ABSTRACT
BACKGROUND: To the best of our knowledge, only 52 cases of squamous cell carcinoma (SCC) complicating hidradenitis suppurativa (HS) have been reported since 1958. We describe 13 new cases. METHODS: We propose a clinical and histological analysis of our cases. We include these results in a review of previously reported cases to analyze a total of 65 patients. In our series of 13 cases, we also investigate the presence of human papillomavirus (HPV) in tumor samples, by polymerase chain reaction (PCR) on paraffin-embedded material. RESULTS: Malignant transformation affects mainly men with a long-term history of genitoanal HS. Although our cases were 7 well-differentiated carcinomas and 6 verrucous carcinomas, lymphatic and visceral metastasis occurred in 2 and 3 cases, respectively. With PCR, we demonstrated presence of HPV in genitoanal tumoral lesions, principally HPV-16. CONCLUSION: SCC complicating HS evolves poorly, despite a good histological prognosis. Our results sustain the implication of HPV in the malignant transformation of HS.
Subject(s)
Anus Neoplasms/pathology , Carcinoma, Squamous Cell/pathology , Hidradenitis Suppurativa/pathology , Human papillomavirus 16 , Papillomavirus Infections/pathology , Urogenital Neoplasms/pathology , Adolescent , Adult , Anus Neoplasms/complications , Anus Neoplasms/virology , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/virology , Carcinoma, Verrucous/complications , Carcinoma, Verrucous/pathology , Carcinoma, Verrucous/virology , Cell Transformation, Neoplastic/pathology , Female , Hidradenitis Suppurativa/complications , Hidradenitis Suppurativa/virology , Humans , Male , Papillomavirus Infections/complications , Retrospective Studies , Smoking/adverse effects , Urogenital Neoplasms/complications , Urogenital Neoplasms/virology , Young AdultABSTRACT
INTRODUCTION: Takayasu arteritis (TA) is an inflammatory arteritis affecting large vessels, predominantly the aorta, its main branches, and the pulmonary arteries. Up to now, arteriography was considered as the "gold standard". But others exams are emerging in the management of TA: vascular ultrasound, angio-scanner, magnetic resonance imaging and 18FDG positron emission tomography (18FDG PET). Such investigations allow a study of the lumen but also of the arterial walls. However, at the time, no biological or radiological test is able to determine the activity of TA. 18FDG PET could be effective to estimate the disease activity. EXEGESIS: We report the case of a young woman for who 18FDG PET permit to assert a relapse of TA. CONCLUSION: 18FDG PET could be effective to estimate the disease activity.
