[The EEG correlates of delayed mental development in adolescents].

Fifty-eight male adolescents aged 15-17 years have been divided into 3 groups: 31 patients with mental infantilism syndrome were included in the study group, 14 with organic brain disorders--in the comparison group and 13 psychiatrically and neurologically normal subjects--in the control group. EEG was recorded from 12 leads monopolarly at rest, during hemisphere-specific cognitive tasks performance and exposure to aversive sound stimulation. Two-Hz wide EEG spectral ranges--A, theta1, theta2, alpha1 and alpha2--were analyzed. Only in the study group, there were decreased values of alpha2 spectral power (SP) and reduced reactivity to functional tests and insufficient lateral differentiation of the reactions during the cognitive tasks performance. Maximal deviation of the SP reactivity indices as compared to the comparison group was found in alpha2 range. The disturbances obtained indicate the delay of brain maturation and retardation in formation of specific neural networks. The results of the study demonstrate that indices of alpha2 SP may be considered as objective criteria of delayed mental maturation.

[Psychogenic neurotic depression in women (psychopathological and psychosomatic aspects)]. / Psikhogennye nevroticheskie depressii u zhenshchin (psikhopatologicheskie i psikhosomaticheskii aspekty).

Examination of 85 female inpatients with psychogenic neurotic mood disorders aged from 18 to 48 years has found the following depression syndrome variants: asthenic (42 patients), anxiety (14), asthenoanxiety (15), anxiety-melancholic (14). Hypothymia both mildly or moderately expressed and psychosomatic disorders as functional disturbances of reproductive, nervous and cardiovascular systems, were found. These disturbances were qualified as somatoform disorders. The most typical was autonomic dystonia syndrome. During the course of depression, somatization of psychic disorders was increasing, being most distinct in asthenic variants.

[The humoral immunity characteristics of women with neurotic depressions]. / Osobennosti gumoral'nogo immuniteta u zhenshchin s nevroticheskimi depressiiami.

The levels of autoantibodies and their anti-idiotypes to proteins of nervous tissue (S100b, GFAP, MP65 and nerve growth factor) were studied in 85 women of 18-48 years of age with psychogenic neurotic depressions. It was found that the changes of the levels of autoantibodies to the proteins of nervous tissue correspond to various somatoautonomic manifestations and correlate with severity of depression, its typological variations and duration of the disease. The data obtained show a close relationship between nervous and immune systems that was expressed by some parallelism of the dynamics of the changes of both neurotic depressive symptoms and serum immunoreactivity to neuroantigens.

[Autoantibodies against nerve tissue proteins long after cranio-cerebral injury]. / Autoantitela k belkam nervnoi tkani v otdalennom periode cherepno-mozgovoi travmy.

20 samples of serum of patients with remote consequences of brain trauma were tested to detect autoantibodies (a-AB) against brain proteins S-100 and NKP. Essential pathology was not found out by standard solid-phase immunoassay. The original method was used to detect a-AB to the whole complex of antigen determinants. Using this method the elevation of a-AB against S-100 and NKP was shown at 16 cases. The disturbance of idiotype-antiidiotype regulation was revealed at this group of patients. It is suggested that insufficient level of corresponding antiidiotypes creates the conditions for autoimmune aggressor of a-AB against brain tissue.