A systematic review on the effect of work-related stressors on mental health of young workers.

PURPOSE: There is no review on the effect of work-related stressors on mental health of young workers. We systematically reviewed epidemiological evidence on this relationship. METHODS: The review searched eight databases: Embase, PubMed, Web of Science, Cinahl, Cochrane Library, Informit, PsycINFO, and Scopus from their respective start dates until May 2017. Studies that have examined a mental health outcome in relation to a work-related stressor as exposure in young workers were included. The review was reported based on the PRISMA statement. RESULTS: Three cross-sectional studies and six longitudinal cohort studies were included. Cross-sectional evidence showed that adverse work conditions including working overtime, job boredom, low skill variety, low autonomy, high job insecurity, and lack of reward were associated with poor mental health of young workers. Longitudinal evidence showed that high job demands, low job control, effort-reward imbalance, and low work support (men only) were associated with poor mental health. There was evidence on the contemporaneous relationship between two or more adverse work conditions and poor mental health. CONCLUSIONS: Although more research (particularly high-quality longitudinal studies) is warranted in this area, our review indicates that work-related stressors have a negative impact on the mental health of young workers. The current review suggests that workplace interventions and policy are required to improve the quality of work for young workers.

The relationship between an electronic mental health stigma campaign and suicidal thoughts and behaviours: a two-arm randomized controlled trial in the Australian construction industry.

Males employed in the construction industry are at greater risk of suicide than other employed males. It is plausible that a high level of stigma against mental health problems explains the elevated rates of suicide among this group. This study sought to test the effectiveness of an electronic mental health stigma intervention on suicide ideation, communication about suicide and attempts. Participants were randomly assigned to receive either a series of brief contact interventions over a 6-week period or a wait list control. Suicidal ideation, communication about suicide and suicide attempts were assessed using the Suicidal Behaviors Questionnaire-Revised at post-intervention. We used linear regression to assess effectiveness at post-intervention, adjusting for relevant covariates using both conventional methods and a propensity score approach. Results indicate that the intervention had no significant impact on suicidal thoughts, communication or suicide attempts. There was some indication that individuals in the intervention group reported a slight increase in attempts and communication about suicide. These observations underscore an urgent need for more research to understand the complex and nuanced relationship between stigma and suicide in non-clinical populations.

The impact of sexual orientation on body image, self-esteem, urinary and sexual functions in the experience of prostate cancer.

Prostate cancer (PCa) poses a large health burden globally. Research indicates that men experience a range of psychological challenges associated with PCa including changes to identity, self-esteem and body image. The ways in which sexual orientation plays a role in the experience of PCa, and the subsequent impact on quality of life (QoL), body image and self-esteem have only recently been addressed. By addressing treatment modality, where participant numbers were sufficient, we also sought to explore whether gay (homosexual) men diagnosed with PCa (PCaDx) and with a primary treatment modality of surgery would report differences in body image and self-esteem compared with straight (heterosexual) men with PCaDx with a primary treatment modality of surgery, compared with gay and straight men without PCaDx. The results of our study identified overall differences with respect to PCaDx (related to urinary function, sexual function and health evaluation), and sexual orientation (related to self-esteem), rather than interactions between sexual orientation and PCaDx. Gay men with PCaDx exhibited higher levels of urinary functioning than straight men with PCaDx, the difference being reversed for gay and straight men without PCaDx; but this result narrowly failed to achieve statistical significance, suggesting a need for further research, with larger samples.

A smart-phone intervention to address mental health stigma in the construction industry: A two-arm randomised controlled trial.

BACKGROUND: High levels of self-stigma are associated with a range of adverse mental health, treatment, and functional outcomes. This prospective study examined the effects of an electronic mental health stigma reduction intervention on self-stigma (self-blame, shame, and help-seeking inhibition) among male construction workers in Australia. METHOD: Male construction workers (N = 682) were randomly assigned to receive either the intervention condition or the wait list control over a six-week period. Self-stigma was assessed using the Self-Stigma of Depression Scale at post-intervention. We conducted linear regression to assess the effectiveness of the intervention on self-stigma, adjusting for relevant covariates. RESULTS: Self-stigma was relatively low in the sample. The intervention had no significant effect on self-stigma, after adjusting for confounders. There were reductions in stigma in both the intervention and control groups at 6-week follow-up. Process evaluation indicated that participants generally enjoyed the program and felt that it was beneficial to their mental health. CONCLUSIONS: These observations underscore the need for further research to elucidate understanding of the experience of self-stigma among employed males.

Combined therapeutic effects of vinblastine and Astragalus saponins in human colon cancer cells and tumor xenograft via inhibition of tumor growth and proangiogenic factors.

Our previous study had demonstrated that Astragalus saponins (AST) could reduce the side effects of orthodox chemotherapeutic drugs, while concurrently promote antitumor activity. In the present study, we attempted to investigate the potential synergistic anticarcinogenic effects of AST and a vinca alkaloid vinblastine (VBL). Reduced expression of key proangiogenic and metastatic factors including VEGF, bFGF, metalloproteinase (MMP)-2, and MMP-9 was detected in VBL-treated colon cancer cells, with further downregulation by combined VBL/AST treatment. Subsequently, VBL or AST decreased LoVo cell invasiveness, with further reduction when the drugs were cotreated. Significant growth inhibition and cell cycle arrest at G2/M phase were achieved by either drug treatment with apparent synergistic effects. VBL-induced apoptosis was confirmed but found to be unrelated to induction of the novel apoptotic protein NSAID-activated gene 1. In vivo study in tumor xenograft indicates that combined VBL/AST treatment resulted in sustained regression of tumor growth, with attenuation of the neutropenic and anemic effects of VBL. In addition, downregulation of proangiogenic and proliferative factors was also visualized, with boosting effect by combined drug treatment. These findings have provided evidence that AST combined with adjuvant chemotherapeutics like VBL could alleviate cancer development through diversified modes of action, including the regulation of angiogenesis.

Astragalus saponins modulate cell invasiveness and angiogenesis in human gastric adenocarcinoma cells.

AIM OF THE STUDY: We had reported that Astragalus saponins (AST) exert promising anti-tumorigenic effects by suppressing the growth of HT-29 human colon cancer cells and tumor xenograft. In the present study, we further investigated the anti-angiogenic property of AST in human gastric adenocarcinoma cells (AGS) and attempted to elucidate the underlying mechanism. MATERIALS AND METHODS: Viability of AGS cells was measured by using the MTT reduction method. Western blotting was performed to examine the effect of AST on apoptotic- and cell growth-related protein expression. Effect of AST on cell cycle progression was also evaluated using PI staining. A Matrigel invasion assay was then employed to demonstrate the effect of AST on the invasiveness of gastric cancer cells. The expression of invasion-associated proteins (VEGF and MMPs) was also investigated. RESULTS: AST could induce apoptosis in AGS cells by activating caspase 3 with subsequent cleavage of poly(ADP-ribose) polymerase. Besides, cell cycle arrest at the G2/M phase had been observed in AST-treated cells, leading to substantial growth inhibition. The anti-proliferative effect of AST was associated with the regulation of cyclin B1, p21 and c-myc. Results indicate that the number of AGS cells invaded through the Matrigel membrane was significantly reduced upon AST treatment, with concomitant down-regulation of the pro-angiogenic protein vascular endothelial growth factor (VEGF) as well as the metastatic proteins metalloproteinase (MMP)-2 and MMP-9. CONCLUSION: AST derived from the medicinal plant Astragalus membranaceus could modulate the invasiveness and angiogenesis of AGS cells besides its pro-apoptotic and anti-proliferative activities. These findings also suggest that AST has the potential to be further developed into an effective chemotherapeutic agent in treating advanced and metastatic gastric cancers.

Brillouin spectroscopy of YAG-derived optical fibers.

We present Brillouin spectroscopy of YAG-derived optical fibers. It is found that the addition of yttria and alumina both tend to raise the acoustic velocity when added to silica, with the change due to yttria being much weaker. The temperature-dependence of the Stokes's shift in the YAG-derived fibers is also measured, disclosing a lesser temperature dependence than conventional Ge-doped fibers. These fibers are found experimentally to have a substantially larger acoustic attenuation coefficient relative to that of bulk silica, and assuming a photoelastic constant of amorphous YAG similar to that of pure crystalline YAG, a much-reduced Brillouin gain coefficient as a result. A 40 weight percent yttria and alumina fiber has a Brillouin gain coefficient estimated to be roughly one sixth of pure silica. We also show that the addition of Er to the YAG-derived system decreases the acoustic velocity and broadens the Brillouin spectrum.

Experimental investigation of an optically amplified time-division-multiplexed polarization-insensitive fiber-optic michelson interferometric sensor system.

We experimentally investigate optically amplified time-division-multiplexed polarization-insensitive fiber-optic Michelson interferometric (PIFOMI) sensor systems, using an erbium-doped fiber amplifier (EDFA) and a phase-generated carrier (PGC) demodulation technique. The influence of the EDFA on the extinction ratio (ER) of the light pulse and on the minimum phase-detection sensitivity (MPDS) is examined. We find that the EDFA acting as a preamplifier has limited usefulness because the highly amplified spontaneous emission (ASE) noise generated by the EDFA degrades the ER and the MPDS. However, both postamplifiers and in-line EDFA's can work successfully. The MPDS of the unamplified time-division-multiplexed PIFOMI system with an ER of 33 dB was 2.4 x 10(-5) rad/(Hz)(1/2) at ~1 kHz. For maintaining a MPDS of better than 3.4 x 10(-5) rad/(Hz)(1/2) at ~1 kHz, the worst ER's for the postamplified and in-line amplified systems were 20 and 17.8 dB, respectively. The corresponding input signal peak power should be larger than -20 and -25 dBm for the postamplifiers and in-line amplifiers, respectively. When two postamplifiers and two in-line amplifiers are used, an allowable sensor system loss of 47 dB and a link length of the input-output lead fiber of 108 km can be realized for this system with a 32-sensor array. Implementation of optically amplified time-division-multiplexed and wavelength-division multiplexed-time-division multiplexed PIFOMI subarray sensor systems are also addressed.