ABSTRACT
During this experimental work, we studied the immunological recuperation in CD1 mice in whom a weakening disease was induced using intraperitoneal injections of a sterile mixture of dead staphylococci. After a deep depression of the synthesis of anti-sheep red blood cell antibodies (SRBC) during the following 10 days after the induction of wasting, the animals regained their capability to produce anti-SRBC antibodies, significantly increasing. Two weeks after the injections were applied, the average number of antibody producing cells rose significantly and even doubled in the control group of healthy mice. Finally, after two weeks after this "rebound", the number of antibody forming cells return to normality. The article includes a discussion on the biological significance of this carried out in experimental animals while offering a hope for children with secondary immunological deficiencies or for those with repeatedly severe infections.
Subject(s)
Immunologic Deficiency Syndromes/immunology , Animals , Animals, Newborn , Antibody Formation , MiceABSTRACT
The immunological competence of a newborn mice group, inoculated with a heat killed suspension of staphylococci, was studied to find out if the treated mice preserved the immunological competence of the T lymphocytes, for induce an allograft. A group of CD1 newborn male mice were injected intraperitoneally with the bacterial suspension, every three days during a four weeks period. Other group received only isotonic saline solution. The lymphocyte ability to form hemolytic plaques and their capacity to provoke a local graft-versus-host reaction in F1 receptor animals was studied in both groups. The results showed that the staphylococci treated newborn mice had a decreased capacity to form anti-erythrocyte antibodies without modification in their reactivity against histoincompatible antigens. Newborn mice, runting-like disease; bacterial inoculation; immunological response in.