ABSTRACT
A 20-year-old male brown bear (Ursus arctos) with a 20 × 25 cm necrotic mass adjacent to the trachea was diagnosed as having an anaplastic thyroid carcinoma. Metastases were observed in the lungs and one adrenal gland and, histologically, these had anaplastic and follicular carcinoma patterns, respectively. E-cadherin labelling was observed in the adrenal mass only, while N-cadherin immunolabelling was detected in the thyroid gland and lung masses. Thyroid-specific markers (thyroid transcription factor-1, thyroglobulin) were expressed in the adrenal gland metastasis. This case illustrates an example of a primary epithelial-mesenchymal transition (EMT) enabling metastasis to distant organ sites, followed by a mesenchymal-epithelial transition within the adrenal gland microenvironment, allowing invasion and reacquisition of thyroid epithelial cell features. EMTs help to understand the phenomenon of carcinoma cell plasticity in enabling colonization and growth of metastases.
Subject(s)
Epithelial-Mesenchymal Transition , Thyroid Neoplasms/veterinary , Ursidae , Animals , MaleABSTRACT
CONTEXT: Cyanoacetamide is a -CN bearing molecule that is also an amide derivative target molecule in the interstellar medium. AIMS: The aim of our investigation is to analyze the feasibility of a plausible formation process of protonated cyanoacetamide under interstellar conditions and to provide direct experimental frequencies of the ground vibrational state of the neutral form in the microwave region in order to enable its eventual identification in the interstellar medium. METHODS: We used high-level theoretical computations to study the formation process of protonated cyanoacetamide. Furthermore, we employed a high-resolution laser-ablation molecular beam Fourier transform spectroscopic technique to measure the frequencies of the neutral form. RESULTS: We report the first rotational characterization of cyanoacetamide, and a precise set of the relevant rotational spectroscopic constants have been determined as a first step to identifying the molecule in the interstellar medium. We fully explored the potential energy surface to study a gas-phase reaction on the formation process of protonated cyanoacetamide. We found that an exothermic process with no net activation barrier is initiated by the high-energy isomer of protonated hydroxylamine, which leads to protonated cyanoacetamide.
ABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Airway Management/methods , Pharyngostomy/methods , Oropharyngeal Neoplasms/radiotherapy , Radiation Injuries/diagnosisSubject(s)
Airway Management , Carotid Artery Thrombosis/surgery , Myositis/surgery , Pharyngostomy , Radiation Injuries/surgery , Radiotherapy/adverse effects , Carcinoma, Squamous Cell/drug therapy , Carcinoma, Squamous Cell/radiotherapy , Carotid Artery Thrombosis/etiology , Combined Modality Therapy , Female , Humans , Middle Aged , Myositis/etiology , Oropharyngeal Neoplasms/radiotherapy , Radiation Injuries/etiology , Plastic Surgery Procedures , Skin Ulcer/etiology , Skin Ulcer/surgery , Surgical Flaps , Tonsillar Neoplasms/drug therapy , Tonsillar Neoplasms/radiotherapyABSTRACT
Describimos el caso clínico de un niño de 9 años y medio afecto de periodontitis e hiperqueratosis desde los 5 años de edad. Queremos destacar la afectación generalizada de toda la dentición, las alteraciones inmunológicas encontradas y la discreta afectación dermatológica, siendo el cuadro estomatológico el que identifica en su mayor parte la enfermedad. El tratamiento precoz con acitretino puede mejorar tanto la evolución de las lesiones dérmicas como de la periodontitis
We report the case of a nine-and-a-half-year-old boy who had had periodontitis and hyperkeratosis since the age of five. We describe the involvement of the entire dentition, the associated immunological disorders, and the discrete cutaneous findings. This disease is chiefly identified by its stomatologic features. Early treatment with acitretin can improve the outcome of both the skin lesions and the periodontitis
Subject(s)
Male , Child , Humans , Papillon-Lefevre Disease/diagnosis , Acitretin/therapeutic use , Skin Diseases/etiology , Levamisole/therapeutic use , Papillon-Lefevre Disease/drug therapyABSTRACT
No disponible
