ABSTRACT
A toxicological evaluation of a new insecticide Sonet was realized. It was established that by its toxicity Sonet belongs to hazardous substances of class III. The main manifestations of its toxic effect on the body warm-blooded animals is its influence on the erythropoiesis and functional state of the liver.
Subject(s)
Benzamides/toxicity , Insecticides/toxicity , Acute Disease , Animals , Benzamides/poisoning , Dose-Response Relationship, Drug , Insecticides/poisoning , Lethal Dose 50 , Phenylurea Compounds , Poisoning/blood , Rats , Time FactorsSubject(s)
B-Lymphocytes/immunology , Hexachlorocyclohexane/toxicity , Phagocytosis/drug effects , T-Lymphocytes/drug effects , T-Lymphocytes/immunology , Animals , Dose-Response Relationship, Drug , Hexachlorocyclohexane/administration & dosage , Immune Tolerance/drug effects , Immune Tolerance/immunology , In Vitro Techniques , Leukocyte Count/drug effects , Phagocytosis/immunology , Rabbits , Rats , Time FactorsABSTRACT
A study is presented of 63 patients with pulmonary tuberculosis suffering of chronic alcoholism. Examination of the activated recalcification time, thrombin and prothrombin time, plasma fibrinogen level, fibrinolytic activity of the blood, ethanol and protaminsulfate tests, fibrin-stabilizing factor, autocoagulation test revealed in most of these patients significant disorders of the coagulation activity suggesting predisposition to intravascular blood coagulation.
Subject(s)
Alcoholism/blood , Blood Coagulation , Fibrinolysis , Tuberculosis, Pulmonary/blood , Adult , Blood Coagulation Tests , Humans , Middle AgedSubject(s)
Blood/drug effects , Chemical Industry , Coloring Agents/adverse effects , Adolescent , Adult , Blood Cell Count , Coloring Agents/chemical synthesis , Dust , Female , Hematologic Diseases/chemically induced , Humans , Male , Middle Aged , Occupational Diseases/chemically induced , UkraineABSTRACT
The experiment involved an investigation into the action of O,O-dimethyl-S-(N-methyl-carbomoilmethyl)-dithiophosphate (phosphamide), used at the level of the liminal dose (4 mg/kg) and in a concentration of 1.9 mg/m3, as compared with the effect of 1/2 of the liminal dose and 1/2 of the thereshold concentration. Both were simultaneously introduced into the organism of test albino rats for a period of 4 months and their complex action showed an intensification of the toxic effect. In evidence was also a more marked anticholinesterase action, a higher level of the insecticide in biological substrates and greater changes of hematological indices.
