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1.
J Biomed Mater Res B Appl Biomater ; 109(5): 733-743, 2021 05.
Article in English | MEDLINE | ID: mdl-33073509

ABSTRACT

There is a growing demand for polymer fiber scaffolds for biomedical applications and tissue engineering. Biodegradable polymers such as polycaprolactone have attracted particular attention due to their applicability to tissue engineering and optical neural interfacing. Here we report on a scalable and inexpensive fiber fabrication technique, which enables the drawing of PCL fibers in a single process without the use of auxiliary cladding. We demonstrate the possibility of drawing PCL fibers of different geometries and cross-sections, including solid-core, hollow-core, and grooved fibers. The solid-core fibers of different geometries are shown to support cell growth, through successful MCF-7 breast cancer cell attachment and proliferation. We also show that the hollow-core fibers exhibit a relatively stable optical propagation loss after submersion into a biological fluid for up to 21 days with potential to be used as waveguides in optical neural interfacing. The capacity to tailor the surface morphology of biodegradable PCL fibers and their non-cytotoxicity make the proposed approach an attractive platform for biomedical applications and tissue engineering.


Subject(s)
Biocompatible Materials/chemistry , Polyesters/chemistry , Tissue Engineering/methods , Calorimetry, Differential Scanning , Cell Line, Tumor , Cell Proliferation , Hot Temperature , Humans , MCF-7 Cells , Materials Testing , Polymers , Stress, Mechanical , Temperature , Tissue Scaffolds
2.
Opt Express ; 20(11): 11924-35, 2012 May 21.
Article in English | MEDLINE | ID: mdl-22714178

ABSTRACT

We characterize spatial dispersion in longitudinally invariant drawn metamaterials with a magnetic response at terahertz frequencies, whereby a change in the angle of the incident field produces a shift in the resonant frequency. We present a simple analytical model to predict this shift. We also demonstrate that the spatial dispersion is eliminated by breaking the longitudinal invariance using laser ablation. The experimental results are in agreement with numerical simulations.


Subject(s)
Magnets , Models, Theoretical , Computer Simulation , Magnetic Fields , Radiation Dosage
3.
Opt Lett ; 34(24): 3890-2, 2009 Dec 15.
Article in English | MEDLINE | ID: mdl-20016648

ABSTRACT

Surface plasmon resonance (SPR) is demonstrated in a microstructured optical fiber sensor for the first time (to our knowledge). SPR features were observed at 560 and 620 nm when sample fluids of refractive indices n=1.38 and n=1.41, respectively, were applied to the sensor. This study also identifies a new approach to improve the resolution of fiber SPR sensors.


Subject(s)
Fiber Optic Technology/instrumentation , Surface Plasmon Resonance/instrumentation , Transducers , Computer-Aided Design , Equipment Design , Equipment Failure Analysis , Reproducibility of Results , Sensitivity and Specificity
4.
J R Soc Interface ; 6 Suppl 2: S233-42, 2009 Apr 06.
Article in English | MEDLINE | ID: mdl-18980932

ABSTRACT

Regular three-dimensional periodic structures have been observed in the scales of over half a dozen butterfly species. We compare several of these structures: we calculate their photonic bandgap properties; measure the angular variation of the reflection spectra; and relate the observed iridescence (or its suppression) to the structures. We compare the mechanisms for iridescence suppression in different species and conclude with some speculations about form, function, development and evolution.


Subject(s)
Butterflies/physiology , Optical Phenomena , Wings, Animal/physiology , Animals , Behavior, Animal/physiology , Biological Evolution , Butterflies/genetics , Species Specificity
5.
Appl Opt ; 47(29): 5235-41, 2008 Oct 10.
Article in English | MEDLINE | ID: mdl-18846161

ABSTRACT

This paper examines evidence for the hypothesized connection between solar thermal properties of butterfly and moth (Lepidoptera) wings, iridescence/structural color, and thermoregulation. Specimens of 64 species of Lepidoptera were measured spectrophotometrically, their solar absorptances calculated, and their habitat temperatures determined. No correlation was found between habitat temperature and the solar absorptance of the wings. It was found, however, that the iridescent specimens exhibited, on average, substantially higher solar absorptance than noniridescent ones.


Subject(s)
Body Temperature Regulation , Butterflies/physiology , Color , Moths/physiology , Wings, Animal/physiology , Absorption , Animals , Ecosystem , Spectrophotometry , Sunlight , Temperature
6.
Opt Lett ; 33(9): 902-4, 2008 May 01.
Article in English | MEDLINE | ID: mdl-18451933

ABSTRACT

A hollow-core microstructured polymer optical fiber was analyzed in the terahertz (THz) region. Spectral analysis of time domain data shows propagation of THz waves in both the hollow-core and the microstructured cladding with a time delay of approximately 20 ps. The frequency range and shift of the transmission bands between different sized waveguides suggested photonic bandgap or resonant guidance. Finite-difference time domain calculations agree relatively well to the experimental transmission results. Propagation losses were estimated to be as low as 0.9 dB/cm.

7.
Opt Express ; 16(23): 18590-8, 2008 Nov 10.
Article in English | MEDLINE | ID: mdl-19581944

ABSTRACT

We investigate the bend loss of highly multimode air-clad microstructured polymer optical fibre which displays low bend loss for small bend radii. After repeated bending the loss approached a plateau, decreasing significantly after a characteristic length. The loss at a particular point depended on the configuration of the fibre preceding that point. A simple analytical model based on a transfer-matrix method is derived to explain this behaviour in terms of the power distribution amongst different mode groups. This model allows the effect of a particular fibre configuration to be predicted.


Subject(s)
Models, Theoretical , Optical Fibers , Computer Simulation , Computer-Aided Design , Energy Transfer , Equipment Design , Equipment Failure Analysis , Light , Reproducibility of Results , Scattering, Radiation , Sensitivity and Specificity
8.
Opt Express ; 15(14): 8844-50, 2007 Jul 09.
Article in English | MEDLINE | ID: mdl-19547221

ABSTRACT

We report on the thermal characteristics of Bragg gratings fabricated in polymer optical fibers. We have observed a permanent shift in the grating wavelength at room temperature which occurs when the grating has been heated above a threshold temperature. This threshold temperature is dependent on the thermal history of the grating, and we attribute the effect to a shrinking of the fiber. This effect can be avoided by annealing the fiber before grating inscription, resulting in a linear response with temperature and an increased linear operating temperature range of the grating.

9.
Opt Express ; 15(19): 11843-8, 2007 Sep 17.
Article in English | MEDLINE | ID: mdl-19547546

ABSTRACT

A unique optical fibre design is presented in this work: a laterally accessible microstructured optical fibre, in which one of the cladding holes is open to the surrounding environment and the waveguide core exposed over long lengths of fibre. Such a fibre offers the opportunity of real-time chemical sensing and biosensing not previously possible with conventional microstructured optical fibres, as well as the ability to functionalize the core of the fibre without interference from the cladding. The fabrication of such a fibre using PMMA is presented, as well as experimental results demonstrating the use of the fibre as a evanescent wave absorption spectroscopy pH sensor using the indicator Bromothymol Blue.

10.
Opt Express ; 15(21): 13675-81, 2007 Oct 17.
Article in English | MEDLINE | ID: mdl-19550638

ABSTRACT

Improvement of surface enhanced resonant Raman scattering (SERRS) signals is demonstrated by confining the scattering event to the core of a hollow core microstructured optical fiber. The analyte solution fills the entire microstructure. The pump light is guided in the liquid core and the Raman scattered signal is efficiently collected by the fiber and transmitted to the detector. Rhodamine 6G (210nM) adsorbed on silver nanoparticles in aqueous solution is used as a demonstration system and it was found that it is possible to collect usable Raman signals from the solution filled optical fiber well beyond the detection limit of an equivalent free-space system.

11.
J R Soc Interface ; 3(6): 99-108, 2006 Feb 22.
Article in English | MEDLINE | ID: mdl-16849221

ABSTRACT

Many butterfly species possess 'structural' colour, where colour is due to optical microstructures found in the wing scales. A number of such structures have been identified in butterfly scales, including three variations on a simple multi-layer structure. In this study, we optically characterize examples of all three types of multi-layer structure, as found in 10 species. The optical mechanism of the suppression and exaggeration of the angle-dependent optical properties (iridescence) of these structures is described. In addition, we consider the phylogeny of the butterflies, and are thus able to relate the optical properties of the structures to their evolutionary development. By applying two different types of analysis, the mechanism of adaptation is addressed. A simple parsimony analysis, in which all evolutionary changes are given an equal weighting, suggests convergent evolution of one structure. A Dollo parsimony analysis, in which the evolutionary 'cost' of losing a structure is less than that of gaining it, implies that 'latent' structures can be reused.


Subject(s)
Adaptation, Physiological/genetics , Biological Evolution , Butterflies/physiology , Color , Models, Genetic , Skin Physiological Phenomena , Wings, Animal/physiology , Animals , Colorimetry , Computer Simulation , Genetics, Population , Quantitative Trait, Heritable , Refractometry/methods , Selection, Genetic , Suppression, Genetic/genetics
12.
Opt Lett ; 31(2): 172-4, 2006 Jan 15.
Article in English | MEDLINE | ID: mdl-16441020

ABSTRACT

We have fabricated microstructured polymer optical fibers that guide light in a hollow core using the photonic bandgap mechanism. The hollow core allows the use of polymer fibers to be extended to wavelength ranges where material absorption typically prohibits their use, with attenuation lower than the material loss observed in the infrared. The fabrication method is similar to other microstructured polymer optical fibers, which has favorable implications for the feasibility of manufacturing such bandgap fibers.

13.
Opt Express ; 14(26): 13056-66, 2006 Dec 25.
Article in English | MEDLINE | ID: mdl-19532201

ABSTRACT

The development of microstructured fibres offers the prospect of improved fibre sensing for low refractive index materials such as liquids and gases. A number of approaches are possible. Here we present a new approach to evanescent field sensing, in which both core and cladding are microstructured. The fibre was fabricated and tested, and simulations and experimental results are shown in the visible region to demonstrate the utility of this approach for sensing.

14.
Opt Lett ; 30(24): 3296-8, 2005 Dec 15.
Article in English | MEDLINE | ID: mdl-16389810

ABSTRACT

We report observations and measurements of the inscription of fiber Bragg gratings (FBGs) in two different types of microstructured polymer optical fiber: few-mode and an endlessly single mode. Contrary to the FBG inscription in silica microstructured fiber, where high-energy laser pulses are a prerequisite, we have successfully used a low-power cw laser source operating at 325 nm to produce 1 cm long gratings with a reflection peak at 1570 nm. Peak reflectivities of more than 10% have been observed.

15.
Opt Lett ; 29(12): 1336-8, 2004 Jun 15.
Article in English | MEDLINE | ID: mdl-15233427

ABSTRACT

We report the fabrication of what are believed to be the first microstructured optical fibers with uniformly oriented elliptical holes. A high degree of hole ellipticity is achieved with a simple technique that relies on hole deformation during fiber draw. Both form and stress-optic birefringence are characterized over a broad wavelength range. These measurements are in excellent agreement with numerical modeling and demonstrate a birefringence as high as 1.0 x 10(-4) at a wavelength of 850 nm.

16.
Opt Lett ; 29(8): 818-20, 2004 Apr 15.
Article in English | MEDLINE | ID: mdl-15119388

ABSTRACT

A preform sleeving technique is demonstrated that allows the fabrication of single-mode polymer microstructured fiber with the smallest core and hole dimensions yet reported to our knowledge. For a fixed triangular hole pattern a range of fibers is produced by adjustment to the operating conditions of the draw tower. Numerical modeling is carried out for one of the fibers produced with a 570-microm external diameter, a core diameter of 2.23 microm, an average hole diameter of 0.53 microm, and an average hole spacing of 1.38 microm. This fiber was shown to be endlessly single mode.

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