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1.
Med Clin North Am ; 100(1): 103-15, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26614722

ABSTRACT

Invasive analgesic therapies provide an alternative to medical management of chronic pain. With the increasing incidence of chronic pain not only in the United States but worldwide, more therapies have evolved to address the growing need for pain relief options. These therapies include spinal injections, nerve blocks, radiofrequency ablation, neurostimulation, and intrathecal drug delivery.


Subject(s)
Chronic Pain/therapy , Pain Management/methods , Electric Stimulation Therapy/methods , Evidence-Based Medicine , Humans , Injections, Epidural/methods , Nerve Block/methods , Treatment Outcome , United States
2.
Eur J Pharmacol ; 722: 67-78, 2014 Jan 05.
Article in English | MEDLINE | ID: mdl-24157979

ABSTRACT

Opioids are broad spectrum analgesics that are an integral part of the therapeutic armamentarium to combat pain in the palliative care population. Unfortunately, among the adverse effects of opioids that may be experienced along with analgesia is nausea, vomiting, and/or retching. Although it is conceivable that in the future, using combination agents (opioids combined with agents which may nullify emetic effects), currently nausea/vomiting remains a significant issue for certain patients. However, there exists potential current strategies that may be useful in efforts to diminish the frequency and/or intensity of opioid-induced nausea/vomiting (OINV).


Subject(s)
Analgesics, Opioid/adverse effects , Nausea/chemically induced , Vomiting/chemically induced , Animals , Antiemetics/pharmacology , Antiemetics/therapeutic use , Humans , Nausea/drug therapy , Nausea/metabolism , Nausea/physiopathology , Neurotransmitter Agents/metabolism , Pharmacogenetics , Vomiting/drug therapy , Vomiting/metabolism , Vomiting/physiopathology
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