ABSTRACT
In this paper we carried out an immunohistochemical study of cyclin D1 (DCS6 ) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at "Virgen de la Salud" Hospital (Toledo, Spain) for a time of 5 years. In the cases with lymph node metastasis we also studied cyclin D1 expression at this level. Furthermore we have analysed the value of cyclin D1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between cyclin D1 expression and other clinic and pathologic parameters.
Subject(s)
Carcinoma, Squamous Cell/metabolism , Cyclin D1/biosynthesis , Laryngeal Neoplasms/metabolism , Aged , Humans , Immunohistochemistry , PrognosisABSTRACT
This article report four cases of schwannomas originating in the cervical peripheral nervous branches, which were operated by ENT Department between 1991 and 2004. The difficulty on differential diagnosis and possible complications after the surgery are commented. Speaking of these cases, reference is done about the manage of post surgical neuropathy, very common after interventions on neural or perineural tumour of orocervicofacial area.
Subject(s)
Head and Neck Neoplasms/pathology , Head and Neck Neoplasms/surgery , Neurilemmoma/pathology , Neurilemmoma/surgery , Pain/etiology , Postoperative Complications , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle AgedABSTRACT
En este trabajo hemos estudiado la expresión inmunohistoquímica de la proteína ciclina D1 (DCS6) en una serie de 195 pacientes con cáncer de laringe que fueron diagnosticados, tratados y seguidos durante 5 años en el servicio ORL del Hospital «Virgen de la Salud» (Toledo). En los casos que presentaron metástasis ganglionares analizamos también la expresión de ciclina DI a dicho nivel. Además se estudia el valor pronóstico de la expresión de ciclina D1 en este tipo de tumores (desarrollo de recidivas, mortalidad por cáncer de laringe y supervivencia) y se analiza la posible relación de dicha expresión con otros parámetros clínico-patológicos
In this paper we carried out an immunohistochemical study of cyclin D1 (DCS6) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at fue Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain) for a time of 5 years. In the cases with lymph nade metastasis we also studied cyclin D1 expression at this level. Furthermore we have analysed fue value of cyclin D1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between cyclin D1 expression and other clinic and pathologic parameters
Subject(s)
Humans , Carcinoma, Squamous Cell/pathology , Cyclin D1/analysis , Laryngeal Neoplasms/pathology , Immunohistochemistry/methodsABSTRACT
Se presentan cuatro casos de schwannoma dependientes de las ramas nerviosas periféricas cervicales, intervenidos entre 1991 y 2004 por el Servicio de Otorrinolaringología, su dificultad en el diagnóstico diferencial y las posibles complicaciones de su tratamiento quirúrgico. A propósito del mismo, se hace referencia al manejo de las neuropatías posquirúrgicas, habituales tras la cirugía de tumoraciones neurales o perineurales en el área orocervicofacial
This article report four cases of schwannomas originating in the cervical peripheral nervous branches, which were operated by ENT Department between 1991 and 2004. The difficulty on differential diagnosis and possible complications after the surgery are commented. Speaking of these cases, reference is done about the manage of post surgical neuropathy, very common after interventions on neural or perineural tumour of orocervicofacial area
Subject(s)
Female , Middle Aged , Humans , Neurilemmoma/diagnosis , Neurilemmoma/surgery , Radiography, Thoracic/methods , Neurofibromatoses/complications , Neurofibromatoses , Hyperalgesia/complications , Postoperative Complications/diagnosis , Postoperative Complications/therapy , Pain/etiology , Pain, Postoperative/complications , Neurilemmoma/complications , Pain/therapy , Pain, Postoperative/diagnosis , Neurilemmoma/physiopathology , Neurilemmoma , Diagnosis, Differential , Anticonvulsants/therapeutic useABSTRACT
In this paper we carried out an immunohistochemical study of protein p27KIP1 expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at "Virgen de la Salud" Hospital (Toledo, Spain). In the cases with lymph node metastasis we also studied p27KIP1 expression at this level. Furthermore we have analysed the value of protein p27KIP1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between p27KIP1 expression and other clinic and pathologic parameters.
Subject(s)
Carcinoma, Squamous Cell/metabolism , Cyclin-Dependent Kinase Inhibitor p27/metabolism , Laryngeal Neoplasms/metabolism , Aged , Carcinoma, Squamous Cell/pathology , Humans , Immunohistochemistry , Laryngeal Neoplasms/pathology , Neoplasm Staging , Phenotype , PrognosisABSTRACT
En este trabajo hemos estudiado la expresión inmunohistoquímica del alproteína p27KIp1 en una serie de 195 pacientes con cáncer de laringe que fueron diagnosticados, tratados y seguidos durante al menos 5 años en el servicio ORL del Hospita "Virgen de la Salud" (Toledo). En los casos que presentaron metástasis ganglionares analizamos también la expresión de p27KIP1 a dicho nivel. Además se ha analizado el valor pronóstico de la expresión de p27KIP1 en este tipo de tumores (desarrollo de recidivas, mortalidad por cáncer de laringe y supervivencia) y estudiamos la posible relación de dicha expresión con otros parámetros clinicopatológicos
In this paper we carried out an immunohistochemical study of protein p27KIPI expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain). In the cases with lymph node metastasis we also studied p27KIPI expression at this level. Furthermore we have analysed the value of protein p27KIPI expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between p 27KIPI expression and other clinic and pathologic parameters
Subject(s)
Aged , Humans , Carcinoma, Squamous Cell/metabolism , Laryngeal Neoplasms/metabolism , Carcinoma, Squamous Cell/pathology , Immunohistochemistry , Phenotype , Prognosis , Neoplasm Staging , Laryngeal Neoplasms/pathologyABSTRACT
La amiloidosis es una extraña enfermedad producida por el depósito extracelular de un material proteínico, homogéneo, eosinofílico en forma de fibrillas llamado amiloide. Esto va a producir una alteración de la homeostasia del órgano afectado. Se presentan tres únicos casos diagnosticados en nuestra institución, de amiloidosis laríngea localizada en el periodo comprendido entre el año 1990-2004. El diagnóstico y el tratamiento fue realizado mediante microcirugía endolaríngea convencional. Por otro lado, se expone una revisión bibliográfica actualizada donde se expone las tendencias más actuales sobre este proceso
The amyloidosis is a uncommon and rare entity. It is a condition characterized by the extracellular deposition of homogeneous, eosinophilic proteinaceous material in the form of fibrils called «amyloid». This situation make a disfunction of the homeostasy in the affected place. In this letter we present three cases of localized laryngeal amyloidosis diagnosed between 1990 and 2004. Diagnosis and treatment were made in the three cases by direct laringoscopic and conventional microsurgery. Also we expose a actualised bibliographic review about studies more recent
Subject(s)
Female , Aged , Humans , Amyloidosis/physiopathology , Laryngeal Diseases/physiopathology , Amyloidosis/surgery , Laryngeal Diseases/surgery , HomeostasisABSTRACT
The amyloidosis is a uncommon and rare entity. It is a condition characterized by the extracellular deposition of homogeneous, eosinophilic proteinaceous material in the form of fibrils called "amyloid". This situation make a disfunction of the homeostasy in the affected place. In this letter we present three cases of localized laryngeal amyloidosis diagnosed between 1990 and 2004. Diagnosis and treatment were made in the three cases by direct laringoscopic and conventional microsurgery. Also we expose a actualised bibliographic review about studies more recent.
Subject(s)
Amyloidosis/pathology , Laryngeal Diseases/pathology , Adult , Aged , Amyloidosis/surgery , Female , Humans , Laryngeal Diseases/surgery , MaleABSTRACT
Clinical findings, histopathology, therapeutic management and evolution of 8 cases of laryngeal verrucous carcinomata, treated at Virgen de la Salud Hospital from 1981 till 1997, are discussed. With the excuse of perform a retrospective perusal of our series, the AA. review the medical literature regarding possible new questions about this uncommon growth: as radiotherapy versus surgery and aetiological link of the tumor with the human papilloma virus.
Subject(s)
Carcinoma, Verrucous/pathology , Laryngeal Neoplasms/pathology , Aged , Carcinoma, Verrucous/etiology , Carcinoma, Verrucous/therapy , Humans , Laryngeal Neoplasms/etiology , Laryngeal Neoplasms/therapy , Male , Middle Aged , Retrospective StudiesABSTRACT
The AA. report the case of a 68-year-old man, treated in their ENT-Department, presenting with amyloid accumulations in the larynx in the context of systemic amyloidosis associated to a multiple myeloma. Review of diagnostic methods in order to identify the lesion and the general malady as well. Approach to the adequate treatment.
Subject(s)
Amyloidosis/etiology , Amyloidosis/physiopathology , Brain Neoplasms/complications , Brain Neoplasms/pathology , Larynx/physiopathology , Medulla Oblongata/pathology , Multiple Myeloma/complications , Multiple Myeloma/pathology , Aged , Amyloidosis/diagnosis , Brain Neoplasms/diagnosis , Diagnosis, Differential , Humans , Male , Multiple Myeloma/diagnosisABSTRACT
Primitive involvement of the palatine tonsil with a nodular paragranuloma (nodular subtype of Hodgkin's malady with lymphocytic predominance) is rarely found, being larger in number the cases associated with simultaneous occurrence in other organs. In the paper the AA. report one of this instances sitting solitarily in the palatine amygdala (stadium IA). Furthermore a bibliographic review about Waldeyer's ring lymphoma and particularly on nodular Hodgkin's paragranuloma is displayed.
Subject(s)
Hodgkin Disease/pathology , Palatine Tonsil/pathology , Tonsillar Neoplasms/pathology , Humans , Male , Middle AgedABSTRACT
The aim of this report is to compare the use of tympanostomy tubes (in 190 ears) versus the realization of myringotomy without any posterior placement of tubes (in 19 ears) in the treatment of 108 children with secretory otitis media. Course, sequelae and complications were analyzed over a period of 2 to 9 years. Our results suggest that the use of tympanostomy tubes must follow some specific indications, since they are not free of complications and sequelae.
