ABSTRACT
INTRODUCTION AND AIMS: Colorectal cancer is the most frequent malignant tumor of the digestive system. Its pathogeny is complex and involves the APC/ß-catenin sequence. Lymph node metastases are a significant indicator for determining treatment and are a prognostic factor. SOX9 overexpression is related to oncogenic qualities and the capacity for metastasis. Our aim was to analyze SOX9 immunoexpression in primary colorectal cancer and lymph node metastasis status. MATERIAL AND METHODS: Seventy-nine available cases were divided into the group with lymph node metastasis (n=38) and the group without lymph node metastasis (n=41), evaluating their SOX9 expression. The IBM SPSS version 27 program in Spanish was utilized to carry out the statistical analysis, obtaining measures of central tendency, the kappa index, standard deviation, Wilcoxon Mann-Whitney nonparametric measurements, Spearman's correlation coefficient, and chi-square test and Student's t test values. SOX9 immunoexpression was evaluated through the mean-based H-score, with high immunoexpression as a score ≥145 and low immunoexpression as a score ≤144. RESULTS: A p=0.73 was obtained that was not statistically significant, regarding the relation of SOX9 expression in primary colorectal cancer to lymph node metastasis. CONCLUSIONS: The absence or presence of lymph node metastasis was independent from SOX9 immunoexpression in primary colorectal cancer. However, due to the limited size of the population analyzed, further research is needed.
Subject(s)
Humans , Female , Middle Aged , Darier Disease/diagnosis , Darier Disease/surgery , CryosurgerySubject(s)
Humans , Female , Middle Aged , Darier Disease/diagnosis , Darier Disease/surgery , CryosurgerySubject(s)
Humans , Male , Adult , Dermoscopy/methods , Tinea Pedis/diagnostic imaging , Foot Dermatoses/diagnostic imagingSubject(s)
Hyperpigmentation , Nevus, Sebaceous of Jadassohn , Nevus , Skin Neoplasms , Humans , Skin Neoplasms/diagnosis , SyndromeABSTRACT
La dermatosis ampollar IgA lineal es una enfermedad vesicoampollar subepidérmica, adquirida, mediada por inmunoglobulinas. Presentamos nuestra serie con el objetivo de describir las características clínicas, evolución y tratamientos instaurados. Se realizó un estudio descriptivo, observacional retrospectivo. Se incluyeron 17 pacientes. Como antecedentes 2 niños recibieron vacunas 2 semanas antes del inicio de los síntomas; en 2 casos la enfermedad estuvo precedida por cuadros respiratorios broncoobstructivos. Un paciente recibió antibioticoterapia endovenosa antes del inicio del cuadro. Hallamos asociación con hepatitis autoinmune en un caso y con alopecia areata en otro. Un niño padecía asociación VACTERL. El diagnóstico se confirmó con histopatología e inmunofluorescencia directa. Como tratamiento 16 pacientes recibieron dapsona, 8 de ellos asociaron corticoides orales y 2 esteroides tópicos. Destacamos la presencia de rebrotes con compromiso perioral ante cuadros infecciosos e inmunizaciones, la asociación con síndrome de VACTERL y con hepatitis autoinmune
Linear IgA bullous dermatosis is an acquired subepidermal immunoglobulin-mediated vesiculobullous disease. In this retrospective, observational, descriptive study, we describe the clinical characteristics, treatments, and outcomes of 17 patients with linear IgA bullous dermatosis. Two children had been vaccinated 2 weeks before the onset of symptoms, 2 had had bronco-obstructive respiratory symptoms, and 1 had received intravenous antibiotic therapy. We also observed an association with autoimmune hepatitis in one patient and alopecia areata in another. One boy had VACTERL association. Diagnosis was confirmed by histopathology and direct immunofluorescence. Sixteen patients were treated with dapsone, which was combined with oral corticosteroids in 8 cases and topical corticosteroids in two. Of note in this series was the occurrence of relapses in the perioral area coinciding with infections and vaccination, and the association between linear IgA bullous dermatosis and autoimmune hepatitis and VACTERL association
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Linear IgA Bullous Dermatosis/diagnosis , Linear IgA Bullous Dermatosis/drug therapy , Facial Dermatoses/drug therapy , Foot Dermatoses/drug therapy , Leg Dermatoses/drug therapy , Epidemiology, Descriptive , Retrospective Studies , Linear IgA Bullous Dermatosis/pathology , Dapsone/therapeutic use , Adrenal Cortex Hormones/therapeutic use , Steroids/therapeutic use , Administration, Topical , Fluorescent Antibody Technique, Indirect/methods , Diagnosis, DifferentialABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Skin Diseases, Papulosquamous/pathology , Skin Diseases, Papulosquamous/diagnosis , Skin Diseases, Papulosquamous/epidemiology , Diagnosis, Differential , Peru/epidemiology , Argentina/epidemiologyABSTRACT
Linear IgA bullous dermatosis is an acquired subepidermal immunoglobulin-mediated vesiculobullous disease. In this retrospective, observational, descriptive study, we describe the clinical characteristics, treatments, and outcomes of 17 patients with linear IgA bullous dermatosis. Two children had been vaccinated 2 weeks before the onset of symptoms, 2 had had bronco-obstructive respiratory symptoms, and 1 had received intravenous antibiotic therapy. We also observed an association with autoimmune hepatitis in one patient and alopecia areata in another. One boy had VACTERL association. Diagnosis was confirmed by histopathology and direct immunofluorescence. Sixteen patients were treated with dapsone, which was combined with oral corticosteroids in 8 cases and topical corticosteroids in two. Of note in this series was the occurrence of relapses in the perioral area coinciding with infections and vaccination, and the association between linear IgA bullous dermatosis and autoimmune hepatitis and VACTERL association.
Subject(s)
Linear IgA Bullous Dermatosis , Adrenal Cortex Hormones/therapeutic use , Child , Child, Preschool , Dapsone/therapeutic use , Dermatologic Agents/therapeutic use , Female , Fluorescent Antibody Technique, Direct , Humans , Infant , Linear IgA Bullous Dermatosis/diagnosis , Linear IgA Bullous Dermatosis/drug therapy , Linear IgA Bullous Dermatosis/etiology , Linear IgA Bullous Dermatosis/pathology , Male , Retrospective StudiesSubject(s)
Skin Diseases, Vesiculobullous/pathology , Child , Child, Preschool , Female , Humans , Infant , MaleABSTRACT
El síndrome de Iso-Kikuchi, onicodisplasia congénita del dedo índice, es una entidad poco frecuente caracterizada por la anoniquia total o displasia de la uña del dedo índice, acompañado, en algunas ocasiones, de alteraciones óseas subyacentes, por lo general, en ausencia de otras anomalías. Si bien se han planteado distintas hipótesis fisiopatogénicas, la etiología sigue siendo desconocida. Describimos los casos de 3 pacientes pediátricos, 2 varones y una niña, con alteraciones ungueales y óseas compatibles con el síndrome de Iso-Kikuchi. Destacamos la importancia de reconocer esta entidad tempranamente para evitar la realización de estudios complementarios y terapéuticas innecesarias
Iso-Kikuchi syndrome, or congenital onychodysplasia of the index finger, is an uncommon condition characterized by total anonychia or dysplasia of the nail of the index finger. It is occasionally accompanied by underlying bone abnormalities and is rarely associated with other conditions. Although various hypotheses have been put forward to explain the pathophysiology of the syndrome, its etiology remains unknown. We report the cases of 3 pediatric patients (2 boys and 1 girl) with nail changes and bone abnormalities consistent with Iso-Kikuchi syndrome. We highlight the importance of recognizing this entity early to avoid the need for additional tests and unnecessary treatment
Subject(s)
Humans , Male , Female , Child, Preschool , Nail Diseases/congenital , Finger Phalanges/abnormalities , Nail Diseases/diagnosis , Syndrome , Diagnosis, Differential , OsteogenesisABSTRACT
Iso-Kikuchi syndrome, or congenital onychodysplasia of the index finger, is an uncommon condition characterized by total anonychia or dysplasia of the nail of the index finger. It is occasionally accompanied by underlying bone abnormalities and is rarely associated with other conditions. Although various hypotheses have been put forward to explain the pathophysiology of the syndrome, its etiology remains unknown. We report the cases of 3 pediatric patients (2 boys and 1 girl) with nail changes and bone abnormalities consistent with Iso-Kikuchi syndrome. We highlight the importance of recognizing this entity early to avoid the need for additional tests and unnecessary treatment.
Subject(s)
Nail Diseases/congenital , Child, Preschool , Female , Humans , Male , Nail Diseases/diagnosis , SyndromeABSTRACT
No disponible
Subject(s)
Humans , Female , Adolescent , Pemphigus/diagnosis , Pemphigus/drug therapy , Pemphigus/pathology , Methylprednisolone/therapeutic use , Adrenal Cortex Hormones/therapeutic use , Diagnosis, Differential , Prednisone/therapeutic use , Erythema/complications , Fluorescent Antibody Technique, Direct/instrumentationSubject(s)
Pemphigus/diagnosis , Acantholysis/etiology , Adolescent , Epidermis/immunology , Epidermis/pathology , Female , Fluorescent Antibody Technique, Direct , Humans , Immunoglobulin G/analysis , Methylprednisolone/therapeutic use , Pemphigus/drug therapy , Pemphigus/immunology , Pemphigus/pathology , Pruritus/etiologyABSTRACT
El síndrome de Apert o acrocefalosindactilia tipo I, es un trastorno congénito de herencia autosómica dominante, aunque se han descripto casos de mutación espontánea. Se caracteriza por malformaciones craneofaciales, y sindactilia de manos y pies. En menor proporción hay alteraciones cutáneas, cardiovasculares, genitourinarias, gastrointestinales y respiratorias. Comunicamos el caso de un paciente de 34 años con manifestaciones clínicas de este síndrome y resaltamos el compromiso cutáneo. Revisamos la bibliografía existente al respecto
Subject(s)
Humans , Male , Adult , Acrocephalosyndactylia , Acne Vulgaris , Acrocephalosyndactylia , Alopecia , Heart Defects, Congenital/etiology , Intellectual Disability , Skin Diseases , SyndactylyABSTRACT
Presentamos dos pacientes con una nueva forma clínica de dermatitis en la zon del pañal,El dato clínico mas revelante ha sido su particular localización en la cara lateral de cadera y glúteo,así como su morfología triangular invertida.En ambos pacientes se realizó la prueba del parche y se estableció que la hipersensibilidad al adhesivo del pañal era el principal factor etiológico de esta nueva identidad.Sus conocimientos por parte de pediatras y dermatólogos evitará errores diagnósticos y llevará a un adecuado enfoque terapeútico
Subject(s)
Infant , Diaper Rash/diagnosis , Diaper Rash/etiology , Diaper Rash/therapy , Dermatology , PediatricsABSTRACT
Presentamos dos pacientes con una nueva forma clínica de dermatitis en la zon del pañal,El dato clínico mas revelante ha sido su particular localización en la cara lateral de cadera y glúteo,así como su morfología triangular invertida.En ambos pacientes se realizó la prueba del parche y se estableció que la hipersensibilidad al adhesivo del pañal era el principal factor etiológico de esta nueva identidad.Sus conocimientos por parte de pediatras y dermatólogos evitará errores diagnósticos y llevará a un adecuado enfoque terapeútico
Subject(s)
Infant , Diaper Rash/etiology , Diaper Rash/therapy , Diaper Rash/diagnosis , Dermatology , PediatricsABSTRACT
El síndrome de Apert o acrocefalosindactilia tipo I, es un trastorno congénito de herencia autosómica dominante, aunque se han descripto casos de mutación espontánea. Se caracteriza por malformaciones craneofaciales, y sindactilia de manos y pies. En menor proporción hay alteraciones cutáneas, cardiovasculares, genitourinarias, gastrointestinales y respiratorias. Comunicamos el caso de un paciente de 34 años con manifestaciones clínicas de este síndrome y resaltamos el compromiso cutáneo. Revisamos la bibliografía existente al respecto (AU)
Subject(s)
Humans , Male , Adult , Acrocephalosyndactylia/diagnosis , Acrocephalosyndactylia/genetics , Acrocephalosyndactylia/epidemiology , Syndactyly/etiology , Intellectual Disability/etiology , Skin Diseases/etiology , Heart Defects, Congenital/etiology , Alopecia/etiology , Acne Vulgaris/etiologySubject(s)
Hamartoma/pathology , Lipomatosis/pathology , Skin Diseases/pathology , Adipose Tissue/pathology , Biopsy, Needle , Buttocks , Child , Female , Humans , Immunohistochemistry , PrognosisABSTRACT
Juvenile hyaline fibromatosis (JHF) is a rare autosomal recessive disease with onset in infancy or early childhood. It is characterized by papulonodular skin lesions, soft tissue masses, gingival hypertrophy, and flexion contractures of the large joints. The light and electron microscopic features are very distinctive. Here we report an 8-month-old boy with characteristic stiffness of the knees and elbows and pink confluent papules on the paranasal folds, and periauricular and perianal regions. He also had hard nodules all over the scalp and around the mouth, and severe gingival hypertrophy. Histologic and ultrastructural features were typical of JHF. Clinical features, pathology, and physiology are discussed.
