1.
Org Lett
; 12(22): 5306-9, 2010 Nov 19.
Article
in English
| MEDLINE
| ID: mdl-21033723
ABSTRACT
The synthesis of Lys(3) tamandarin M is described. This analogue can be used as a protein affinity ligand to probe the mechanism of action of this unique class of molecules.
Subject(s)
Depsipeptides/chemical synthesis , Catalysis , Depsipeptides/chemistry , Molecular Structure , Trimethylsilyl Compounds/chemical synthesis , Trimethylsilyl Compounds/chemistry
2.
Tetrahedron Lett
; 51(13): 1635-1638, 2010 Mar 31.
Article
in English
| MEDLINE
| ID: mdl-20190874
ABSTRACT
A reliable, high yielding cyclization protocol for the macrocycle of tamandarin B is presented. This strategy will facilitate the synthesis of side chain analogues.
3.
J Org Chem
; 75(9): 3027-36, 2010 May 07.
Article
in English
| MEDLINE
| ID: mdl-20345143
ABSTRACT
The syntheses of three tamandarin B analogues are described. The goal of these studies was to prepare material to determine their relative therapeutic index and to gain an oversight as to their potential for clinical applications.
