ABSTRACT
The authors report a Kuwaiti Arab family in which the father and one of his two sons have severe hypolacrimation with blotchy staining of the cornea and punctate staining of the interpalpebral bulbar conjunctiva by fluorescein and Rose Bengal. Pharmacologic testing together with biochemical analysis and systemic examinations and investigations suggest an isolated dysfunction of lacrimation. The authors' small Arab family differs from the only other recorded pedigree (Irish) in which all five affected members in four generations also had atopy.
Subject(s)
Lacrimal Apparatus Diseases/congenital , Tears/metabolism , Adult , Child, Preschool , Family , Fluorescein , Fluoresceins , Humans , Lacrimal Apparatus/abnormalities , Lacrimal Apparatus Diseases/genetics , Male , Osmolar Concentration , Pedigree , Rose Bengal , Tears/chemistryABSTRACT
The clinical picture and laboratory findings of a case of secondary herpes simplex virus type 2 in a patient with congenital dysgammaglobulinemia who was followed for 26 months is described. Local combined therapy of acyclovir and Decadron (dexamethasone) 0.1% was given for management for 14 months. The clinical and immunopathologic findings of our patient match the results described by other investigators in experimental animals.
