type should be considered when planning physiobalneotherapeutic rehabilitation complexes.

[The effect of transcardiac galvanization on energy metabolism and the size of the area of the heart muscle lesion in experimental myocardial infarct]. / Vliianie transkardial'noi gal'vanizatsii na énergeticheskii metabolizm i velichinu zony porazheniia serdechnoi myshtsy pri éksperimental'nom infarkte miokarda.

A study was made of effects of transcardiac galvanization (TCG) on activities of a panel of oxidation-reduction enzymes as well as on the cardiac muscle content of high energy substrates, and size of the lesion area, in experimental myocardial infarction (EMI) in 50 albino male rats. After two TCG procedures, and at 24-h EMI, augmentation was found of activities of succinic dehydrogenase, lactate dehydrogenase, NADH-dehydrogenase, beta-hydroxybutyrate dehydrogenase, both in the area of profound ischemia and peri-infarction myocardium, this being accompanied with an increase in myocardial content of adenosine triphosphate, creatine phosphate, and glycogen, and reduction of the developing mass of necrosis. Stimulation of enzyme activity in the course on the enzyme complex and membrane-stabilizing action of this preformed physical factor.

[Effect of constant electric current on energy metabolism and ultrastructure of the isolated rat heart in the course of its post-ischemic reperfusion]. / Vliianie postoiannogo élektricheskogo toka na énergeticheskii metabolizm i ul'trastrukturu izolirovannogo serdtsa krysy v dinamike ego postishemicheskoi reperfuzii.

It is established, using Langendorff's perfusion method, that the constant current improves the energetic metabolism of the isolated heart during its reoxygenation. The constant current increases the intensity of the succinate oxidation, exerts a membrane stabilizing effect on the cardiomyocytes, stimulates intracellular reparative processes in the damaged myocardium.

[The protective effect of carnosine in hypoxia and reoxygenation of the isolated rat heart]. / Zashchitnoe deistvie karnozina pri gipoksii i reoksigenatsii izolirovanogo serdtsa krysy.

The effect of carnosine (15 mM) on the contractile activity of isolated rat hearts contracting in an isotonic regime (37 degrees C at a 5 Hz stimulation frequency) has been studied. Carnosine added to the perfusing solution had no effect on the contractile activity either in hypoxia or during reoxygenation but decreased it with a simultaneous increase in the coronary flow during reoxygenation. Carnosine inhibited by 60% the lactate dehydrogenase release from cardiac cells. A conclusion is drawn that the protective effect of carnosine is due to its membrane-stabilizing action which is implemented during inhibition of peroxidation of membrane lipids.

[Functional heterogeneity of the atrial myocardium in patients with congenital and acquired heart defects]. / Funktsional'naia geterogennost' miokarda predserdii bol'nykh s vrozhdennymi i priobretennymi porokami serdtsa.

In experiments on atrium trabeculae the heterogeneity of myocardium contractile activity in patients operated on for inborn or acquired heart defects was studied. Contractile activity was assessed in isometric regime of muscle drugs work. The degree of functional heterogeneity was reported to differ in myocardium biopsies from patients with inborn or acquired heart defects. The difference was expressed in susceptibility to stimulating action or electrical impulses and in the degree of the change of myocardium contractile activity. The study of human myocardium functional heterogeneity is likely to present a new approach to increase efficacy of the work of pathologically changed heart muscle.

[The action of fenoptin on cAMP dynamics in the isolated guinea pig heart during contraction-relaxation]. / Deistvie fenoptina na dinamiku tsAMF v izolirovannym serdtse morskoi svinki v protsesse ee sokrasheniia--rasslebleniia.

The influence of finoptin and Ca2+ concentration decrease on cAMP dynamic during cardiac cycle in guinea pig isolated heart, activated by isadrin (3 x 10(-8) M), has been studied. In isadrin activation of adrenoceptors cAMP concentration increased by 50% during contraction and decreased during relaxation. Hypocalcium solution (0.15 mM) and finoptin decreased cAMP concentration and influenced its dynamic during cardiac cycle.