ABSTRACT
BACKGROUND: In three previous reports of primary hypertrophic osteoarthropathy, an associated extramedullary hematopoiesis was related to myelofibrosis. CASE REPORT: A 44-year-old male patient with primary hypertrophic osteoarthropathy diagnosed when he was 34-year-old was referred to our hospital with an abdominal mass fortuitously detected. DISCUSSION: The present case is unique for the patient developed an extramedullary hematopoïesis without associated myelofibrosis. It suggests the possible intervention of growth factors common to the skin fibroblasts and the blood progenitor cells in the pathogenesis of primary osteoarthropathy.
Subject(s)
Abdomen , Hematopoiesis, Extramedullary , Osteoarthropathy, Primary Hypertrophic/complications , Primary Myelofibrosis/etiology , Adult , Humans , Male , Osteoarthropathy, Primary Hypertrophic/diagnosis , Osteoarthropathy, Primary Hypertrophic/surgery , Tomography, X-Ray ComputedABSTRACT
We describe a patient with systemic onset juvenile chronic arthritis who developed clinical and electromyographic features of acquired Isaacs' syndrome. This association has not been reported before and possible links between the 2 diseases are discussed.
Subject(s)
Arthritis, Juvenile/complications , Fasciculation/etiology , Child , Electromyography , Fasciculation/diagnosis , Female , HumansABSTRACT
We report three cases of iatrogenically induced vertebral osteomyelitis due to Pseudomonas aeruginosa. One case was a post-nucleotomy and post-operative complication of herniated disk treatment, one was related to infection of an epidural catheter in a patient suffering from rheumatoid arthritis and the third followed urinary investigation in a patient with prostate cancer. Infection was cured in all patients with antibiotic treatment. These case reports shed light on the possibility of infections with pseudomonas aeruginosa, in addition to the more common infections such as by staphylococci, especially following iatrogenic maneuvers.
Subject(s)
Iatrogenic Disease , Osteomyelitis/microbiology , Pseudomonas Infections , Spinal Diseases/microbiology , Adenoma/surgery , Adult , Aged , Anesthesia, Epidural/adverse effects , Catheterization/adverse effects , Female , Humans , Intervertebral Disc Displacement/surgery , Male , Middle Aged , Osteomyelitis/diagnostic imaging , Postoperative Complications , Prostatic Neoplasms/surgery , Spinal Diseases/diagnostic imaging , Tomography, X-Ray Computed , Urinary Catheterization/adverse effectsABSTRACT
Pyoderma gangrenosum is well known as an associated feature of inflammatory bowel disease (IBD). Recently, higher than normal prevalence of IBD in patients with the SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome has been reported. However, the association of pyoderma gangrenosum with SAPHO syndrome without definitely excluded IBD has not been reported. We describe a case that suggests a possible connection between these 2 entities.
Subject(s)
Acne Vulgaris/complications , Hyperostosis/complications , Osteitis/complications , Psoriasis/complications , Pyoderma Gangrenosum/complications , Synovitis/complications , Adult , Humans , Hyperostosis/diagnostic imaging , Male , Osteitis/diagnostic imaging , Pyoderma Gangrenosum/pathology , Radiography , Radionuclide Imaging , SyndromeABSTRACT
In order to establish a working cellular model for the study of post-receptor signaling events, insulin-dependent phosphatidylinositol 3' (PtdIns 3')-kinase activity was investigated in circulating mononuclear cells from normal subjects. The p85 alpha regulatory subunit of PtdIns 3'-kinase co-precipitated with activated insulin receptor as revealed by immunoblotting. Whereas insulin receptor substrate-1 was weakly detected, insulin increased 5.5 +/- 1.5-fold (mean +/- SD) PtdIns 3'-kinase activity in receptor immunoprecipitates. We conclude that insulin-stimulated PtdIns 3'-kinase activity is measurable in circulating mononuclear cells which may constitute an easily available cellular model for the detection of post-receptor defects in insulin-resistant states.
