1.
ACS Chem Biol
; 12(10): 2535-2537, 2017 10 20.
Article
in English
| MEDLINE
| ID: mdl-28886246
ABSTRACT
Anions have long been known to engage in stabilizing interactions with electron-deficient arenes. However, the precise nature and energetic contribution of anion-π interactions to protein stability remains a subject of debate. Here, we show that placing a negatively charged Asp in close proximity to electron-rich Phe in a reverse turn within the WW domain results in a favorable interaction that increases WW conformational stability by -1.3 kcal/mol.