[Diagnosis and antibiotic therapy of nosocomial pneumonia in adults: from recommendations to real practice. A review].

Nosocomial pneumonia is a healthcare-associated infection with significant consequences for the patient and the healthcare system. The efficacy of treatment significantly depends on the timeliness and adequacy of the antibiotic therapy regimen. The growth of resistance of gram-negative pathogens of nosocomial pneumonia to antimicrobial agents increases the risk of prescribing inadequate empirical therapy, which worsens the results of patient treatment. Identification of risk factors for infection with multidrug-resistant microorganisms, careful local microbiological monitoring with detection of resistance mechanisms, implementation of antimicrobial therapy control strategy and use of rational combinations of antibacterial drugs are of great importance. In addition, the importance of using new drugs with activity against carbapenem-resistant strains, including ceftazidime/aviabactam, must be understood. This review outlines the current data on the etiology, features of diagnosis and antibacterial therapy of nosocomial pneumonia.

[Significance of static pressure-volume loop for differential diagnostics and optimization of respiratory support in parenchimal respiratory failure].

PURPOSE OF THE STUDY: To determine significance of static pressure-volume loop (PV loop) for differential diagnostics of parenchymal respiratory failure, setting of positive end-expiratory pressure (PEEP) and recruit ability of the lung. MATERIALS AND METHODS: 76 patients (52 males) with parenchymal respiratory failure were included in the study (oxygenation index (PaO2/ FiO2) < 250 torr infiltrates on chest X-ray or CT-scan of the lungs, no data on left ventricular failure). We plot static PV loop by low flow technique in range of 0 to 40 mbar, fixing lower inflection point (LIP), linear compliance (Clin), upper inflection point (UIP), expiratory inflection point (EIP), compliance of linear deflation limb (C defl), hysteresis (Hyst) and volume of PEEP-induced recruitment of the lung (V(peep)). Then we plot another static PV loop with sustained inflation of 40 mbar for 30 seconds, fixing changes in lung volume at 40 mbar. After 10 minutes of sustained inflation we measured changes of oxygenation index. For 69 patient we performed lung CT-scan and defined diffuse (acute respiratory distress syndrome) or local lung injury (pneumonia, atelectasis). RESULTS: LIP value can differentiate diffuse and local lung injury. LIP more than 10 mbar corresponds to diffuse lung injury on CT scan (sensitivity 76%, specificity 85%, AUROC 0.81). LIP cannot predict PEEP-induced alveolar recruitment and changes of PaO2/FiO2 after sustained inflation maneuver (p > 0.05). Empirically set PEEP (by maximum PaO2/FiO2) was much higher than LIP (p < 0.0001), but LIP correlates with empirically set PEEP in diffuse lung injury (rho = 0.642, p = 0.003). Clin cannot differentiate diffuse from local lung injury (p > 0.05), but predicts PEEP-induced alveolar recruitment during static PV loop plotting (rho = 0.493, p < 0.0001). We did not find any statistically significant values of UIP and EIP for differential diagnosis, setting of PEEP or recruit ability of the lung. Hysteresis value (defined as volume difference at 20 mbar between deflation and inflation limbs) cannot predict influence of PEEP setting and sustained inflation maneuver on PaO2/FiO2 changes and recruit ability of the lung (p > 0.05). After static PV loop plotting combined with sustained inflation maneuver recruited volume of the lungs was 350 (250-450) ml. We didn't find significant differences between recruit ability of the diffuse and locally injured lungs (p > 0.05). Recruitment volume has no correlations with all points and segments of static PV loop. CONCLUSIONS: Static PV loop has limited prognostic value for differential diagnostics of diffuse or local lung injury and brings potential harm for setting PEEP according to LIP. LIP more than 10 mbar can predict diffuse lung injury. Clin can predict volume of PEEP-induced recruitment. In diffuse lung injury LIP correlates with empirically set PEEP.

[Significance of static pressure-volume loop and lung computed tomography for differential diagnostics of parenchymal respiratory insufficiency].

UNLABELLED: Purpose of the study was to determine a significance of static pressure-volume loop and lung computed tomography for differential diagnostics of parenchymal lung failure developing during mechanical ventilation. MATERIALS AND METHODS: 75 patients (42 males and 33 females) with acute lung failure due to parenchymal lung injury during mechanical ventilation were included in to the research. Criteria of including into the research were age over 15, ARDS symptoms absence before respiratory support beginning and modified American-European Consensus Conference ARDS criteria presence during mechanical ventilation (AECC ARDS criteria, 1994--PaO2/FiO2 < 250 mmHg). Lung computed tomography (CT), static compliance and plateau measurement were performed in all patients. Static pressure-volume loop was plotted in 23 patients. RESULTS: diffuse alveolar damage was diagnosed by CT in 24.3% of patients and "wet sponge" symptom in 10.7% of patients. Dorsal atelectasis (77.3%) and ventilator-associated pneumonia (VAP) (82.7%) were diagnosed in most of patients with AECC ARDS criteria. Sensitivity and specificity of PaO2/FiO2 ratio were too low for diagnostics of ARDS (AUROC 0.67) Patients with diffuse alveolar damage had plateau pressure 25 mbar (95% CI 22-32), while patients with local lung injury (VAP or atelectasis) had significantly lower plateau pressure--20 mbar (95% CI 18-22) (p = 0.014). Elevation of plateau pressure over 30 mbar predicted diffuse alveolar damage with specificity of 100%. Lower inflection point values on the static pressure-volume loop was higher in patients with diffuse alveolar damage than in patients with local lung injury--12 mbar (95% CI 7-17) vs. 6 mbar (95% CI 5-10), (p = 0.042, n = 23). Effective (linear) compliance had poor prognostic value for differential diagnostics of acute respiratory failure due to parenchimal lung injury (p = 0.023). CONCLUSION: Lung CT plays leading role in differential diagnostics of parenchymal lung failure developing during mechanical ventilation. In the luck of CT scan elevation of plateau pressure over 30 mbar and values of lower inflection point on the static pressure-volume loop over 12 mbar can predict ARDS.