ABSTRACT
There are at least five types of alterations of consciousness that occur during epileptic seizures: auras with illusions or hallucinations, dyscognitive seizures, epileptic delirium, dialeptic seizures, and epileptic coma. Each of these types of alterations of consciousness has a specific semiology and a distinct pathophysiologic mechanism. In this proposal we emphasize the need to clearly define each of these alterations/loss of consciousness and to apply this terminology in semiologic descriptions and classifications of epileptic seizures. The proposal is a consensus opinion of experienced epileptologists, and it is hoped that it will lead to systematic studies that will allow a scientific characterization of the different types of alterations/loss of consciousness described in this article.
Subject(s)
Epilepsy/diagnosis , Hallucinations/diagnosis , Unconsciousness/diagnosis , Animals , Epilepsy/physiopathology , Hallucinations/physiopathology , Humans , Terminology as Topic , Unconsciousness/physiopathologyABSTRACT
OBJECTIVES: Psychogenic non epileptic seizures (PNES) are challenging conditions to diagnose and manage. Previous workers have investigated the opinion of health care providers towards PNES; still several lacunae remain to be stressed. Amongst health care professionals, opinion of nurses has not been adequately explored. We attempted to identify areas which need more emphasis to provide optimal care to the patients. PATIENTS AND METHODS: We approached 417 health care providers (HCP; primary care, neurology and in-patient nurses) with a questionnaire regarding their opinion of PNES. RESULTS: Total 115 respondents responded to our survey. We found one-thirds of respondent favoured "non-epileptic seizure" as the preferred diagnostic term. Although majority (61%) of responders felt that PNES were involuntary, 48% of nurses felt that PNES are 'fake' and patients have voluntary control over them. Neurologists and nurses expressed high level of confidence in managing patients of PNES. About 1/3rd (35%) of responders did not feel video EEG (vEEG) to be always required for the diagnosis of PNES. Only a minority (15%) of healthcare providers favor unrestricted driving by patients of PNES in setting of ongoing seizures. CONCLUSION: Our findings highlight areas where more emphasis needs to be placed regarding PNES amongst HCPs. More emphasis needs to be placed on the involuntary nature of these episodes within the HCP community. It might be necessary to more strongly address the education of nurses and residents for this condition.
Subject(s)
Health Personnel/psychology , Seizures/diagnosis , Expert Testimony , Health Personnel/statistics & numerical data , Humans , Primary Health Care , Surveys and QuestionnairesABSTRACT
In the last 10-15 years the ILAE Commission on Classification and Terminology has been presenting proposals to modernize the current ILAE Classification of Epileptic Seizures and Epilepsies. These proposals were discussed extensively in a series of articles published recently in Epilepsia and Epilepsy Currents. There is almost universal consensus that the availability of new diagnostic techniques as also of a modern understanding of epilepsy calls for a complete revision of the Classification of Epileptic Seizures and Epilepsies. Unfortunately, however, the Commission is still not prepared to take a bold step ahead and completely revisit our approach to classification of epileptic seizures and epilepsies. In this manuscript we critically analyze the current proposals of the Commission and make suggestions for a classification system that reflects modern diagnostic techniques and our current understanding of epilepsy.
Subject(s)
Epilepsy/classification , Epilepsy/diagnosis , International Classification of Diseases/standards , Practice Guidelines as Topic/standards , Terminology as Topic , Humans , International Classification of Diseases/trends , Societies, Medical/standards , Societies, Medical/trends , United StatesABSTRACT
A 20-year-old woman was admitted for psychosis. On further investigation, she was found to be have viral encephalitis and generalized nonconvulsive seizures. After the seizures were controlled, she remained in a prolonged catatonic state. Repeated intravenous benzodiazepine administration, improved her cognition dramatically. This case emphasizes that catatonia may occur after encephalitis and nonconvulsive seizures.
Subject(s)
Catatonia/etiology , Encephalitis/complications , Epilepsy, Generalized/complications , Alpha Rhythm , Female , Humans , Posture/physiology , Young AdultABSTRACT
This is a case report of a 15-year-old boy who developed benign intracranial hypertension after 3 weeks of levofloxacin intake. The headache, diplopia, and papilledema resolved within a week after levofloxacin was withdrawn. Physicians must be aware that quinolone antibiotics can potentially cause intracranial hypertension.
Subject(s)
Anti-Bacterial Agents/adverse effects , Intracranial Hypertension/chemically induced , Levofloxacin , Ofloxacin/adverse effects , Adolescent , Diplopia/etiology , Headache/etiology , Humans , Male , Orbital Fractures/drug therapySubject(s)
Medication Errors , Phenytoin/adverse effects , Phenytoin/pharmacokinetics , Adult , Aryl Hydrocarbon Hydroxylases/genetics , Aryl Hydrocarbon Hydroxylases/metabolism , Causality , Computer Simulation , Cytochrome P-450 CYP2C9 , Dose-Response Relationship, Drug , Female , Humans , Medication Errors/adverse effects , Medication Errors/prevention & control , Models, Theoretical , Phenytoin/metabolism , Poisoning/etiology , Poisoning/genetics , Polymorphism, GeneticABSTRACT
The authors report the first case of propofol use for the control of non-epileptic involuntary movements in a patient with postviral encephalitis. The withdrawal from propofol was associated with re-emergence of involuntary movements. The patient was maintained on propofol infusion for 6 months while a series of medications were used in an attempt to control the movements. The movements were finally controlled with high doses of phenobarbital, diazepam, and olanzapine, and the propofol was slowly weaned.
Subject(s)
Anticonvulsants/therapeutic use , Dyskinesias/drug therapy , Propofol/therapeutic use , Adult , Dyskinesias/etiology , Encephalitis, Viral/complications , Female , HumansSubject(s)
Brain/surgery , Dominance, Cerebral/physiology , Encephalitis/surgery , Epilepsy/surgery , Language Development , Adolescent , Age Factors , Child , Encephalitis/complications , Epilepsy/etiology , Female , Functional Laterality/physiology , Humans , Male , Neuronal Plasticity/physiology , Neuropsychological Tests , Postoperative Period , Wechsler ScalesABSTRACT
PURPOSE: To investigate the tolerability and pharmacokinetics of oral loading with lamotrigine (LTG) among epilepsy patients after temporary drug discontinuation in an epilepsy monitoring unit. METHODS: We conducted a pilot study among epilepsy patients (18 years or older) receiving maintenance doses of LTG. LTG was discontinued on admission and restarted at the end of epilepsy monitoring. LTG was given as a single oral dose calculated based on the population expected volume of distribution (Vd, 1.0 L/kg) and target blood level on admission. Baseline and serial blood levels of LTG were determined hourly for 10 to 12 h after the loading dose. OUTCOME MEASURES: (a) frequency of patients with side effects; (b) time to maximum concentration (Tmax), maximum concentration (Cmax), actual volume of distribution, and half-life. RESULTS: Twenty-four patients received a single oral load of LTG (mean, 6.5 +/- 2.7 mg/kg). Overall, LTG loading was well tolerated with no serious adverse events or skin rash observed. Two patients had transient and mild nausea 1 to 2 h after the oral load. The mean estimated pharmacokinetic parameters are as follows: Tmax, 3.1 +/- 2.1 h; Cmax, 8.2 +/- 6.5 mg/L; Vd, 1.1 +/- 1.0 L/kg; clearance, 0.08 +/- 0.08 mg/L/h; half-life, 22 +/- 30 h. All patients reached their target blood levels. CONCLUSIONS: Epilepsy patients temporarily discontinued from LTG can be restarted with a single oral loading dose. This was well tolerated, and therapeutic levels can be achieved within 1 to 3 h.
