Ectopic prostatic tissue in the uterine cervix.

This is the first reported case of ectopic prostatic tissue in the uterine cervix, diagnosed in a 38-year-old woman. A cluster of benign prostatic glands with cribriform and papillary patterns and focal squamous metaplasia occupied the superficial endocervical stroma. The glands were immunoreactive for prostatic specific antigen and prostatic specific acid phosphatase. This lesion, which could be confused with microglandular hyperplasia, mesonephric rests, or adenocarcinoma in situ may represent an embryonic rest.

[Whipple's disease. A case report and review of the literature]. / Enfermedad de Whipple. Informe de un caso y revisión de la literatura.

A 19 year-old man had a clinical history of volvulus, ascites and abdominal pain; later, malabsorption syndrome was recognized. Jejunal biopsies obtained by endoscopic technique show changes consistent in Whipple's disease with minimal intestinal involvement and atrophy. This case report is the first in which volvulus, minimal intestinal involvement and malabsorption syndrome were recognized together. Treatment was successful with trimethoprim-sulfamethoxazole. A literature review with emphasis in recent topics, was made.

Oat cell carcinoma of the gallbladder.

Among 448 malignant epithelial tumors of the gallbladder, 19 were classified as oat cell carcinomas. Seventeen cases occurred in elderly women. Eighteen of the patients had cholelithiasis. The neoplasms were highly lethal, metastasizing early and causing death shortly after diagnosis. All 19 patients died as a direct result of the tumors, with liver, regional lymph node, and/or lung metastases. Combination chemotherapy produced objective responses in two patients, the longest survivors of the series (11 and 13 months). The salient morphologic features of oat cell carcinomas of the gallbladder include large size at the time of diagnosis, extensive necrosis, and propensity for submucosal growth. Histologically, these tumors are composed of variable proportions of two cell types, round and fusiform, arranged in solid sheets, cords, or festoons. In areas of necrosis, the deposition of DNA in vessel walls is seen occasionally. Four tumors contained neoplastic glands similar to those present in well-differentiated adenocarcinomas of the gallbladder. These tumors were considered to be a combined form of oat cell carcinoma. With the use of immunoperoxidase stains, focal carcinoembryonic antigen reactivity was demonstrated in three of 11 tumors. Electron microscopic examination revealed neurosecretory granules. Morphologically, these tumors resembled the oat cell carcinomas that occur at other sites.

The ultrastructure of gallbladder carcinoma.

Nine malignant epithelial tumors of the gallbladder were examined electron microscopically. The tumors included the following subtypes: well-differentiated adenocarcinoma, signet ring cell carcinoma, adenosquamous carcinoma, and oat cell carcinoma. Well-differentiated adenocarcinomas recapitulated the ultrastructure of the normal surface epithelium of the gallbladder. Although columnar cells predominated, the narrow and dark-staining pencil-like cells were also present. The former appeared immature and secreted more mucin than normal columnar cells. Microvilli with long dense core rootlets were seen in one tumor. The most characteristic ultrastructural features of the signet ring cell carcinoma were the multiple mucin vacuoles and the intracytoplasmic lumina some of which appeared cystically dilated. Adenosquamous carcinomas were composed of four different cell types. Well-differentiated adenocarcinomas and adenosquamous carcinomas showed in addition a few endocrine cells similar to these seen in the human gallbladder mucosa in association with intestinal metaplasia. Oat cell carcinomas contained neurosecretory granules but also exhibited glandular markers. Electron microscopy seems the most reliable method for the identification of oat cell carcinomas.

Multiple endocrine neoplasia. Pituitary adenoma, multicentric papillary thyroid carcinoma, bilateral carotid body paraganglioma, parathyroid hyperplasia, gastric leiomyoma, and systemic amyloidosis.

Multiple endocrine neoplasia in a 70-year-old woman are described. The findings include a nonfunctioning pituitary adenoma, a multicentric papillary thyroid carcinoma, bilateral carotid body paragangliomas, parathyroid hyperplasia, gastric leiomyoma and systemic amyloidosis. A study of the kindred revealed that two family members, a daughter and a granddaughter, have clinical and radiographic evidence of pituitary tumors and bilateral carotid body paragangliomas, suggesting that this may represent a genetically determined syndrome inherited as an autosomal dominant.