Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters










Publication year range
1.
Fertil Steril ; 94(6): 2118-21, 2010 Nov.
Article in English | MEDLINE | ID: mdl-20189559

ABSTRACT

OBJECTIVE: To analyze oxidative stress markers and seminal standard parameters after using resveratrol (0.1, 1.0, and 10.0 mM), an important antioxidant, in the cryopreservation of human semen. DESIGN: In vitro prospective study. SETTING: Institutional study. PATIENT(S): Infertile and fertile men. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Levels of thiobarbituric acid-reactive species (TBARS), superoxide dismutase (SOD), and catalase (CAT) activities and spermatozoa concentration, motility, and morphology. RESULT(S): Increased TBARS levels were observed in the post-thawing semen in both fertile and infertile men. Infertile men had lower CAT and SOD activities in prefreezing and post-thawing samples when compared with fertile men. The addition of resveratrol in all the concentrations assayed was able to prevent post-thawing lipoperoxidation in both fertile and infertile men. However, this effect was not dose dependent. The cryopreservation process was not able to change sperm concentration or morphology. However, a decrease in sperm motility was observed in both the fertile and infertile men. The addition of resveratrol was not able to prevent this effect. CONCLUSION(S): Resveratrol avoids oxidative damages induced by the cryopreservation of human semen, but it is not able to restore the decrease in sperm motility.


Subject(s)
Cryopreservation/methods , Semen Preservation/methods , Semen/drug effects , Stilbenes/pharmacology , Adult , Antioxidants/pharmacology , Catalase/metabolism , Cryoprotective Agents/pharmacology , Humans , Infertility, Male/metabolism , Male , Oxidative Stress/drug effects , Reactive Oxygen Species/metabolism , Resveratrol , Semen/metabolism , Semen/physiology , Semen Analysis , Young Adult
2.
Hum Fertil (Camb) ; 12(3): 166-71, 2009.
Article in English | MEDLINE | ID: mdl-19925327

ABSTRACT

The follicular fluid environment surrounding the oocytes may play a critical role in fertilization and subsequent embryo development. The goal of our study was to evaluate the oxidative stress markers in the semen, blood serum, and follicular fluid of couples undergoing Intracytoplasmic Sperm Injection (ICSI). Two hundred and eight infertile couples underwent ICSI and the levels of superoxide dismutase (SOD) and catalase and lipid peroxidation (LPO) were evaluated. Semen Catalase was highly correlated with fertilization and cleavage rates, but not with pregnancy rates. Fertilization and cleavage rates were correlated with the levels of SOD and Catalase in the follicular fluid. After adjusting for age, a negative correlation was detected between LPO levels in follicular fluid and pregnancy rates. Follicular fluid LPO levels may be a marker as a metabolic activity within the follicle need for establishing a pregnancy.


Subject(s)
Catalase/metabolism , Follicular Fluid/metabolism , Infertility/metabolism , Semen/metabolism , Superoxide Dismutase/metabolism , Age Factors , Analysis of Variance , Embryo Transfer , Female , Fertilization in Vitro , Humans , Infertility/therapy , Lipid Peroxidation , Male , Pregnancy , Pregnancy Rate , Sperm Injections, Intracytoplasmic
3.
J. bras. med ; 94(1/2): 36-39, jan.-fev. 2008. tab
Article in Portuguese | LILACS | ID: lil-545606

ABSTRACT

A infertilidade afeta até 15 por cento da população sexualmente ativa e em 50 por cento dos casos o fator masculino está envolvido, como problema primário ou em combinação com causas de origem feminina. Como muitas drogas comumente encontradas e medicações podem ter efeitos deletérios na infertilidade masculina, a avaliação médica deve incluir uma discussão sobre o uso de drogas ilícitas, medicamentos e outras substâncias que podem prejudicar a fertilidade. Com oconhecimento de quais drogas e medicamentos podem ser prejudiciais a fertilidade, talvez seja possível mudar os habitos ou a posologia das medicações para diminuir os efeitos adversos na fertilidade e aumentar as chances de engravidar com sucesso.


Infertility affects up to 15 per cent of the sexual active population and in 50 per cento of cases, a male factor is involved either as a primary problem on in combination with a problem in the female partner. Because many commonly encountered drugs and medications can have a detrimental effect on male fertility, the medical evaluation should include a discussion regarding the use of illicit drugs, medications, and other substances that may impair fertility. With the knowledge of which drugs and medications may be detrimental to fertility, it may be possible to modify a patient's habits or medications regimen to decrease adverse effects on fertility and improve the chances of achieving a successful pregnancy.


Subject(s)
Male , Female , Environmental Exposure/adverse effects , Fertility , Infertility, Female/etiology , Infertility, Male/etiology , Infertility/etiology , Infertility/prevention & control , Polychlorinated Biphenyls/adverse effects , Cannabis/adverse effects , Dioxins/adverse effects , Occupational Exposure/adverse effects , Environmental Pollutants/adverse effects , Pesticides/adverse effects , Nicotiana/adverse effects , Substance-Related Disorders/complications
4.
Reprod. clim ; 22: 20-24, 2007.
Article in Portuguese | LILACS | ID: lil-462400

ABSTRACT

Toda alteração da função endócrina ou exócrina do testículo se reflete de alguma maneira em modificações no espermograma, tanto em seus aspectos morfológicos quanto nos funcionais. Daí a importância de um estudo exaustivo do sêmen para avaliar a capacidade reprodutiva do homem. Ao espermograma, que ainda segue sendo a pedra angular para o estudo do homem, tem sido incorporando novos testes diagnósticos. O conceito de que uma boa análise do sêmen é de fundamental importância para a avaliação da fertilidade masculina ainda permanece, apesar de sabemos que o espermograma não pode ser considerado um teste de fertilidade, e sim o primeiro indicador de que o ciclo hormonal e da espermatogênese está sem maiores alterações


Subject(s)
Humans , Male , Andrology/methods , Infertility, Male/diagnosis , Semen/physiology , Spermatogenesis
SELECTION OF CITATIONS
SEARCH DETAIL
...