The use of tenoten and tenoten (pediatric formulation) as a drug for premedication in adults and children during outpatients dentist visit.

The use of tenoten and tenoten (pediatric formulation) for premedication in adults and children before dental treatment reduces patient anxiety; the effect is comparable with that of classical anxiolytics and is not accompanied by side effects. These preparations can be recommended for wide use in dentistry.

[Combined action of mexidol and non-narcotic analgesics on pain thresholds and emotional stress behavior in animals].

The influence of non-narcotic analgesics analgin and pentalgin in the basic pharmacological effects of diazepam and mexidol has been studied in outbred male albino rats. It is established that both analgesics do not influence the activity of diazepam. At the same time, they potentiate the analgesic action of mexidol without influencing its antistress action and not inducing any side effects. The strengthening influence of pentalgin was more pronounced. It is concluded that mexidol can be administered in combination with non-narcotic analgesics, in particular with pentalgin, for relieving painful syndrome on the background of stress.

[Mexidol effects in extreme conditions (experiments with animals)].

In extreme conditions like a new situation, bright light, open space, immobilization, height (the open field and lifted cruciform labyrinth test) and a conflict between an unavoidable action and fear of painful mexidol at the doses of 50 and 100 mg/kg of a body weight eliminates anxiety and fear in rats, recovers adequate reactions and the orientative-trying behavior, and lessens aggressiveness. Mexidol extends life span of mice in acute hypoxic conditions. Mexidol is highly competitive with diazepam as an anti-stress agent and excels it as an anti-hypoxic agent; in contrast to diazepam, mexidol does not cause sedation and myorelaxation. Based on these findings, mexidol can be prescribed to humans to maintain efficiency in all kinds of extreme situations.

[Effect of typical and atypical anxiolytics on the behavior and electrophysiological parameters of rats with model cerebrovascular pathology]. / Vliianie anksiolitikov na povedenie i élektrophiziologicheskie pokazateli krys pri sosudistoi patologii mozga.

The influence a series of anxiolytics (tranquilizers) on behavioral disturbances was studied in outbread white male rats with cerebrovascular pathology modeled by ligation of common carotid arteries. All studied anxiolytics (diazepam, buspirone, mexidol) exhibited more of less pronounced protective action with respect to the pathology studied. The most significant protective effect was produced by the atypical anxiolytic mexidol. Special features of the effect of mexidol are probably explained by combination of several effects (anxiolytic, nootrope, antioxidant, and antihypoxant). in the pharmacological activity spectrum of this drug.

[Instrumental evaluation of sensory thresholds in subjects with different pain sensitivity]. / Instrumental'naia otsenka sensornykh porogov u lits s razlichnoi iskhodnoi bolevoi chuvstvitel'nost'iu.

Will the aid of a modified apparatus the authors determined the sensory thresholds of tactile, and pain sensitivity, and the limit of pain tolerance. Subject to measurement were 500 persons. By the nature of the initial high sensitivity (minor thresholds), moderate (medium) and low (major thresholds) ones. The effect of taking by mouth metherasine (0.025) and amidopyrine with analgin (0.25 each) was analyzed in each group. It was ascertained that the mechanism of their action, produced the greatest effect in persons with an initially elevated sensitivity to pain stimulators. Metherasine changed to a greater extent the pain tolerance thresholds, whereas amidopyrin with analgin did the same with the pain thresholds. In individuals with an initially elevated pain sensitivity both the pain threshold and that or the pain tolerance were higher. These date are of importance for rational approach to an individual choice of substances to be prescribed with a different attitude to pain.

[Antioxidant Mexidol premedication of patients with periodontitis during antihomotoxic therapy]. / Premedikatsiia antioksidantom meksidolom na fone antigomotoksicheskoi terapii u bol'nykh parodontitom.

The tranquilizing effect of antioxidant mexydol on 95 patients with chrconic generalized parodontitis against a background of various somatic diseases was evaluated. The anxiety and the efficiency of premedication were accessed according to Korach's and Spilberger's scales and according to the special psychological questionnaire. The quantitative characteristics of premedication were given baised on the psychological tests results. There was registered a definite improvement of health characteristics and of patient's mood in comparison to the initial input data as well as lower lever of their situational anxiety. This proves the tranquilizing effect of premedication with mexidol (5% amp.). The most evident dynamics of these changes can be observed among patients suffering from high initial anxiety level. The findings of the study are based on more than 2 year old history of treatment of 30 patients with traumel. 21 patients suffering from disfunction of the nervous system were given some comprehensive treatment (traumel locally orally and mexidol in injections). The clinical effect resulted in emotional stabilization of patients and reduced the time needed for their clinical treatment. The medicines were combined. No side effects were observed.

[The use of antihomotoxic therapy in dentistry]. / Primenenie antigomotoksicheskoi terapii v stomatologii.

Efficacy of traumel C is assessed in patients with various maxillofacial inflammations. Sixty-nine patients with diseases of the buccal mucosa (aphthous stomatitis, herpes labialis, and perlèches), periodontal tissues, and painful syndrome after dental canal filling were treated. Applications of the drug were administered to patients with diseases of the buccal mucosa and slight or medium-severe periodontitis. Patients with grave periodontitis and pain after dental canal filling were injected with traumel solution. Positive shifts were attained in all cases. The duration of treatment depended on the process severity. The results recommend traumel C as an ointment for local applications and an injection solution for combined therapy of diseases of the buccal mucosa and periodontitis. The treatment schemes are convenient for outpatient treatment; there are no contraindications precluding the drug use. No side effects were observed.

[A comparison of the effect of tranquilizers in experiments and clinical practice]. / Sravnenie éffekta trankvilizatorov v éksperimente i klinicheskoi praktike.

Experimental and clinical study of the analgesic effects of mebicar and benzodiazepine series tranquilizers (sibazon and chlozepid) and their combinations with non-narcotic analgesics (amidopyrin, pyranal) or local anesthetic lidocaine has demonstrated a more marked effect of benzodiazepine derivatives on pain sensitivity thresholds as against mebicar. Tranquilizer combinations with other analgesics helped define the optimal premedication variants: benzodiazepine derivative augment analgesic activity whereas mebicar potentiates lidocaine effect.

[The use of fluorine-containing coatings for isolating fissures of the molars and premolars to prevent caries]. / Primenenie ftorsoderzhashchikh pokrytii dlia izoliatsii fissur moliarov i premoliarov v tseliakh profilaktiki kariesa.

Experimental and clinical investigations were performed to assess the caries-preventing potencies of hermetic covering with Epoxylite-9075 (USA) and vitacryl (USSR) insulating the intact fissures in molars and premolars. Intact sheathing is capable of protecting the tooth against caries for a long time. Fluoride as a component of the material increased the enamel caries-resistance.