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Bioorg Med Chem Lett
; 11(19): 2585-8, 2001 Oct 08.
Article
in English
| MEDLINE
| ID: mdl-11551755
ABSTRACT
By screening a library of metalloenzyme inhibitors, the N-formyl-hydroxylamine derivative BB-3497 was identified as a potent inhibitor of Escherichia coli peptide deformylase with antibacterial activity both in vitro and in vivo. The homochiral synthesis of BB-3497, involving a novel asymmetric Michael addition reaction is described.